Clinical trials: Glaucoma Therapy
Primary Congenital Glaucoma, Pediatric Glaucoma
Subscleral Trabeculectomy With Inverted T-Shaped Deep Sclerectomy for Primary Congenital Glaucoma
Primary congenital glaucoma (PCG) is a vision-threatening disorder of childhood characterized by elevated intraocular pressure (IOP) resulting from developmental abnormalities of the anterior chamber angle.
- Conditions
- Primary Congenital Glaucoma, Pediatric Glaucoma, Intraocular Pressure
- Trial name
- TDS-PCG (NCT07701278)
- Testing
- Subscleral Trabeculectomy Combined With Inverted T-Shaped Deep Sclerectomy
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Benha University
Open-angle Glaucoma (OAG), Ocular Hypertension (OHT)
Qlaris Study of QLS-111 in Combination With a PGA for OAG and/or OHT Patients
Qlaris Phase 2 clinical study investigating the safety, tolerability, and ocular hypotensive efficacy of QLS-111 in combination with latanoprost in open-angle glaucoma (OAG) and/or ocular hypertension (OHT) patients.
- Conditions
- Open-angle Glaucoma (OAG), Ocular Hypertension (OHT), Glaucoma
- Trial name
- NCT06249152
- Testing
- QLS-111, 0.015%, QLS-111, 0.030%, QLS-111, 0.075%
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Qlaris Bio, Inc.
Pediatric Aphakic Glaucoma
Trabeculectomy With MMC Versus Ahmed Glaucoma Implant for Treatment of Pediatric Aphakic Glaucoma
In this randomized clinical trial we compare trabeculectomy with mitomycin-C (T+MMC) and Ahmed glaucoma implant (AGI) in treatment of aphakic glaucoma in children under 16 years of age.Complete and qualified success were defined…
- Trial name
- NCT00371072
- Testing
- trabeculectomy with mitomycin-C
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Glaucoma, Congenital, Surgical Treatment
Inverted T Trabeculectomy Primary Congenital Glaucoma
This study aims to evaluate the safety and efficacy of novel Inverted T trabeculectomy in Primary Congenital Glaucoma (PCG). It enrolled 50 eyes of 25 children with PCG.
- Trial name
- Inverte T trab (NCT06837610)
- Testing
- Inverted T trabeculectomy
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Benha University
Glaucoma; Drugs
Evaluation of Adherence to Clinical Treatment of Glaucoma
Evaluation of adherence to clinical treatment of glaucoma in patients of a Reference Ophthalmological Hospital in Goiânia using Morisky Adhesion scale as a validated questionary.
- Trial name
- NCT03338088
- Where
- 2 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto de Olhos de Goiania
Glaucoma, Glaucoma, Open-Angle
Dresden Glaucoma and Treatment Study (DGTS)
To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma, Angle-Closure, Glaucoma, Low Tension
- Trial name
- NCT02959242
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Technische Universität Dresden
Primary Congenital Glaucoma, Developmental Glaucoma
Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas
Newborn and children can be affected by two subgroups of this disease: (1) primary congenital glaucoma (PCG) or (2) developmental glaucoma (DG).
- Trial name
- STOP-Glaucoma (NCT04647929)
- Testing
- Santen PRESERFLO MicroShunt, Trabeculectomy
- Sponsor
- University of Zurich
Growth Hormone Treatment, Glaucoma
Is Recombinant Growth Hormone Therapy Associated With Increased Intraoccular Pressure?
Recombinant growth hormone is a common therapy in the pediatric population. A number of associated side effects have been described.
- Trial name
- NCT00867971
- Testing
- Measuring intraoccular pressure
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Assaf-Harofeh Medical Center
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Eye Diseases
Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases
This study will evaluate and treat children or adults with inherited or developmental eye conditions. It will allow specialists in pediatric ophthalmology, genetic ophthalmology, and ocular motility at the National Eye Institute…
- Trial name
- NCT00076271
- Where
- 2 sites in United States
- Volunteers
- 350 people
- Sponsor
- National Eye Institute (NEI)
Glaucoma, Open-Angle, Ocular Hypertension
A Study Comparing IOP-Lowering Treatments to Bimatoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
An observational study comparing changing from an IOP-lowering treatment to a bimatoprost-containing IOP treatment in primary open-angle glaucoma (POAG) or ocular hypertension (OHT).
- Trial name
- NCT01646151
- Testing
- Bimatoprost
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 2,580 people
- Sponsor
- Allergan
Congenital Glaucoma
Non-penetrating Deep Sclerectomy Versus Trabeculotomy- Trabeculectomy Operation in Treatment of Primary Congenital Glaucoma
The high success rate of the non-penetrating deep sclerectomy (NPDS) procedure in adult glaucomatous patients motivated some glaucoma specialists to try it as an alternative procedure in childhood PCG.
- Trial name
- NCT06189326
- Testing
- non-penetrating deep sclerectomy, primary combined trabeculotomy-trabeculectomy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Al-Azhar University
Glaucoma, Ocular Hypertension
Long-Term Non-Interventional Latanoprost Study
This is a non-interventional, prospective, longitudinal cohort study. A total of 150 pediatric subjects with glaucoma or elevated intraocular pressure, including 75 latanoprost-treated subjects and 75 non-topical prostaglandin…
- Trial name
- LYNX (NCT01265719)
- Testing
- No intervention other than routine medical care
- Where
- 29 sites in Belgium, Colombia and 12 more
- Volunteers
- 175 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.