Clinical trials: Gastrointestinal Health
Cystic Fibrosis
Improving Adherence and Clinical Outcome in Cystic Fibrosis (CF) Patients
The purpose of this study is to assess the impact of a collaborative active intervention program of a multi-disciplinary team on improving adherence to chronic medications and improve clinical outcomes in CF patients.
- Trial name
- NCT01025258
- Testing
- Frequent Scheduled CF clinic visits, frequent telephone calls to patients pre and post visits to the clinic
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Sheba Medical Center
Cerebral Palsy, Melatonin
Melatonin for Cerebral Palsy Children's Sleep and Health
The present study was prospective uncontrolled, single-armed and un-blinded study. Held in the Pediatric neurology clinic, Children's hospital l, Faculty of Medicine, Ain Shams University from June 2016 to June 2018 of 24 months…
- Conditions
- Cerebral Palsy, Melatonin, Growth, Children, Only
- Trial name
- NCT04392063
- Testing
- Melatonin 3 mg
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hepatitis C and B VIRUS Screening, Awareness and Behavior Assessment and Evaluation for All Inhabitants Above Twelve Years of Al Othmaneya Village
Effect of Implementation Of Outreach Behavioral Change Program for HCV Elimination
Elimination of hepatitis C virus (HCV) is the process of stopping sustained transmission of viral hepatitis, reducing its incidence to zero and providing access to safe, affordable and effective treatment and care for everyone.
- Trial name
- NCT03415334
- Testing
- behavioral development for change
- Volunteers
- 3,575 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Celiac Disease in Children
"Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve Early Diagnosis of Celiac Disease"
Celiac Disease (CD) is an immune-mediated systemic disorder elicited by the ingestion of gluten containing cereals from the normal diet, among others wheat, rye and barley.
- Trial name
- GLUTEN-GEN (NCT06179121)
- Testing
- DNA test for screening HLA-DQ2 and DQ8 from dried blood spots to early detect Celiac Disease
- Where
- Netherlands
- Volunteers
- 508 people
- Sponsor
- Leiden University Medical Center
Inflammatory Bowel Diseases, Crohn Disease
Implementing a Multimodal RCT Intervention to Improve the Transition of Patients With Crohn's Disease From Pediatric to Adult Care
Background: Transition in care is defined as the "purposeful and planned movement of adolescents and young adults with a chronic medical condition from pediatric to adult-oriented healthcare systems/care providers." Currently…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Adolescent Development
- Trial name
- NCT05221281
- Testing
- Multimodal intervention consisting of four core components, Standard of care
- Where
- 3 sites in Canada
- Volunteers
- 90 people
- Sponsor
- The Hospital for Sick Children
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Inflammatory Bowel Disease
Physical Activity and Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
This study is an observational study. The purpose of this study is to assess the relationship between bone health and daily physical activity in children and adolescents with inflammatory bowel disease (IBD).
- Trial name
- PHYSICOSMICI (NCT02341742)
- Testing
- multiple examinations
- Where
- 7 sites in France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Lille
Colorectal Cancer
Use of Telehealth In-home Messaging to Improve GI (Gastrointestinal) Endoscopy Completion Rates
Low endoscopy completion rates are a major problem in the VA, causing delay or failure to receive essential care, increased clinic wait times, lost capacity, increased costs, thus limiting endoscopic screening for colorectal…
- Trial name
- GIVER (NCT00310362)
- Testing
- Use of Interactive Voice Response (IVR) system to improve adherence to GI appointments and prep procedures
- Where
- United States
- Volunteers
- 3,610 people
- Sponsor
- VA Office of Research and Development
Cystic Fibrosis
Bone Health of People With Cystic Fibrosis
People with cystic fibrosis (CF) now frequently live into adulthood and with this extended life expectancy has come new clinical problems.
- Trial name
- NCT00008762
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Peri-Implant Health, Peri-Implantitis and Peri-implant Mucositis
Monitoring of Implant Diseases: Diagnosis and Monitoring With aMMP-8 Test Technology
68 patients underwent the aMMP-8 chair-side test as well as clinical traditional measurement methods. Those who had one or more implants in their mouth were selected as patients.
- Trial name
- IMP_TRE (NCT06761521)
- Testing
- Peri-Implantitis and Peri-implant mucositis
- Where
- Finland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hanna Lahteenmaki
Shigella, Child
Enterics for Global Health (EFGH)
Diarrhea remains a leading cause of death among young children, with the majority of diarrhea deaths occurring in low- and middle-income countries.
- Conditions
- Shigella, Child, Diarrhea
- Trial name
- EFGH (NCT06047821)
- Where
- 33 sites in Bangladesh, Kenya and 5 more
- Volunteers
- 9,800 people
- Sponsor
- University of Washington
Inflammatory Bowel Diseases, Mental Health Issue
IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD
People with Inflammatory bowel disease (IBD) can get challenging symptoms. Things like diarrhoea, tummy pain and being tired all the time are common. People often get IBD in their teens or twenties.
- Trial name
- IBDminds (NCT07175454)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Inflammatory Bowel Disease, Crohn Disease
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls.
- Trial name
- NCT04508088
- Testing
- Coronal T1 weighted spin echo images, Spin-lattice relaxation (T1), Magnetic resonance spectroscopy
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Cystic Fibrosis
Tele-Coaching Intervention to Improve Treatment Adherence in Cystic Fibrosis
This is a prospective, multicenter pilot study to investigate the feasibility and preliminary effectiveness of a tailored tele-coaching intervention to enhance medical adherence in patients with CF.
- Trial name
- NCT03921229
- Testing
- Tele-coaching
- Where
- 6 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Colon Cancer
The Impact of Palm Date Intake on Colon Health Biomarkers
This aim of this study is to investigate the prebiotic potential of date fruits in healthy human volunteers compared to a control diet. Each arm was 21 days in duration, separated by a 14 days washout period.
- Trial name
- AJWA (NCT02288611)
- Testing
- Date fruit - Ajwa variety, Maltodextrin/Dextrose
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Reading
Infant Development, Healthy
Prebiotic EffecT InfanTs
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on stool consistency in infants.
- Conditions
- Infant Development, Healthy, Diet, Healthy
- Trial name
- PETIT (NCT04791956)
- Testing
- Prebiotic
- Where
- 2 sites in Spain
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Allogeneic Stem Cell Transplantation
Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant
Bloodstream infections (BSI) caused by bacteria translocating across injured oral mucosa are a significant cause of morbidity and mortality in patients undergoing stem cell transplantation (SCT).
- Trial name
- NCT05579639
- Testing
- Xylitol
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Intestinal Diseases, Parasitic
Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Women of reproductive age are considered a high-risk group for worm infections by the World Health Organization. Maternal infection and anemia contribute to infant malnutrition by affecting milk quality and quantity, and duration…
- Trial name
- NCT01748929
- Testing
- Albendazole
- Where
- Peru
- Volunteers
- 1,010 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre