Clinical trials: Gastro-Intestinal Disorders
Eosinophilic Esophagitis
A Prospective Study of the Four Food Elimination Diet for Treatment of Eosinophilic Esophagitis
This study is to observe the efficacy of the four food elimination diet.
- Trial name
- NCT05176262
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Fatty Liver
Randomized Study of the Use of Intravenous Choline Supplementation in Long Term Total Parenteral Nutrition
OBJECTIVES: I. Determine whether intravenous choline supplementation will reverse the hepatic steatosis and improve liver function in patients who receive long term total parenteral nutrition.
- Trial name
- NCT00004697
- Testing
- choline chloride
- Volunteers
- 15 people
- Sponsor
- University of Texas
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Adolescent
Effect of ACTIVE-Care on Cancer-Related Fatigue, Hope, and Psychological Resilience in Adolescents With Acute Lymphoblastic Leukemia
This study aimed to evaluate the effects of the ACTIVE-Care Integrated Physical Activity-Based Supportive Care Program on cancer-related fatigue, hope, and psychological resilience in adolescents with acute lymphoblastic leukemia…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Adolescent, Resilience, Psychological, Physical Activities
- Trial name
- NCT07882069
- Testing
- ACTIVE-Care Integrated Physical Activity-Based Supportive Care Program
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Selcuk University
Bladder Cancer, Triple Negative Breast Cancer
A Phase I/IIa Trial of HMBD-001 in Advanced HER3 Positive Solid Tumours
This clinical trial is evaluating a drug called HMBD-001 (an anti-HER3 monoclonal antibody) in participants with advanced HER3 positive solid tumours.
- Conditions
- Bladder Cancer, Triple Negative Breast Cancer, Castration-resistant Prostate Cancer, Cervical Cancer
- Trial name
- NCT05057013
- Testing
- HMBD-001, HMBD-001 and enzalutamide
- Where
- 4 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cancer Research UK
Brief Resolved Unexplained Event, Apparent Life Threatening Event
Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event
This observational study will examine the effects of thickened feeds on clinical outcomes and healthcare utilization in infants with brief resolved unexplained event (BRUE).
- Conditions
- Brief Resolved Unexplained Event, Apparent Life Threatening Event, Oropharyngeal Dysphagia
- Trial name
- BRUE (NCT04477460)
- Testing
- Thickened feeds, Non-thickened feeds
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Children's Hospital
Psoriasis
Post-Marketing Surveillance Study of OTEZLA
To evaluate the safety and efficacy of OTEZLA in actual clinical settings of use in patients with Psoriasis vulgaris that is with an inadequate response to topical therapies and Psoriasis arthropathica 1.
- Trial name
- NCT03284879
- Where
- Japan
- Volunteers
- 1,086 people
- Sponsor
- Amgen
Eosinophilic Esophagitis
Dietetic Versus Topical Steroids for Pediatric Eosinophilic Esophagitis
Therapeutic strategies for eosinophilic esophagitis (EoE) actually include: 1) allergen avoidance through dietary modifications, and 2) pharmacologic antiinflammatory therapy.
- Trial name
- NCT01846962
- Testing
- Budesonide, Fluticasone, six-foods elimination diet
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Policlinico Umberto I
Glioblastoma, Squamous Cell Carcinoma
Expanded Access to Immunomodulatory AVM0703 for Solid Tumor and Blood Cancer Patients
AVM Biotechnology, Inc., provides immunomodulatory AVM0703 to solid tumor and blood cancer patients upon request by a US licensed MD or DO.
- Conditions
- Glioblastoma, Squamous Cell Carcinoma, Hodgkin Lymphoma, Non-hodgkin Lymphoma
- Trial name
- NCT05974410
- Testing
- AVM0703, Hydrocortisone, Proton pump inhibitor
- Sponsor
- AVM Biotechnology Inc
Gastro-Intestinal Disorders
Effects of Passive Smoking on Children During Gastrointestinal Endoscopy
To evaluate the effect of passive smoking in children during Gastrointestinal Endoscopy.
- Trial name
- NCT03920046
- Testing
- Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 518 people
- Sponsor
- TC Erciyes University
Colorectal Cancer (CRC), Pancreatic Cancer
Expanded Access Program (EAP) Designed to Provide Access to Botensilimab and Balstilimab Before Regulatory Approval
This is an expanded access program (EAP) designed to provide access to Botensilimab and Balstilimab prior to drug registration by the applicable local regulatory agency.
- Conditions
- Colorectal Cancer (CRC), Pancreatic Cancer, Non-Small Cell Lung Cancer (NSCLC), Hepatocellular Carcinoma (HCC)
- Trial name
- NCT06751524
- Testing
- Botensilimab, Balstililmab
- Sponsor
- Agenus Inc.
Autism Spectrum Disorder, Eosinophilic Gastrointestinal Disorders
Umbilical Cord Blood Therapy in a Child With Eosinophilic Duodenitis and Autism Spectrum Disorder: a Case Study
This single-case exploratory clinical study aims to evaluate the therapeutic potential of umbilical cord blood (UCB) infusion in a pediatric patient diagnosed with both eosinophilic duodenitis (ED) and autism spectrum disorder…
- Trial name
- NCT06995274
- Testing
- Umbilical Cord Blood Infusion (Autologous and Allogeneic)
- Volunteers
- 1 people
- Sponsor
- Bundang CHA Hospital
Asthma, Gastroesophageal Reflux
Importance of Non-Acid Reflux in Asthma in Children
The purpose of the study is to follow the medical course of children with moderate to severe asthma and see how this relates to whether they have acid of non-acid gastroesophageal reflux
- Trial name
- NCT00200980
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Nemours Children's Clinic
Henoch-Schönlein Purpura, Gastrointestinal Injury
Mycophenolate Mofetil in Gastrointestinal Henoch-Schonlein Purpura
Henoch Schönlein purpura (HSP) is the most common type of vasculitis in children, with an incidence of ~10/100,000, whereas >90% of the patients develop symptoms at <10 years of age.
- Conditions
- Henoch-Schönlein Purpura, Gastrointestinal Injury, Mycophenolate Mofetil
- Trial name
- NCT05951517
- Testing
- MMF
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm
Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study
This phase Ib trial investigates the side effects of the combination of nivolumab and ipilimumab, and to see how well they work in treating patients with cancers that have come back (relapsed) or does not respond to treatment…
- Conditions
- Constitutional Mismatch Repair Deficiency Syndrome, Hematopoietic and Lymphoid Cell Neoplasm, Lynch Syndrome, Recurrent Lymphoma
- Trial name
- NCT04500548
- Testing
- Biospecimen Collection, Ipilimumab, Nivolumab
- Where
- 9 sites in United States, Canada
- Sponsor
- National Cancer Institute (NCI)
Vocal Fold Palsy, Dysphagia
Universal Screening for Vocal Fold Motion Impairment in Children Undergoing Congenital Cardiac Surgery
The purpose of this study is to determine how often heart or chest surgery in children leads to problems with the movement of the vocal folds.
- Conditions
- Vocal Fold Palsy, Dysphagia, Congenital Heart Disease in Children
- Trial name
- NCT03882450
- Testing
- Flexible fiberoptic laryngoscopy, Laryngeal ultrasonography
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Emory University
Mucositis, Graft-versus-host Disease
Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX
A comparative trial where all patients will receive daily doses of tacrolimus (TAC) until day +60 when tapering will begin, in the absence of graft-versus-host disease (GVHD), and discontinued by day +180.
- Trial name
- NCT00360685
- Testing
- Tac+MTX, TAC + MMF
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastroesophageal Reflux Disease, Hiatal Hernia
Necessity of Esophageal Dissection During Laparoscopic Fundoplication
This study compares complete dissection of the tissue around the lower esophagus to no dissection of these tissues during laparoscopic fundoplication in children.
- Trial name
- NCT00287612
- Testing
- Lap. Fundo. with Mobilization of the Esophageal Junction, Lap. Fundo. without Mobilization of the Esophageal Junction
- Where
- 2 sites in United States
- Volunteers
- 177 people
- Sponsor
- Children's Mercy Hospital Kansas City
IBS, Functional Gastrointestinal Disorders
Efficacy of a Low FODMAP Diet in IBS Children and Impact on Urinary and Faecal Metabolome
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain associated with defecation, or changes in stool frequency or stool form .
- Trial name
- NCT06618677
- Testing
- LOW FODMAPs Diet
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Bari
Alcohol Abuse, Drug Abuse
Reducing Problematic Substance Use in Youth With Chronic Medical Conditions
The investigators goal is to pilot a substance use-related brief intervention (BI) for youth with chronic medical conditions, obtaining preliminary evidence of feasibility, acceptability and impacts of the approach for reducing…
- Trial name
- NCT01709201
- Testing
- Brief Intervention
- Where
- United States
- Sponsor
- Boston Children's Hospital
Eosinophilic Esophagitis
EDN and Eosinophilic Esophagitis
Eosinophilic esophagitis is a recent and emerging chronic disease, secondary to eosinophilic infiltration of the esophageal mucosa leading to esophageal dysfunction.
- Trial name
- OesEDN (NCT06387030)
- Testing
- Blood sampling, Esophageal biopsies, Unstimulated saliva sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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