Clinical trials: GI Tract Disorders
Rhinitis
Washed Microbiota Transplantation for Rhinitis
The common symptoms of rhinitis include nasal itching, sneezing, anterior or posterior nasal leakage, and nasal congestion. Rhinitis can be classified as allergic rhinitis (AR) and non-allergic rhinitis (NAR) based on the…
- Trial name
- NCT06350448
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Crohn Disease, Microtia
Clinical Study on the Distribution of Digestive Tract Microbiota Before and After Ileocecal Resection in Crohn's Disease
In this study, the microbiota sequencing was used to investigate the changes of microbiota in the terminal ileum and the middle part of ascending colon, the mesenteric adipose tissue of ileum and ascending mesocolon, and oral…
- Conditions
- Crohn Disease, Microtia, Ileocecal; Lesion
- Trial name
- NCT05615116
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Depression, Clinical Depression
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records
- Conditions
- Depression, Clinical Depression, Depression, Anxiety, Depression, Postpartum
- Trial name
- NCT04211467
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome
Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations.
- Conditions
- Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease
- Trial name
- NCT05212129
- Testing
- Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical College of Wisconsin
Metabolic Syndrome
Effects of Probiotics on Metabolic Syndrome ,Intestinal Microflora and SCFA.
The improvement effects of GLAC biotech probiotics contains 5 specialized strains on the biochemical analysis and gut microbiota will be verified in the clinical trial through cooperation with the ADPRC.
- Trial name
- NCT06183801
- Testing
- Probiotics 1, Probiotics 2, Probiotics 3
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- Glac Biotech Co., Ltd
Anorexia Nervosa
A Study on the Effects of Combined FMT on Gut Microbiota and Eating Disorder Symptoms in AN
The goal of this clinical trial is to determine if Fecal Microbiota Transplantation (FMT) is effective in treating Anorexia Nervosa (AN). The study will also explore how FMT works. The main questions it aims to answer are: 1.
- Trial name
- NCT06744751
- Testing
- Fecal Microbiota Transplantation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Mental Health Center
Autism, Autism Spectrum Disorder
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Autism
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding autism.
- Conditions
- Autism, Autism Spectrum Disorder, Autistic Disorder, Autism, Akinetic
- Trial name
- NCT04100863
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Crohn Disease, Inflammatory Bowel Diseases
Effect of Acupuncture on Patients With Crohn's Disease in Remission
To observe the therapeutic effect of acupuncture on Crohn's disease in remission and its influence of brain functional activity
- Trial name
- NCT04211129
- Testing
- acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Autism Spectrum Disorder, Gastrointestinal Dysfunction
ASC - Autism Study
The ASC - Autism Pilot Study is a single center randomized open dose titrating phase I clinical intervention pilot trial with the aim of investigating safety and treatment effect of an allogeneic adipose tissue derived…
- Conditions
- Autism Spectrum Disorder, Gastrointestinal Dysfunction, Leaky Gut Syndrome, Mesenchymal Stromal Cells
- Trial name
- NCT05602116
- Testing
- Adipose tissue derived mesenchymal stromal/stem cells (Cell2Cure®)
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Cell to Cure ApS
Ulcerative Colitis (UC)
Impact of the Novel UC-TREAT Diet on the Gut Microbiome and Its Acceptability in Healthy Adults and Adults With Quiescent Ulcerative Colitis
This will be an open-label dietary intervention study recruiting both healthy adults (≥16y) and adults with quiescent Ulcerative Colitis (UC).
- Trial name
- UC-TREAT (NCT06998277)
- Testing
- Dietary therapy
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Epilepsy
Precision Medicine in the Treatment of Epilepsy
Primary objectives: The purpose of this study is to identify single and composite biomarkers (from neuroimaging, electrophysiological, and non-imaging biological measures), clinical measures (from cognitive, psychometric, and…
- Trial name
- BDE (NCT05450822)
- Testing
- Levetiracetam, Levetiracetam Tablets, Lamotrigine tablet
- Where
- Denmark
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Gitte Moos Knudsen
Gut Microbiota Modulation
STUDY OF THE EFFECTS OF L. CASEI DG® (ENTEROLACTIS BABY) IN HEALTHY PRETERM AND FULL-TERM INFANTS.
The goal of this clinical trial was to learn whether giving Enterolactis Baby®, a probiotic food supplement containing Lactobacillus casei DG® (under the new taxonomical denomination: Lacticaseibacillus paracasei DG, CNCM…
- Trial name
- NCT07882537
- Testing
- Enterolactis Baby® drops
- Where
- Italy
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Alfasigma S.p.A.
Infantile Colic
The COLIC Study: Colonization of the Infant Gut With B. Infantis EVC001 to Reduce Symptoms of Colic
To investigate whether B. infantis EVC001 colonization in the infant gut can reduce symptoms of colic
- Trial name
- COLIC (NCT05129384)
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Evolve BioSystems, Inc.
Vitamin B 12 Deficiency
The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota
Vitamin B12 plays important roles in DNA synthesis and neurological functions. Vitamin B12 deficiency is one of the most common micronutrient deficiencies and it has become increasingly more frequent in infants.
- Trial name
- NCT03365583
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Marmara University
Obesity & Overweight
Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity
Glucagon-like peptide (GLP1) drugs have quickly become a standard treatment for the adults with obesity. These drugs target the appetite control center of the brain, which clows the rate of stomach emptying, and makes a person…
- Trial name
- GUT BOOST (NCT07823452)
- Testing
- gut-brain axis (GLP-1)-activating food carbohydrate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Indiana University
Respiration Disorders, Respiratory Disease
The Gut-Lung Axis and Respiratory Illness in Children
The goal of this single-centre observational study conducted at the Royal Hospital for Children in Glasgow, Scotland, is to employ a multi-omics approach to investigate the "gut-lung axis" in health and disease.
- Conditions
- Respiration Disorders, Respiratory Disease, Asthma in Children, Wheezing
- Trial name
- NCT06271213
- Testing
- observational only - no interventions as part of study
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Ulcerative Colitis
Personalized Anti-Inflammatory Fibres in Ulcerative Colitis
The goal of this clinical trial is to determine the clinical effects of two different dietary fibre supplements, acacia gum (AG) and microcrystalline cellulose (MCC), in patients with ulcerative colitis.
- Trial name
- PAIF-UC (NCT06515210)
- Testing
- Acacia Gum, Microcrystalline Cellulose
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- University of Alberta
Microbial Colonization, Antibiotic Side Effect
Timing of Maternal Antibiotic Prophylaxis During a Cesarean Section and the Early Infant Gut Microbiome
In this study, investigators seek to determine whether the timing of antibiotics given to mothers during an elective C-section affects the composition of their infant's gut microbiome.
- Conditions
- Microbial Colonization, Antibiotic Side Effect, Cesarean Section Complications
- Trial name
- CSBabyBiome (NCT06030713)
- Testing
- Cefazolin
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Gastrointestinal Disease, Inflammatory Bowel Disease (IBD)
Elemental 028 Extra Case Studies
Elemental 028 Extra is a nutritionally complete ACBS approved amino acid-based (elemental) feed designed to provide adequate daily amounts of both macronutrients and micronutrients when used as a sole source of nutrition and to…
- Conditions
- Gastrointestinal Disease, Inflammatory Bowel Disease (IBD), Short Bowel, Malabsorption
- Trial name
- E028E (NCT06877923)
- Testing
- Elemental 028 Extra
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Nutricia UK Ltd
Pediatric Crohns Disease
Clinical Hypnosis in Pediatric Crohn's Disease
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, immune-mediated disease increasingly prevalent in youth.
- Trial name
- HypnoCrohns (NCT03809195)
- Testing
- Clinical Hypnosis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center