Clinical trials: Gene Polymorphism
Coronary Arteriosclerosis, Cardiovascular Diseases
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis
To further define the linkage of the Apo A-I gene polymorphism to genetic high density lipoprotein (HDL) deficiency and premature coronary artery disease.
- Conditions
- Coronary Arteriosclerosis, Cardiovascular Diseases, Heart Diseases, Atherosclerosis
- Trial name
- NCT00005183
- Sponsor
- Tufts University
COVID-19 Respiratory Infection
Gene Polymorphism of IL17 and IL 23
rates are in such considerable amount among large population base. The pathogenesis of COVID-19 implicates a potent inflammatory response, involving a complex group of mediators including interleukins.
- Trial name
- COVID 19IL17 (NCT04948515)
- Testing
- laboratory test
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
HIV
Preference of Genetic Polymorphism and Pharmacokinetics
Genetic polymorphism affects plasma concentration of antiretroviral therapy in HIV patients. The investigators investigate the prevalence of genetic polymorphism affecting efavirenz metabolism and the corresponding…
- Trial name
- NCT01658371
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Hepatitis C, Liver Disease
Genetics of Hepatitis C Virus Infection
The diverse clinical syndromes associated with hepatitis C underscore the multifactorial and polygenic nature of HCV infection. Both viral and host factors likely contribute to variations in infection outcome, disease…
- Trial name
- NCT00005657
- Where
- United States
- Volunteers
- 870 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Aortic Dissection
The Relationship Between ALDH2 and Aortic Dissection
The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
- Trial name
- RALAD (NCT02630212)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Qilu Hospital of Shandong University
Disorders of Sex Development, Congenital Adrenal Hyperplasia
Gene Polymorphisms Influencing Steroid Synthesis and Action
The extend of steroid biosynthesis and action is mainly dependent on underlying genetic polymorphisms and gene mutations. These sequence variations in multiple genes involved in steroid biosynthesis and action cause different…
- Conditions
- Disorders of Sex Development, Congenital Adrenal Hyperplasia, Congenital Adrenal Hypoplasia, Adrenal Insufficiency
- Trial name
- NCT00485186
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Bronchiolitis
Genetic Influences of Albuterol Response In Children With Bronchiolitis
Bronchiolitis is a significant cause of morbidity and hospitalization in children, accounting for approximately 125,000 hospitalizations per year in the U.S.
- Trial name
- NCT00570297
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Connecticut Children's Medical Center
Hepatitis B, Hepatocellular Carcinoma
Genetic Polymorphisms of Interleukin-1B and TNF-A and HBV-Related Hepatocellular Carcinoma
By detecting polymorphisms of IL-1β and TNF-α,this study aims to find the effects of cytokine gene polymorphisms(and their interaction) on susceptibility and severity of HBV-related HCC.
- Conditions
- Hepatitis B, Hepatocellular Carcinoma, Chronic Liver Disease
- Trial name
- NCT00629486
- Testing
- Polymorphism of IL-1 beta and TNF-alpha
- Where
- 2 sites in Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Stuttering
Genetic Factors Related to Stuttering
Stuttering is an abnormality in speech that affects the rhythm of speech. People who stutter know what they wish to say, but at the time are unable to say it because of involuntary repetition, unnecessary lengthening…
- Trial name
- NCT00001602
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Invasive Fungal Infection
Voriconazole Trough Plasma Levels : Genetic Polymorphism, Efficacy, Safety in Patients With Hematologic Malignancy
Multiple factors are associated with a large variability in voriconazole exposure following standard dose administration, such as non-linear saturable pharmacokinetics, drug-drug interactions, liver disease, patient age, and…
- Trial name
- NCT01148160
- Testing
- voriconazole
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Asan Medical Center
Childhood Cancer, Genetic Predisposition
Genetic Risks for Childhood Cancer Complications in Switzerland
The objectives of the GECCOS project are to identify genetic variants associated with complications of childhood cancer using genotype-phenotype association studies.
- Conditions
- Childhood Cancer, Genetic Predisposition, Late Effect
- Trial name
- GECCOS (NCT04702321)
- Testing
- Procedure: Biospecimen Collection, Procedure: Medical Chart Review
- Where
- Switzerland
- Volunteers
- 6,000 people
- Sponsor
- University Hospital, Geneva
Polymorphism, Restriction Fragment Length
Relationship Between the VEGF Gene Polymorphism and Cardiometabolic Risk Factors
The aim of the study is to determine the relationship between VEGF gene expression, VEGF gene polymorphism and serum leptin concentration in the Polish population in people with excessive body weight.
- Trial name
- 27/MN/2018 (NCT04077554)
- Testing
- gene expression
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Poznan University of Medical Sciences
PML, AIDS
Genetics of Progressive Multifocal Leukoencephalopathy and Acquired Immunodeficiency Syndrome
This study will identify genetic factors associated with the development of progressive multifocal leukoencephalopathy (PML) in patients with acquired immunodeficiency syndrome (AIDS).
- Trial name
- NCT00342602
- Where
- 6 sites in United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Type 1 Diabetes Mellitus
The Role of FTO Gene Polymorphism and Insulin Preparation in Obesity in Children With Type 1 Diabetes Mellitus
The project aims at assessment of the effect of the FTO gene polymorphism and the type of treatment on the development of overweight/obesity and features of metabolic syndrome in children with type 1 diabetes.
- Trial name
- FTO_T1DM (NCT01279161)
- Where
- 6 sites in Poland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Sick Sinus Syndrome
The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system.
- Trial name
- NCT01310920
- Testing
- observation
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Bronchopulmonary Dysplasia
Genetic Susceptibility for Bronchopulmonary Dysplasia in Preterm Infants
Despite considerable obstetric and neonatal advances in the care of very low birth weight (VLBW) neonates, bronchopulmonary dysplasia (BPD) continues to occur among 20 to 40% of surviving infants, and new ways for combatting this…
- Trial name
- GENBPD (NCT00904774)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Crohn Disease, Pediatric Crohns Disease
Autophagy in Paediatric Crohn's Disease
Crohn's disease is a multifactorial complex disease resulting in a between microbiota and immune system. Indeed, GWAS (Genome-Wide Association Studies) association study pinpointed polymorphisms as genes susceptibility on more…
- Trial name
- P-IBDphagy (NCT05842564)
- Testing
- Blood samples, Biopsies
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Infections
The Role of Genetic Polymorphisms in Innate Immune Response Genes in Susceptibility to Infections
The purpose of this study is to better understand genetic susceptibility to infections and the interactions of specific genetic polymorphisms of innate immune receptors with microbial and fungal organisms.
- Trial name
- NCT00597090
- Where
- United States
- Volunteers
- 319 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Aggressive Periodontitis
Frequency Of MCP-1 And CCR2 Gene Polymorphisms And Its Effect On Gene Expression In Patients With AgP
The aim of this study is to estimate genetic impact of MCP-1 -2518 and its receptor CCR2 -190 polymorphisms on AgP patients among Turkish individuals and whether MCP-1 genotype effects mRNA levels of Peripheral Blood Mononuclear…
- Trial name
- NCT02817568
- Testing
- Drawing Blood
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Polycystic Ovary Syndrome
71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies.
- Trial name
- 17b-ACO (NCT01372293)
- Testing
- oral contraceptive pill
- Volunteers
- 49 people
- Sponsor
- Federal University of Rio Grande do Sul