Clinical trials: Genitourinary System Neoplasm
Polycystic Ovary Syndrome
Reproductive Endocrinology Oxford Study (RepOx)
This is a prospective observational study that aims to identify the underlying mechanisms of PolyCystic Ovarian Syndrome (PCOS) and associated comorbidities such as subfertility, miscarriage; and pregnancy complications such as…
- Trial name
- RepOx (NCT05177562)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 1,175 people
- Sponsor
- University of Oxford
Ovarian Cancer
A Study of Niraparib in Patients With Ovarian Cancer in Clinical Practice
The main aim of this study is to check for side effects from treatment with niraparib. The study sponsor will not be involved in how the participants are treated but will provide instructions on how the clinics will record what…
- Trial name
- NCT05021562
- Testing
- Niraparib
- Where
- Japan
- Volunteers
- 354 people
- Sponsor
- Takeda
Cancer
Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment
RATIONALE: Caspofungin acetate or amphotericin B liposomal may be effective in preventing or controlling fever and neutropenia caused by chemotherapy, bone marrow transplantation, or peripheral stem cell transplantation.
- Trial name
- NCT00008359
- Testing
- caspofungin acetate, liposomal amphotericin B
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer
Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD)
RATIONALE: Mycophenolate mofetil added to immunosuppressive treatment regimens may be effective in treating newly diagnosed chronic graft-versus-host disease caused by stem cell transplantation.
- Trial name
- NCT00089141
- Testing
- mycophenolate mofetil
- Where
- 16 sites in United States, Canada
- Volunteers
- 151 people
- Sponsor
- Martin, Paul
Amenorrhea, Oligomenorrhea
Treatment of Menstrual Cycle Alterations in Adolescents
the aim of the present study is intended to evaluate how treatment with Myo-Inositol and Dioscorea Villosa can help improve menstrual cycle irregularities in adolescents, both with and without PCOS.
- Conditions
- Amenorrhea, Oligomenorrhea, PCOS (Polycystic Ovary Syndrome)
- Trial name
- HP-phD_Adolesc (NCT06800170)
- Testing
- myo-Inositol plus DIoscorea Villosa
- Where
- 2 sites in Georgia, Russia
- Volunteers
- 41 people
- Sponsor
- Lo.Li.Pharma s.r.l
Denys-Drash Syndrome
Denys-Drash Syndrome and Risk of Post-transplant Lymphoproliferative Disorder
Denys-Drash syndrome is a rare genetic disorder of childhood characterized by nephrotic syndrome, nephroblastomas, and genital developmental abnormalities.
- Trial name
- DRASH-PTLD (NCT07605884)
- Testing
- Collection of data from the patient's medical file
- Where
- 7 sites in France
- Volunteers
- 108 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Benign Breast Disease
Evaluating Scaleup of an Adapted Breast Cancer Early Diagnosis Program in Rwanda
Breast cancer incidence is increasing in low- and middle-income countries (LMICs) and breast cancer mortality is high in these regions largely due to late stage diagnoses.
- Conditions
- Breast Cancer, Benign Breast Disease, Cervix Cancer
- Trial name
- NCT05364138
- Where
- Rwanda
- Volunteers
- 2,357 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
HIV Infections, Men
Improving HIV Testing, Linkage, and Retention in Care for Men Through U=U Messaging
This study will evaluate the impact of U=U messaging and counseling on gaps in the HIV care cascade for men, including testing uptake and ART initiation (Aim 1), achieving viral suppression and retention in care (Aim 2) in two…
- Conditions
- HIV Infections, Men, Treatment Adherence
- Trial name
- NCT05602376
- Testing
- U=U testing messaging scripts, U=U adherence messaging scripts
- Where
- 2 sites in South Africa
- Volunteers
- 3,642 people, healthy volunteers welcome
- Sponsor
- Desmond Tutu HIV Foundation
Ovarian Cancer
Role of Laparoscopy in Assessing Resectability of Ovarian Cancer
Aim of Work is Prevention of unnecessary laparotomies and failed attempts to perform optimal cytoreduction in women with advanced ovarian cancer.
- Trial name
- NCT05564234
- Testing
- laparoscopy then primary cytoreductive surgery, laparoscopy then neoadjuvant chemotherapy followed by interval cytoreductive surgery
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Carcinoma, Endometrioid, Fertility Preservation
Fertility Sparing Therapy for Patients With Stage IA G2 Endometrial Cancer
Endometrial cancer (EC) is a prevalent gynecological cancer with an escalating global incidence and a decreasing age of onset. In the era of precision medicine, there is an increasing emphasis on tailoring treatments to different…
- Trial name
- NCT06468215
- Testing
- Treatment Option 1 is a single-drug regimen, with oral medroxyprogesterone acetate (MPA) 500mg/d or MA 320mg/d.
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Peking University People's Hospital
Polycystic Ovary Syndrome, Hyperandrogenism
Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone
During childhood, the levels of certain hormones: gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone are very low.
- Conditions
- Polycystic Ovary Syndrome, Hyperandrogenism, Normal Puberty
- Trial name
- NCT01428089
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Endometrial Cancer, Ovarian Cancer
Tumor Grade Determines PD-1/PDL-1 Expression
Endometrial carcinoma is the most common gynecologic cancer in the western world. Two types are usually described. Type I is the endometrioid and is usually estrogen dependent.
- Trial name
- NCT04528940
- Testing
- PD-1/PDL-1 staining
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- RWJ Barnabas Health at Jersey City Medical Center
Ovarian Cancer, Endometrial Cancer
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Germ Cell Tumor, Testicular Germ Cell Tumor
- Trial name
- NCT06276491
- Testing
- XmAb541
- Where
- 27 sites in United States, Belgium and 4 more
- Volunteers
- 282 people
- Sponsor
- Xencor, Inc.
Neuroblastoma, Rhabdomyosarcoma
Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors
Hematopoietic stem cell transplantation can cure patients with blood cancer and other underlying diseases. αβ-T cell and B cell depletion has been introduced to decrease GVHD and PTLD and has demonstrated effectiveness for…
- Conditions
- Neuroblastoma, Rhabdomyosarcoma, Synovial Sarcoma, Peripheral Nerve Sheath Tumors
- Trial name
- NCT06625190
- Testing
- Miltenyi CliniMACS Prodigy ® system, Zoledronic acid
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Florida
Ovarian Cancer
Transforming Ovarian Cancer Diagnostic Pathways
The goal of this observational cohort study is to compare the diagnostic accuracy and cost effectiveness of Risk of Malignancy Algorithm (ROMA) compared with CA125 in the diagnosis of ovarian cancer in patients attending their…
- Trial name
- SONATA (NCT06129968)
- Where
- 3 sites in United Kingdom
- Volunteers
- 34,000 people
- Sponsor
- Professor Sudha Sundar
Ovarian Cancer
Combination Chemotherapy With or Without Surgery in Treating Patients With Stage III Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or combining chemotherapy with surgery may kill more tumor cells.
- Trial name
- NCT00002568
- Testing
- cisplatin, paclitaxel, conventional surgery
- Where
- 55 sites in United States
- Volunteers
- 470 people
- Sponsor
- Gynecologic Oncology Group
Atherosclerosis, Cardiovascular Diseases
Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome
To investigate whether women with Polycystic Ovary syndrome (PCOS) have evidence of an increased prevalence rate of subclinical atherosclerosis as measured by the presence of plaque, increased intima-medial carotid artery wall…
- Conditions
- Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Carotid Artery Diseases
- Trial name
- NCT00005459
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Polycystic Ovary Syndrome
Metabolic Disorders in Polycystic Ovarian Syndrome
The purpose of this study is to elucidate the significance of adipocytokine in women with PCOS among adiposity, hyperandrogenism and insulin resistance.
- Trial name
- NCT00172523
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Neoplasms
Treatment Protocol of Voraxaze for Patients Experiencing or at Risk of Methotrexate Toxicity
This protocol is for the treatment of toxic plasma methotrexate concentrations (>1 micromole per liter) in patients with delayed methotrexate clearance due to impaired renal function
- Trial name
- NCT00481559
- Testing
- Voraxaze (glucarpidase)
- Sponsor
- BTG International Inc.
Periodontitis, Polycystic Ovary Syndrome
Evaluation of Periodontal Status and hsCRP Levels in Females With PCOS on CPA/EE Combination Drug Regimen
PCOS is a widely reported condition among young female population and anti-androgen agents are increasingly being used as part of the medical management of such cases.
- Conditions
- Periodontitis, Polycystic Ovary Syndrome, Gingivitis
- Trial name
- NCT05021861
- Testing
- Cyproterone Acetate, Ethinyl Estradiol Drug Combination, FEMALE PATIENTS WITH PCOS, Control group
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak