Clinical trials: Gastro-Intestinal Disorders
GERD
Effect of Helicobacter Pylori Eradication on Gastroesophageal RefIux Disease (GERD)
Evaluate the effect of H.pylori eradication on Gastroesophageal-reflux disease and symptoms improvement
- Trial name
- NCT06457334
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Probiotics, Infant, Newborn
Probiotics Supplementation and Intestinal Microbiome in Neonates With Gastrointestinal Surgery
Congenital defects of the gastrointestinal tract commonly require surgical intervention in the neonatal period. Intestinal surgery during this critical period of microbiome acquisition results in aberrant colonization of the…
- Conditions
- Probiotics, Infant, Newborn, Surgical Procedures, Operative, Gastro-Intestinal Disorder
- Trial name
- ProPS (NCT03266315)
- Testing
- FloraBaby
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Calgary
Vomiting, Feeding Disorders
Use of Intrapyloric Botulinum Injections in Children
This study aims to evaluate the effect of intrapyloric botulinum toxin in children with feeding disorders.
- Conditions
- Vomiting, Feeding Disorders, Gastroparesis
- Trial name
- NCT04250844
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Achalasia, Epidermoid Carcinoma
Epidermoid Cancer Development in Esophageal Achalasia
Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined.
- Trial name
- NCT03546998
- Testing
- Clinical instrumental examinations
- Where
- Italy
- Volunteers
- 681 people
- Sponsor
- Sandro Mattioli
Hepatic Cancer, Pancreatic Ductal Cancer
The Natural History of Solid Organ Cancer Stem Cells (SOCSC)
Background: Researchers are trying to learn what causes certain types of cancer to spread to other organs in the body (metastasis).
- Conditions
- Hepatic Cancer, Pancreatic Ductal Cancer, Colorectal Cancer, Breast Cancer
- Trial name
- NCT00923052
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- National Cancer Institute (NCI)
Dehydration, Seizure
Point of Care Device Use in the Pediatric Emergency Department
To compare the effect of "point-of-care" (POC) analysis of blood work with traditional laboratory methods on length of stay in a pediatric emergency department (PED).
- Conditions
- Dehydration, Seizure, Gastroenteritis, Hyperglycemia
- Trial name
- NCT00285285
- Testing
- Point of Care Device; i-Stat Analyzer
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University
HIV
Tolerability of Lopinavir Versus Dolutegravir for Children and Adolescents Living With HIV
Dolutegravir-based antiretroviral therapy is set to be increasingly replace ritonavir-boosted lopinavir-based regimens for the treatment of paediatric HIV.
- Trial name
- LoDoCA (NCT05426421)
- Where
- Lesotho
- Volunteers
- 258 people
- Sponsor
- Swiss Tropical & Public Health Institute
Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS)
Pain in Pediatric Patients - Internet Interventions for Disorders of Gut-brain Interaction
Many children and adolescents often experience long-lasting stomach pain. In many cases, this is due to disorders of gut-brain interaction (DGBI), such as irritable bowel syndrome (IBS), functional abdominal pain, and functional…
- Conditions
- Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS), Functional Dyspepsia
- Trial name
- PIPPI (NCT07319078)
- Testing
- Gut-directed hypnotherapy, Cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Eosinophilic Esophagitis
A Study of Benralizumab in Patients With Eosinophilic Esophagitis
The aim of this Phase 3 study is to investigate the use of benralizumab as a treatment for patients with EoE. The effect of doses of benralizumab on EoE histologic signs and symptoms will be assessed over a 52-week treatment…
- Trial name
- MESSINA (NCT04543409)
- Testing
- Benralizumab
- Where
- 78 sites in United States, Canada and 10 more
- Volunteers
- 211 people
- Sponsor
- AstraZeneca
Chronic Lung Disease
A Pilot Study of Pulmonary Function in Dysphagic Infants
Infants less than 2 years old who have been newly diagnosed with problems swallowing will have pulmonary function tests performed to try to detect the presence of chronic lung disease.
- Trial name
- NCT00831038
- Testing
- Infant Pulmonary Function Tests
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Attention Deficit Disorder With Hyperactivity, Gastrointestinal Diseases
The Prevalence and Predictors of Gastrointestinal Symptoms in Children With Attention Deficit / Hyperactivity Disorder
This study is to examine the gut problems in children with attention deficit hyperactivity disorders (ADHD) and is conducted by the Department of Psychiatry of Alice Ho Miu Ling Nethersole Hospital.
- Trial name
- NCT03879343
- Testing
- Known diagnosis of attention deficit / hyperactivity disorder
- Where
- Hong Kong
- Volunteers
- 142 people
- Sponsor
- Hospital Authority, Hong Kong
Severe Malnutrition, Enteritis
Hypoallergenic and Anti-inflammatory Feeds in Malawian Children With Severe Acute Malnutrition (SAM)
Children with complicated severe acute malnutrition (SAM), such as inability to take adequate feeds, infection and diarrhoea, require in-patient management.
- Trial name
- SAM (NCT02639416)
- Testing
- Polymeric formula, Elemental formula, Standard management
- Where
- Malawi
- Volunteers
- 95 people
- Sponsor
- Liverpool School of Tropical Medicine
Early T Acute Lymphoblastic Leukemia, T-Acute Lymphoblastic Leukemia
Venetoclax + Azacytidine for Newly Diagnosed ETP-like ALL and T-ALL With Myeloid Mutations
The goal of this clinical trial is to evaluate the efficacy and safety of venetoclax combined with azacitidine in treating newly diagnosed early T-cell precursor (ETP)-like acute lymphoblastic leukemia (ALL), T-ALL with myeloid…
- Conditions
- Early T Acute Lymphoblastic Leukemia, T-Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia, T/Myeloid, Nos
- Trial name
- NCT07012447
- Testing
- Venetoclax, Azacitidine, Cytarabine
- Where
- China
- Volunteers
- 32 people
- Sponsor
- yuejun Liu
Achlorhydria, Gastrinoma
Evaluating Patients With Abnormal Levels of Gastric Acid
This study is used by the Digestive Diseases Branch to evaluate patients with suspected abnormalities in the secretion of gastric acid.
- Conditions
- Achlorhydria, Gastrinoma, Zollinger Ellison Syndrome
- Trial name
- NCT00001240
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Gastroesophageal Reflux Disease
A Prospective Randomized Trial Comparing Laparoscopic Nissen Against Anterior Partial Fundoplication in Treating Gastroesophageal Reflux Disease Among Chinese Patients
The aim of this study is to compare the effectiveness of laparoscopic Nissen against anterior partial fundoplication in the control of gastroesophageal reflux disease among Chinese patients Study hypothesis Laparoscopic Nissen is…
- Trial name
- NCT00480285
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic anterior partial fundoplication
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Gastro-Oesophageal Reflux
Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery
The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children.
- Trial name
- NCT00231543
- Testing
- Laparoscopic fundoplication, open Nissen fundoplication
- Where
- United Kingdom
- Sponsor
- Institute of Child Health
Acute Kidney Injury, Hypoxia-Ischemia, Brain
Tissue Oxygenation During Treatment of Infant Congenital Heart Defects
Background: Acute kidney injury (AKI) is a common and serious postoperative complication in children with congenital heart disease.
- Conditions
- Acute Kidney Injury, Hypoxia-Ischemia, Brain, Mesenteric Ischemia
- Trial name
- NCT03941015
- Where
- China
- Volunteers
- 245 people
- Sponsor
- Beijing Anzhen Hospital
Antibiotic-associated Loose/Watery Stools
Efficacy and Safety of a Probiotic Product in Children With Antibiotic-associated Gastrointestinal Disorders.
To assess the tolerability and effect of a probiotic product, when co-administered with antibiotics, on the incidence and duration of loose/watery stools following the antibiotic treatment in children.
- Trial name
- NCT01940913
- Testing
- Probiotic capsules
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Probi AB
Down Syndrome, Dysphagia, Oropharyngeal
Pulmonary Health in Children With Down Syndrome
The goal of the study is to learn more about tests that can assess lung health in children with Down syndrome.
- Trial name
- NCT04398862
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Colorado, Denver
Swallowing Disorder, Perinatal Asphyxia
Effect of Non-nutritive Sucking on Transition to Oral Feeding in Infants With Asphyxia
The transition period to full oral feeding in infants with perinatal asphyxia is important in predicting long-term outcomes. The transition to independent oral feeding is accepted as a discharge criterion by the American Academy…
- Conditions
- Swallowing Disorder, Perinatal Asphyxia, Feeding; Difficult, Newborn, Feeding Disorder of Infancy or Early Childhood
- Trial name
- NCT05687708
- Testing
- Non-Nutritive Sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medipol University
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