Clinical trials: GI Tract Disorders
Cows Milk Allergy
Synbiotics Cohort Study
Observational study exploring the clinical outcomes of infants with cow's milk allergy who are prescribed a hypoallergenic formula containing synbiotics.
- Trial name
- NCT05046418
- Testing
- Hypoallergenic formula containing synbiotics
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Nutricia UK Ltd
Microbiota, Gut Microbiome
Flourish: Exploring the Early Infant Gut Microbiome
The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months…
- Conditions
- Microbiota, Gut Microbiome, Eczema, Microbiome
- Trial name
- NCT07333482
- Testing
- Tailored Recommendations, Consult Call, Educational Email Series
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Anemia, Iron Deficiency
Iron and Prebiotics Fortification in Kenyan Infants
Iron deficiency and anemia are health issues affecting mainly infants and women in developing countries. Iron deficiency in infancy can have long-lasting impact on cognitive and motor development of the child.
- Conditions
- Anemia, Iron Deficiency, Diarrhea, Malaria
- Trial name
- Iro'n'Pre (NCT02118402)
- Testing
- Fortified maize porridge
- Where
- Kenya
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Chronic Hepatitis B Infection, Healthy
Study on Gut Microbiota in Chronic HBV Infected Patients
Hepatitis B Virus(HBV) infection is a common infectious disease affecting up to 2 billion people worldwide. Around 650 thousand people died of liver failure, cirrhosis and primary liver cancer caused by chronic hepatitis B every…
- Trial name
- HBV (NCT03587467)
- Testing
- collect fecal specimens
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhongshan Hospital Xiamen University
Morbid Obesity
Efficacy and Mechanism Study of Bariatric Surgery to Treat Moderate to Severe Obesity in Han Chinese Population
This is a long-term follow-up and interventional study in individuals who have been diagnosed with moderate to severe obesity with or without diabetes.
- Trial name
- NCT02653430
- Testing
- Sleeve gastrectomy
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Type 1 Diabetes
Prebiotic Fiber Supplement in T1DM Children
The gut microbiome is increasingly recognized as a contributor to disease states. In type 1 diabetes, alterations in gut microbiota may be linked to changes in intestinal permeability, inflammation and insulin resistance.
- Trial name
- NCT02442544
- Testing
- Prebiotic
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Calgary
Gastrointestinal Tract Infections, Respiratory Tract Infections
Bifidobacterium Animalis Subsp. Lactis in Prevention of Common Infections in Healthy Children Attending Day Care Centers
Hypothesis: Use of Bifidobacterium animalis subsp. lactis can effectively prevent common infections (gastrointestinal and respiratory) in healthy children who attend day care centre This study is a prospective, randomized, double…
- Trial name
- PROBBIC (NCT01702753)
- Testing
- Bifidobacterium animalis subsp. lactis
- Where
- Croatia
- Volunteers
- 250 people
- Sponsor
- Children's Hospital Zagreb
Gut Microbiota, Epilepsy
MiCrobiota-gut-brain Axis in Resistant Epilepsy
Epilepsy is one of the most common neurological chronic conditions with a serious burden on patients, their caregivers, and society. Drug-resistant epilepsy (DRE) heightens this burden. New approaches are thus a priority.
- Conditions
- Gut Microbiota, Epilepsy, Drug-Resistant Epilepsy
- Trial name
- CARE (NCT07010445)
- Testing
- Naïve: epilepsy first diagnosis,, DRE-surgery: resective surgery;, anti-epileptic drugs;
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Niguarda Hospital
Severe Malnutrition, Malnutrition
Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition
The investigators performed two case-control studies in Niger and Senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (SAM).
- Conditions
- Severe Malnutrition, Malnutrition, Infant Nutrition Disorders, Child Nutrition Disorders
- Trial name
- NCT02413905
- Testing
- Stool samples
- Where
- 2 sites in Niger, Senegal
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Hospitalo-Universitaire Méditerranée Infection
Obesity
Probiotics Effect on Glucose and Lipid Metabolism and Gut Microbiota in Patients With Obesity
The purpose of this study is to determine whether the probiotics will be effective in the treatment of obesity
- Trial name
- NCT02733484
- Testing
- Probiotics
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai 10th People's Hospital
Colorectal Cancer, Colorectal Neoplasms
A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Adenocarcinoma
- Trial name
- NCT04148378
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Intestinal Microbiota Between Different Groups
Impact of Direct-acting Antiviral Drugs on The Patterns of Gut Microbiota in Patients With HCV Related Chronic Liver Diseases
The recent introduction of direct-acting antiviral (DAA) therapy has dramatically changed the rates of cure of HCV infection even in difficult to treat subjects and in those with severe comorbidities .
- Trial name
- NCT06829966
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Iron Deficiency, Iron Deficiency Anemia
Effect of CFR and Iron Supplementation on Iron Status and Gut Microbiota of 1-2 Years Old Myanmar Children
Complementary feeding diet in developing countries cannot meet iron requirements of infants and young children. Iron supplementation is mostly used to treat iron deficiency whereas iron fortification is cost-effective strategy to…
- Trial name
- CFR (NCT01758159)
- Testing
- Iron supplementation, CFR
- Where
- Burma
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- SEAMEO Regional Centre for Food and Nutrition
Graft Vs Host Disease, Gastrointestinal Graft-Versus-Host Disease
Randomized Study of Oral Beclomethasone Dipropionate With Ten Days of Prednisone for Treatment of Gastrointestinal GVHD
Patients with gastrointestinal graft-vs.-host disease are randomized to oral beclomethasone dipropionate (BDP) 8 mg/day or identical placebo tablets for 50 days, along with a 10-day induction course of prednisone.
- Trial name
- NCT00233896
- Testing
- Oral beclomethasone dipropionate (drug)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Enteron Pharmaceuticals
Prebiotic, IBS (Irritable Bowel Syndrome)
Psyllium Husk in Pediatric IBS
Children aged 6 to 17 years with IBS will be randomly assigned to either receive psyllium husk supplementation in addition to usual care or receive usual care alone.
- Conditions
- Prebiotic, IBS (Irritable Bowel Syndrome), Psyllium, Quality of Life (QOL)
- Trial name
- NCT07880327
- Testing
- Psyllium Husk, Conventional therapy group
- Volunteers
- 70 people
- Sponsor
- Eman ElHaddad
Chronic Kidney Diseases
Effects of Resistant Starch Diet on the Gut Microbiome in Chronic Kidney Disease
The investigators want to learn more about how to help people who have chronic kidney disease (CKD). This study will increase the investigators understanding of how diet affects factors that can slow the progression of kidney…
- Trial name
- NCT03356990
- Testing
- Resistant Starch
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Arkansas
Amebiasis, Cryptosporidiosis
Parasitic Infections of the Gastrointestinal Tract
This protocol offers diagnosis and standard medical treatment for various parasitic gastrointestinal infections. Gastrointestinal parasites are either worms (helminths) or one-celled animals called protozoans which live in the…
- Conditions
- Amebiasis, Cryptosporidiosis, Giardiasis, Parasitic Disease
- Trial name
- NCT00001162
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Gastrointestinal Microbiome, Metabolome
Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)
This is an ancillary study to KIDFIT (NCT03405246). KIDFIT tests whether preschool-age children, born to overweight or obese mothers, respond to a healthy DASH diet intervention with better cardiovascular health.
- Conditions
- Gastrointestinal Microbiome, Metabolome, Pediatric Obesity, Dietary Approaches to Stop Hypertension
- Trial name
- NCT03612479
- Testing
- KIDFIT Healthy, KIDFIT Safe
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Northwestern University
Heathly Subjects Susceptible to SARS-CoV-2 Infection
Microbiome-Based Risk Prediction of SARS-CoV-2 in Children and Families (PREDICOL)
The goal of this observational cohort study is to evaluate the association between gut microbiota composition, dietary patterns, lifestyle-related factors, and neurodevelopmental outcomes, as well as susceptibility to SARS-CoV-2…
- Trial name
- PREDICOL (NCT07717008)
- Where
- Spain
- Volunteers
- 932 people, healthy volunteers welcome
- Sponsor
- Spanish National Research Council
Cow's Milk Protein Allergy (CMPA), Food Hypersensitivity
SMASH: Study to Evaluate the Clinical Efficacy of an Extensively Hydrolysed Infant Formula With Synbiotics and a Human Milk Oligosaccharide (HMO) in Infants With Cow's Milk Protein Allergy (CMPA)
Cow's milk protein allergy (CMPA) is one of the most common food allergies in infants, with an estimated prevalence between 2% and 5%.
- Conditions
- Cow's Milk Protein Allergy (CMPA), Food Hypersensitivity, Infant Nutrition Disorders, Gut Microbiota
- Trial name
- SMASH (NCT07342621)
- Where
- 13 sites in Spain
- Volunteers
- 41 people
- Sponsor
- Outcomes'10