Clinical trials: Gene Polymorphism
Puberty, Precocious
Kisspeptin/GPR54 Pathway and Early Puberty
There was a worldwide early trend in girls'age for puberty onset. The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors.
- Trial name
- NCT04012632
- Testing
- this study was an observational study and no interventions were given to the participants
- Volunteers
- 628 people, healthy volunteers welcome
- Sponsor
- Shenzhen Center for Disease Control and Prevention
Pain
Genetic Basis For Variation In NSAID Analgesia In A Clinical Model Of Acute Pain
This study will evaluate how genetic makeup contributes to the variation in people regarding their sensitivity to and experience of pain.
- Trial name
- NCT00115752
- Testing
- Valdecoxib, COX Inhibitor
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Children, Chronic Renal Failure
Effect of Strict Blood Pressure Control and ACE-Inhibition on Progression of Chronic Renal Failure in Pediatric Patients
In children with chronic kidney disease, progression to end-stage renal failure is associated with high patient morbidity and poor quality of life.
- Conditions
- Children, Chronic Renal Failure, Hypertension, Acquired Kidney Disease
- Trial name
- ESCAPE (NCT00221845)
- Testing
- ACE Inhibition, Intensified Blood Pressure Control, Add-on Angiotensin Receptor Blockade
- Where
- 33 sites in Czechia, France and 10 more
- Volunteers
- 400 people
- Sponsor
- Heidelberg University
Blastocystis Infections
Molecular Characterization of Blastocystis Isolates From Human by Restriction Fragment Length Polymorphism (RFLP) Analysis
Blastocystis is an anaerobic unicellular protozoal parasite infecting the gastrointestinal tract of humans and a wide range of animals.
- Trial name
- NCT05580393
- Testing
- RFLP analysis of SSU rRNA
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Attention Deficit Hyperactivity Disorder
Methylphenidate Treatment Response Study of Genetic Polymorphism in Attention Deficit Hyperactivity Disorder(ADHD)
The purpose of this study is to determine whether norepinephrine gene polymorphism affect to treatment response in ADHD
- Trial name
- NCT00862108
- Testing
- Methylphenidate
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Seoul National University Hospital
Age-related Hearing Loss, Presbycusis
Genetic Study of Age Related Hearing Loss
Age-related hearing loss, or presbyacusis, is one of the most common chronically handicapped conditions for the elderly. Many factors including genetics, diet, diseases, drugs, socioeconomic factors and environmental variables…
- Trial name
- ARHL (NCT01732289)
- Testing
- genes
- Where
- Taiwan
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
ITP - Immune Thrombocytopenia
"Cytotoxic T Lymphocyte-Associated Antigen-4 (CTLA-4) Gene Single-nucleotide Polymorphism in Primary Immune Thrombocytopenic Purpura in Children"
the investigators aim in this study to investigate the potential association of single gene polymorphisms of CTLA-4 (SNPs; rs: 3087243) using real-time PCR in children with primary ITP.
- Trial name
- ITP (NCT07014904)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Neonatal Respiratory Distress Syndrome
Association of SCNN1A Single Nucleotide Polymorphisms With Neonatal Respiratory Distress Syndrome
Lung fluid absorption disorders are largely mediated by transepithelial Na+ reabsorption through alpha epithelial sodium channels (α-ENaCs) in alveolar epithelial cells.
- Trial name
- NCT02333669
- Testing
- no intervention
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Asthma
A Cohort Study of Smoking Prevention and Health Promotion for Middle School Students in Wuhan, China
We propose to add a collection of buccal cells to a school-based cohort of 7th graders in Wuhan, a large industrial city in China.
- Trial name
- NCT00341653
- Where
- China
- Volunteers
- 5,051 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
H. Pylori Infection
TLR 9 (rs352140) Gene Polymorphism in Helicobacter Pylori Infection
study aimed to identify the role of TLR9 (rs352140) gene in suppressing or promoting the inflammation related to H. pylori infection in children.This cross-sectional study was conducted on 50 children with positive H.
- Trial name
- NCT07289451
- Testing
- TLR TLR 9 (rs352140) gene polymorphism
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Kidney Diseases
Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA). 2.
- Trial name
- NCT01503645
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Retinopathy of Prematurity, Genetic Polymorphism
Genetic Polymorphism and Retinopathy of Prematurity: Correlation of Clinical Presentations and Severity
Study Aim and Goals 1. Evaluate the correlation between genetic polymorphism and ROP development 2. To study the possibility if there are any specific genetic polymorphisms that lead to poor outcome or recurrence of ROP after…
- Trial name
- NCT05132257
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Neonatal Seizure
Effect of CYP2C9/CYP2C19 Polymorphism on Pharmacokinetics of Phenobarbital in Korean Neonatal Seizure Patients.
The pharmacogenomic profiles of drug metabolizing enzymes play an important role in pharmacokinetics (PK) of drugs. Phenobarbital (PB), worldwidely used for neonatal seizure, is a drug that requires careful dose adjustments based…
- Trial name
- NCT01224457
- Testing
- Phenobarbital
- Volunteers
- 52 people
- Sponsor
- Yonsei University