Clinical trials: Gastroschisis
Gastroschisis
Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis
Gastroschisis is a congenital defect of the abdominal wall that leads to evisceration of various amounts of the abdominal organs.
- Trial name
- NCT03355326
- Testing
- Glycerin Suppository
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastroschisis
Evaluating the Use of a Silastic Spring-Loaded Silo for Infants With Gastroschisis
This study seeks to evaluate whether the routine, primary use of the spring-loaded silo (SLS) to treat infants with gastroschisis will result in improved outcomes, faster recovery times and fewer post-surgical complications than…
- Trial name
- NCT00539292
- Testing
- Primary placement of a spring-loaded silo, Primary Closure
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- The Hospital for Sick Children
Gastroschisis, Anorectal Malformation
Children's Surgery in Sub-Saharan Africa
Background: Five billion people worldwide do not have access to safe, affordable surgical care. A significant proportion live in sub-Saharan Africa (SSA), where up to 50% of the population are children.
- Conditions
- Gastroschisis, Anorectal Malformation, Appendicitis, Intussusception
- Trial name
- PaedSurgAfrica (NCT03185637)
- Testing
- Various interventions for each of the conditions.
- Where
- United Kingdom
- Volunteers
- 1,407 people
- Sponsor
- King's College London
Gastroschisis, Bowel Obstruction
The Use of Gastrografin to Help Alleviate Bowel Obstruction in Gastroschisis Patients.
This study will investigate the use of a drug called Gastrografin to aid in bowel mobility for paediatric patients who have undergone gastroschisis surgery.
- Conditions
- Gastroschisis, Bowel Obstruction, Birth Defect
- Trial name
- NCT03334578
- Testing
- Gastrografin
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Gastroschisis
Multi-Centre Gastroschisis Interventional Study Across Sub-Saharan Africa
This study is a multi-centre interventional study at seven tertiary paediatric surgery centres in Ghana, Zambia, Malawi and Tanzania aimed at reducing mortality from gastroschisis.
- Trial name
- NCT03724214
- Testing
- Pre-hospital interventional care bundle, In-hospital interventional care bundle
- Where
- 9 sites in Canada, Ghana and 4 more
- Volunteers
- 235 people
- Sponsor
- King's College London
Oesophageal Atresia, Congenital Diaphragmatic Hernia
Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries
This study is a multi-centre, international, prospective cohort study of congenital anomalies to compare outcomes between LMICs and high-income countries (HICs) globally.
- Conditions
- Oesophageal Atresia, Congenital Diaphragmatic Hernia, Intestinal Atresia, Gastroschisis
- Trial name
- NCT03666767
- Testing
- Comparisons will be made between LMICs and HICs
- Where
- United Kingdom
- Volunteers
- 3,850 people
- Sponsor
- King's College London
Gastroschisis
Probiotics in Infants With Gastroschisis
Infants born with gastroschisis usually require surgery shortly after birth. After surgery the intestine is often unable to digest human milk or formula for weeks or months.
- Trial name
- NCT01316510
- Testing
- Bifidobacteria infantis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Davis
Diaphragmatic Eventration
Diaphragmatic Eventration in Children : Evaluation of Care Strategies and Results in the French Cohort.
A diaphragmatic eventration is an abnormal and permanent elevation of a portion or an entire intact hemidiaphragm. This rare pathology, found in 0.2 - 1 for every 1000 patients in large radiological series, is either congenital…
- Trial name
- PedDiaVen (NCT04862494)
- Testing
- clinical surveillance, diaphragmatic plication
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Gastroschisis
Early Feeds in Gastroschisis
This study aims to evaluate the feasibility of initiating early feeds in neonates with gastroschisis, a condition where infants are born with their intestines outside the body.
- Trial name
- GAIN (NCT06878950)
- Testing
- Early Feeding Protocol
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Gastroschisis
Metoclopramide Pilot Trial
Infants with gastroschisis typically have poor intestinal motility for the first weeks to months after birth. Prokinetic agents are often used in these infants to improve intestinal motility in an attempt to quicken the…
- Trial name
- NCT02098915
- Testing
- intravenous metoclopramide
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- The Hospital for Sick Children
Gastroschisis, Intestinal Ischemia
Regional Blood Saturation Levels in Gastroschisis
Gastroschisis is one of the most common neonatal surgical conditions, and is increasing in incidence. Postnatal bowel ischemia leading to necrosis, bowel loss and short-bowel syndrome, occurs in a few instances, with significant…
- Trial name
- NCT03533439
- Testing
- Near infrared spectroscopy
- Volunteers
- 19 people
- Sponsor
- NHS Lothian
Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration
Genetic Analysis of Congenital Diaphragmatic Disorders
The purpose of this study is to understand the genetic causes of congenital diaphragmatic disorders (CDD), namely congenital diaphragmatic hernia (CDH), eventration and hiatal hernia. Specifically, the investigators plan to: 1.
- Conditions
- Congenital Diaphragmatic Hernia, Congenital Diaphragmatic Eventration, Congenital Hiatal Hernia, Congenital Diaphragmatic Disorders
- Trial name
- NCT01243229
- Where
- 2 sites in United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Utah
Intestinal Obstruction, Gastroschisis
Ostomy in Continuity or Conventional Ileostomy: a Retrospective Multicentric Analysis
Surgical procedures for complex intestinal neonatal and paediatric diseases may require the use of an ostomy, in order to discharge the upper intestine.
- Conditions
- Intestinal Obstruction, Gastroschisis, Enterocolitis, Necrotizing, Hirschsprung Disease
- Trial name
- StomaPed (NCT04213976)
- Testing
- Ileostomy
- Where
- 5 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers
Enterocolitis, Necrotizing, Atresia; Bowel
Timing of Stoma Closure in Neonates
Some babies require emergency surgery on their tummy in the first few months of life. This is most commonly because they were born prematurely and developed a bowel problem (called NEC) or a blockage of the bowel.
- Conditions
- Enterocolitis, Necrotizing, Atresia; Bowel, Gastroschisis, Meconium Ileus
- Trial name
- ToSCiN (NCT04713579)
- Testing
- No intervention - observational study
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Manchester University NHS Foundation Trust
Gastroschisis, Congenital Diaphragmatic Hernia
An Exploratory Physiological Study of Post-operative Recovery in Surgical Neonates and Dimethylarginine:Arginine Levels
The SuNDiAL study will measure levels of two naturally occurring amino acids: Arginine and Asymmetric Dimethylarginine (ADMA) in neonates undergoing abdominal surgery in the first 5 days of life due to congenital abdominal…
- Conditions
- Gastroschisis, Congenital Diaphragmatic Hernia, Duodenal Atresia, Oesophageal Atresia With Tracheo-Oesophageal Fistula
- Trial name
- SuNDiAL (NCT06731855)
- Testing
- Abdominal Surgery for congenital gut malformation in the first 5 days of life.
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Liverpool Women's NHS Foundation Trust
Total Parenteral Nutrition-induced Cholestasis, Cholestasis
Compassionate Use of Omegaven in Children
This is a single-assignment study to evaluate whether Omegaven (IV fish oil) is effective at treating liver disease in children on long-term IV nutrition.
- Conditions
- Total Parenteral Nutrition-induced Cholestasis, Cholestasis, Short Bowel Syndrome, Gastroschisis
- Trial name
- NCT02370251
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- University of Oklahoma
Gastrointestinal Complication, Intestinal Obstruction
The Influence of Feeding Source on the Gut Microbiome and Time to Full Feeds in Neonates With Congenital Gastrointestinal Pathologies
This study explores the use of an exclusive human milk diet versus standard feeding practices to compare the influence on feeding outcomes and the gut bacteria in infants with intestinal differences.
- Conditions
- Gastrointestinal Complication, Intestinal Obstruction, Gastroschisis, Hirschsprung Disease
- Trial name
- NCT06072976
- Testing
- Standard of Care, Exclusive Human Milk
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Seattle Children's Hospital
Gastroschisis
Clinical and Biological Outcomes of Human Milk and Formula Intake After Gastroschisis Repair
The purpose of this study is to determine which type of food results in a shorter hospital stay and better overall outcome for babies born with gastroschisis.
- Trial name
- NCT02575846
- Testing
- Enteral Intake - Human Milk, Enteral Intake - Formula
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Gastroschisis
Sutureless vs Sutured Gastroschisis Closure
This study aims to prospectively assess outcomes of sutureless versus sutured gastroschisis closure with a randomized control trial. The parameters of this trial were determined using our retrospective study as pilot data.
- Trial name
- NCT01094587
- Testing
- Gastroschisis closure with suture, Gastroschisis closure without suture
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Stanford University
Gastroschisis
Bedside Silo Versus Operative Closure for Gastroschisis
The hypothesis is that there is no difference between bedside silo placement and operative closure in return of bowel function, ventilator dependence, or length of stay.
- Trial name
- NCT00404690
- Testing
- Bedside Silo, Operative attempt at closure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Mercy Hospital Kansas City