Clinical trials: GI Tract Disorders
Autism Spectrum Disorder
Effect of Probiotic Compound K11T e K11TMax in ASD
The research is characterized as a randomized, double-blind clinical trial (phase III) in which administered the probiotic K11-T (with and without added amino acids, fatty acids and vitamins) to children between 3 and 11 years…
- Trial name
- ASD (NCT06382909)
- Testing
- Inflammatory level, Cognitive assessment, Pedagogical assessment
- Where
- 2 sites in Brazil
- Volunteers
- 505 people
- Sponsor
- Deivis de Oliveira guimaraes
Urea Cycle Disorders
Clinical Food Study to Evaluate the Effect of KB195 on Gut Nitrogen Metabolism in Patients With Urea Cycle Disorders
This clinical food study aims to explore the effect of KB195, a novel mixture of oligosaccharides, on the metabolism of nitrogen by the microbiome in patients with urea cycle disorders (UCDs).
- Trial name
- NCT03797131
- Testing
- KB195 (a novel mixture of oligosaccharides)
- Where
- Switzerland
- Volunteers
- 4 people
- Sponsor
- Kaleido Biosciences
Attention-Deficit Hyperactivity Disorder, Unspecified Type, Autism Spectrum Disorder
A Multi-dimensional Prospective Study to Discover Gene-microenvironment Interactions in Neurodevelopmental Disorders
This project is the first involving the two most common neurodevelopmental disorders, ASD and ADHD, as well as TDC to establish a multi-dimensional database (clinic, behavior, neurocognitive function, brain imaging, metabolomics…
- Trial name
- NCT04878575
- Testing
- ASD diagnosis, Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Taiwan University Hospital
AML (Acute Myelogenous Leukemia, HLH
Gut Health in Children With Cancer
The purpose of this study is to observe the impact leukaemia treatment has on gut health (microbiomes) and how quickly the gut health recovers after leukamia treatment.
- Conditions
- AML (Acute Myelogenous Leukemia, HLH, Burkitt Lymphoma/Leukemia
- Trial name
- NCT06899581
- Testing
- Enteral nutrition Food Derived Ingredient
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Malnutrition
Mesalamine in Environmental Enteropathy
Undernutrition is one of the most important health issues in Kenya. Children who are chronically undernourished do not reach their full potential and are at increased risk of infectious disease.
- Trial name
- NCT01841099
- Testing
- Mesalamine
- Where
- Kenya
- Volunteers
- 44 people
- Sponsor
- Kelsey Jones
Malnutrition, Diarrhea
WASH Benefits Kenya
The purpose of this study is to measure the independent and combined effects of interventions that improve sanitation, water quality, handwashing, and nutrition on child health and development in the first years of life.
- Conditions
- Malnutrition, Diarrhea, Child Development
- Trial name
- WASHB-Kenya (NCT01704105)
- Testing
- Water Quality, Sanitation, Handwashing
- Where
- Kenya
- Volunteers
- 8,246 people, healthy volunteers welcome
- Sponsor
- Innovations for Poverty Action
Necrotizing Enterocolitis, Death
The Efficacy and Mechanisms of Oral Probiotics in Preventing Necrotizing Enterocolitis
The purpose of this study is to investigate the efficacy and its mechanisms of oral mixture probiotics in preventing necrotizing enterocolitis among the preterm very low birth weight infants.
- Trial name
- NCT02552706
- Testing
- probiotics, glucose solution
- Where
- 4 sites in China
- Volunteers
- 270 people
- Sponsor
- Shenzhen Bao'an Maternal and Child Health Hospital
Obesity, Diabetes
Treatment of Morbidly Obese Adolescent With a Duodena-jejunal Liner
Obesity and its complications have a significant effect on morbidity and mortality in these subjects. Especially at risk are subjects with extremely increased BMI (above 99th percentile for age and gender in adolescents).
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- NCT02183935
- Testing
- Duodena-jejunal liner
- Where
- Slovenia
- Volunteers
- 22 people
- Sponsor
- University Medical Centre Ljubljana
Prematurity, Intestinal Permeability
Intestinal Permeability in Preterm Infants
Necrotizing enterocolitis (NEC) is a life-threatening, gastrointestinal emergency characterized by increased intestinal permeability, affects approximately 7 to 10% of infants <1500 g birthweight, and typically occurs within 7 to…
- Trial name
- IPPI (NCT01756040)
- Testing
- Lactulose -rhamnose solution
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- University of Maryland, Baltimore
Primary Malignant Neoplasm of Lung, Primary Malignant Neoplasm of Gastrointestinal Tract
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Consecutive Cohort Study
To assess the feasibility of a creative writing intervention in an advanced cancer population. Given it is a relatively simple intervention delivered by a non-clinician, the investigators are interested in better understanding…
- Trial name
- NCT02575898
- Testing
- First Session, Second Session, Third through Sixth Sessions
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Cognitive Performance, Inflammation
Peanut Consumption on Cognitive, Weight, and Inflammation
A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight…
- Conditions
- Cognitive Performance, Inflammation, Weight Change, Body, Adolescents
- Trial name
- PEANUTY (NCT06127511)
- Testing
- Food (peanut)
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Crohn Disease
Pilot Study of Fundamental Modification of the Gut Microbiota in the Treatment of Refractory Crohn's Disease
The purpose of this study is to determine the effect of a novel gut microbiota-targeted therapeutic regimen (bowel lavage and antibiotics with or without an antifungal) in the management of active Crohn's Disease (CD) or…
- Trial name
- Holiday (NCT03476317)
- Testing
- Vancomycin, Neomycin, Ciprofloxacin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Microbial Colonization, Microbial Superinvasion
Metagenomic Analysis of Gut Microbiome in Preterm
This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and…
- Conditions
- Microbial Colonization, Microbial Superinvasion, Microbial Substitution, Newborn Morbidity
- Trial name
- MAGMP (NCT03235635)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Wonju Severance Christian Hospital
Zinc Deficiency, Mother and Child Malnutrition
Multi-Omic Profiling of a Zinc-Biofortified Maize Intervention in Guatemalan Mothers and Children
A trial evaluating the systemic and ecological impact of zinc-biofortified maize consumption on cellular zinc status, inflammatory biomarkers, and gut microbiota composition in a cohort of Guatemalan mothers and children.
- Trial name
- NCT07585318
- Testing
- F3 Biofortified Maize, Conventional Maize
- Where
- Guatemala
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute of Nutrition of Central America and Panama
Obesity, Childhood, Metabolic Syndrome
Gut Microbiome and Obesity
Pediatric obesity is a risk factor for the onset of obesity in adulthood and is a risk factor for various chronic non-communicable diseases.
- Trial name
- MATOMS (NCT04451148)
- Testing
- Obese with or without metabolic syndromesubjects
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Federico II University
Inflammatory Bowel Disease
Characterization of Phenotype and Genotype of Early Onset Enteropathies
This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies. In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early…
- Trial name
- IMMUNOBIOTA (NCT02614911)
- Testing
- Biological sampling
- Where
- 12 sites in France
- Volunteers
- 1,445 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Gastrointestinal Diseases
ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden)
The ESPRESSO study is a collection of data from all computerised gastrointestinal histopathology reports in Sweden. This allows us to study risk factors for gastrointestinal disease, as well as the prognosis of gastrointestinal…
- Trial name
- ESPRESSO (NCT06371820)
- Testing
- ESPRESSO [The study has no intervention]
- Volunteers
- 13,000,000 people
- Sponsor
- Karolinska Institutet
Fatty Liver
A Pilot Study to Explore the Role of Gut Flora in Fatty Liver
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Fatty Liver.
- Trial name
- NCT04160949
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Type 2 Diabetes (T2DM)
Influence of Gut Microbiota on the Development of Type 2 Diabetes Mellitus and Personalization of Diabetes-lowing Therapy
An observational, single-center, prospective study was conducted to examine the impact of CM on the development of T2DM and the personalization of initial SST in patients with newly diagnosed T2DM who had not previously received…
- Trial name
- GM (NCT07627048)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Pirogov Russian National Research Medical University