Clinical trials: GI Disorders
Colorectal Neoplasms
Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases
Correlation and Heterogeneity of the Immune Microenvironment and Histopathological Growth Patterns in Resectable Colorectal Cancer Liver Metastases
- Trial name
- CRLM (NCT07564908)
- Testing
- Formalin-fixed, paraffin-embedded (FFPE) sections of colorectal cancer liver metastases were stained with hematoxylin and eosin (H&E) and Multiplex immunohistochemistry (mIHC) staining.
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Meng Qiu
Colon Cancer Stage III
Lymph Node Ratio and Kras Mutation in R Colon Cancer
clinical impact of LN ratio with Kras expression in colon cancer
- Trial name
- NCT04342676
- Testing
- k ras, Panitumumab
- Where
- Egypt
- Volunteers
- 433 people
- Sponsor
- Mansoura University
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Gastrointestinal Hemorrhage
The Clinical Feature of Ulcer Base Over Time After Prophylactic Argon Plasma Coagulation in Colonic EMR
The prophylactic APC right after colonic EMR doesn't mean the complete coagulation of visible vessel because of injection material.
- Trial name
- NCT02025764
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Metastatic Colorectal Cancer
Lonsurf® (Trifluridine/Tipiracil) Plus Chemotherapy in Metastatic Colorectal Cancer Prospective Study in Taiwan
Primary Endpoint : To evaluate the Disease control rate (DCR) Secondary Endpoints: To evaluate the Progression-free survival (PFS), Overall survival(OS) and Safety profile
- Trial name
- NCT06495463
- Testing
- Trifluridine/tipiracil
- Where
- Taiwan
- Volunteers
- 97 people
- Sponsor
- Chang Gung Memorial Hospital
Eosinophilic Esophagitis, Eosinophilic Gastrointestinal Disorders (EGIDs)
Eosinophilic Esophagitis Intervention Trial-1 Food vs. 4 Food Elimination Diet Followed by Swallowed Glucocorticoids
The purpose of this interventional study is to test and compare the effectiveness of two elimination diets-the 1-food elimination diet (1FED, milk only) and the 4-food elimination diet (4FED, milk, egg, wheat, and soy) for…
- Trial name
- NCT02610816
- Testing
- 1 Food Elimination Diet, 4 Food Elimination Diet, 4 Food Elimination Diet (post 1FED failure)
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colostomy, Colorectal Neoplasm
A Randomized Trial on the Technical Aspects of Stoma Construction.
An investigation on the difference in stoma hernia frequency related to surgical technique when incising the fascia. All patients planned for elective colostomy formation are to be included.
- Conditions
- Colostomy, Colorectal Neoplasm, Diverticulitis
- Trial name
- NCT01694238
- Testing
- Cruciate incision, Circular incision, Mesh enforced cruciate incision
- Where
- Sweden
- Volunteers
- 209 people
- Sponsor
- Sahlgrenska University Hospital
Prematurity, Necrotizing Enterocolitis
Prediction of NEC With Urinary iFABP
During the first four days of life, intestinal fatty acid binding protein (iFABP) is elevated in the urine of premature babies who go on to develop necrotizing enterocolitis (NEC) days to weeks later.
- Trial name
- NCT01805206
- Testing
- Assessment of urinary iFABP, Administration of enteral feedings
- Where
- United States
- Sponsor
- Loma Linda University
Necrotizing Enterocolitis
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of ST266 in Infants With Necrotizing Enterocolitis (NEC)
The primary objective of this study is to determine the safety and tolerability of two dose levels (0.5 mL/kg and 1.0 mL/kg) of once daily (QD) via IV route of administration of ST266 in treating patients with Bell's stage IIA or…
- Trial name
- NEC (NCT06315738)
- Testing
- ST266
- Where
- 8 sites in United States
- Volunteers
- 36 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Inflammatory Bowel Diseases
Tacrolimus Versus Methotrexate as Rescue Therapy for Refractory Inflammatory Bowel Disease
Mesalazine, steroid, immunosuppressants and biologic agents are main medical treatments in treating inflammatory bowel diseases. Yet some patients develop severe side effects or initial invalid to conventional therapies.
- Trial name
- NCT03204136
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, China
Cryptosporidiosis, HIV Infections
A Double-Blind, Placebo-Controlled Trial of Paromomycin for Treatment of Cryptosporidiosis in Patients With Advanced HIV Disease and CD4 Counts Under 150 Cells/mm3
To determine the effectiveness of oral paromomycin sulfate for 21 days compared to placebo in the treatment of cryptosporidiosis in patients with HIV infection. To evaluate the safety of oral paromomycin at two different doses.
- Trial name
- NCT00000771
- Testing
- Paromomycin sulfate
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 68 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gastroesophageal Reflux Disease
Gastric Accommodation and Gastroesophageal Reflux
Gastroesophageal reflux events generally happen during relaxation of lower esophageal sphincter. This relaxation is a reflex that is triggered by gastric stimuli.
- Trial name
- NCT01078064
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nationwide Children's Hospital
Gastrointestinal Stromal Tumor
A Study on Non-invasive Early Diagnosis of Gastrointestinal Stromal Tumors and Differentiation of Benign and Malignant Nodules
Gastrointestinal Stromal Tumors (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, and the incidence rate in China has increased year by year in recent years.Gastrointestinal stromal tumors are not…
- Trial name
- NCT04143048
- Testing
- DNA extraction of tumer tissue samples and high-throughput sequencing of small panels, DNA extraction of tumer tissue samples and blood sample and high-throughput sequencing of small panels
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Cushing's Syndrome, Pituitary Adenoma
Defining the Genetic Basis for the Development of Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and the Carney Complex
Lentiginosis refers to groups of diseases marked by the presence of pigmented spots on the skin. These conditions are most commonly associated with multiple tumors and changes in hormone producing glands.
- Conditions
- Cushing's Syndrome, Pituitary Adenoma, Carney Complex, Primary Pigmented Nodular Adrenocortical Disease
- Trial name
- NCT00001452
- Testing
- oCRH
- Where
- United States
- Volunteers
- 1,387 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Hypnotherapy Through Self-exercises in Children With Functional Abdominal Pain in Primary Care
The goal of this randomised controlled trial is to study the (cost-)effectiveness of home-based hypnotherapy by self-exercises in children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) in primary care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
- Trial name
- ZelfHy (NCT05636358)
- Testing
- Home-based hypnotherapy
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- University Medical Center Groningen
Diarrhoea;Infectious;Presumed, Diarrhea, Infantile
Effectiveness of Point-of-use Water Treatment Technologies to Prevent Stunting Among Children in South Africa
This project is a community-based randomized controlled trial designed to test the effectiveness of two point-of-use water treatment technologies to improve clean drinking water access, reduce enteropathogen burden, and improve…
- Conditions
- Diarrhoea;Infectious;Presumed, Diarrhea, Infantile, Diarrhea Tropical, Environmental Exposure
- Trial name
- NCT03012048
- Testing
- Silver-impregnated ceramic tablet, Silver-impregnated ceramic water filter, Safe-storage water container
- Where
- South Africa
- Volunteers
- 415 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Early Esophageal Cancer
China Early Esophageal Cancer Cohort
With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery.
- Trial name
- NCT06515964
- Testing
- observational study
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Gastroenteritis
Impact of Rotavirus Vaccination on Hospital Pressures at a Large Paediatric Hospital in the UK: an Ecological Study
The impact of rotavirus vaccination on the burden of disease has been well documented. However, the anticipated reduction in hospital pressures has yet to be described.
- Trial name
- NCT03271593
- Testing
- No intervention
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Hypertrophic Pyloric Stenosis
Laparoscopic Versus Open Pyloromyotomy for Infants With Idiopathic Hypertrophic Pyloric Stenosis
Pyloric stenosis is a condition that develops in infants and that leads to an obstruction of the channel going out of the stomach.
- Trial name
- NCT00195949
- Testing
- Laparoscopic pyloromyotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Infliximab, Infusion
Infliximab Infusion Rates in Pediatric Inflammatory Bowel Disease
OBJECTIVES OF THE STUDY 1. Investigate whether there are just as few infusion reactions with infliximab infusions of 60 min and 30 min. 2. Investigate patient and nurse satisfaction with infusions of 60 min and 30 min. 3.
- Conditions
- Infliximab, Infusion, IBD (Inflammatory Bowel Disease), Patient Satisfaction
- Trial name
- iRAPID (NCT06839820)
- Testing
- Infusion rate of infliximab
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- University Hospital, Akershus
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