Clinical trials: Glucose Response
Diabetes Mellitus, Type 1
Investigation of Otelixizumab in New-Onset, Autoimmune Type 1 Diabetes Mellitus Patients
The aim of this Phase I/IIa study is to identify a safe and tolerable dosage regimen of intravenously administered otelixizumab.
- Trial name
- NCT02000817
- Testing
- Otelixizumab
- Where
- 6 sites in Belgium
- Volunteers
- 30 people
- Sponsor
- GlaxoSmithKline
Inflammatory Responses, Muscle Fatigue
Effectiveness of Chocolate Milk in Recovery Among Highly Trained Kayakers: A Metabolic and Inflammatory Perspectives
Kayaking requires high energy expenditure and optimal metabolic adaptation for performance and recovery. While research on other sports exists, the effects of chocolate milk on kayakers' recovery remain unexplored.
- Conditions
- Inflammatory Responses, Muscle Fatigue, Recovery Time, Hunger
- Trial name
- Kayakers2025 (NCT06935058)
- Testing
- Chocolade milk
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Severe Hypoglycemia, Type1diabetes
Longitudinal Study of the GLUcagon REsponse to Hypoglycemia in Children and Adolescents With New-onset Type 1 DIAbetes
The GLUREDIA study investigates the counter-regulatory response (CRR) during hypoglycemia in children with type 1 diabetes (T1D).
- Trial name
- GLUREDIA (NCT06770621)
- Testing
- Insulin-induced hypoglycemia test, Glucagon profile, Biological sample once
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Type 2 Diabetes Mellitus, Postprandial Hyperglycemia
Effects of Insulin Treatment on Postprandial Platelet Activation in Patients With Non-insulin-dependent Diabetes Mellitus (NIDDM)
The postprandial phase in diabetic patients is characterized by a rapid increase in blood glucose levels, increase in platelet aggregation, LDL oxidation and over production of thrombin.
- Trial name
- NCT00771693
- Testing
- Insulin aspart (Novorapid®)
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
SARS-CoV2 Infection Common Pathogens, Diabetes Mellitus, Type 1
Characterisation of the Immune Response to SARS-CoV-2 Infection / COVID-19 in Type 1 Diabetes
Emerging clinical details of the current SARS-CoV-2 pandemic have illustrated that there are multiple clinical presentations and outcomes of this viral infection.
- Trial name
- TIRID (NCT05171998)
- Testing
- venous blood sample
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Liver Fat, Type 2 Diabetes
EXIT: Prospective Study of the Response to Exercise
Background : Regular exercise is a cornerstone in the prevention and the management of comorbidities. Unfortunately, the metabolic benefit of exercise training is not universal and varies among individuals.
- Trial name
- EXIT (NCT02204670)
- Testing
- Acute release of irisin after a single exercise session.
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type 1 Diabetes
Early Markers of Disease and Response to Therapy
The purpose of this study is to identify early immune markers associated with response to treatment with abatacept in individuals with Type 1 diabetes (T1D).
- Trial name
- NCT04118153
- Testing
- Abatacept
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sandra Lord, MD
Diabetes Mellitus, Type 1
The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1)
The Diabetes Prevention Trial of Type 1 (DPT-1) was a multicenter randomized, controlled clinical trial designed to determine whether it is possible to delay or prevent the clinical onset of type 1 diabetes through daily doses of…
- Trial name
- DPT-1 (NCT00004984)
- Testing
- Parenteral Insulin, Close Observation, Oral Insulin
- Where
- 15 sites in United States, Canada
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Small for Gestational Age
Effect of Insulin Sensitization on IGF-1 Response to Growth Hormone in SGA Children
This study is aimed to determine if Metformin treatment in children born small for gestational age (SGA) who are being treated with Growth Hormone (GH) for short stature improves the response to GH by producing greater…
- Trial name
- NCT02931591
- Testing
- Metformin, Growth Hormone
- Volunteers
- 24 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Obesity, Childhood, Asthma in Children
Asthma and Obesity Diet Versus Exercise
Obesity is recognized as a pro-inflammatory condition associated with multiple chronic diseases, including asthma. The specific mechanisms linking asthma and obesity remain hypothetical.
- Conditions
- Obesity, Childhood, Asthma in Children, Inflammatory Response, Metabolic Syndrome
- Trial name
- NCT03644355
- Testing
- Lifestyle counseling
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Type 2 Diabetes Mellitus
Lipid, Glycemic, and Insulin Responses to Meals Rich in Different Fatty Acids
A meal rich in very-long chain omega-3 fatty acids or oleic acid may lower postprandial insulin levels in comparison to a meal rich in linoleic acid or palmitic acid.
- Trial name
- NCT00479791
- Testing
- Test meals rich in different fatty acids
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes Mellitus
Closed-loop Response to Unannounced Mixed and Carbohydrates-rich Breakfasts
The development of advanced hybrid closed-loop (a-HCL) systems represents a significant step toward in improving glucose control and reducing user-dependent variability, especially In pediatric patients.
- Trial name
- CRUMB (NCT07455643)
- Testing
- Unannounced meal
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Catania
Severe Sepsis, Septic Shock
Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock
The purpose of this study is to determine the effect of the intensive insulin therapy on coagulation and fibrinolysis in patients affected by severe sepsis and septic shock.
- Trial name
- NCT00159952
- Testing
- intensive insulin therapy
- Where
- 3 sites in Italy
- Volunteers
- 90 people
- Sponsor
- Policlinico Hospital
Metabolic Syndrome
Is There Effect of Adding Honey Intake to Free Walking in Metabolic Syndrome Children
Metabolic Syndrome is common in Children and complementary therapies are important in its treatment such exercise and functional food intake including honey.
- Trial name
- NCT06466317
- Testing
- Honey intake with walking exercise, Walking exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ahram Canadian University
Pain, Infant, Newborn
Using Sugar Water to Relieve Pain in Infants
This study will examine the safety and effectiveness of sugar water to relieve pain in newborn infants during painful blood tests and injections.
- Conditions
- Pain, Infant, Newborn, Diabetes
- Trial name
- NCT00213213
- Testing
- Sucrose
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- The Hospital for Sick Children
Diabetes Mellitus
Sulfonylurea Response in Patients With Diabetes Due to Kir6.2 Mutations
The purpose of this study is to investigate whether patients with diabetes due to Kir6.2 mutations can be treated with sulfonylurea medication rather than insulin, and if this is the case to investigate the mechanism for…
- Trial name
- NCT00334711
- Testing
- Sulfonylurea
- Volunteers
- 50 people
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
type1diabetes
Response to BNT162b2 Vaccine in Adolescents With Type 1 Diabetes
Adolescents with type 1 diabetes may be at increased risk for severe coronavirus disease-2019 (COVID-19) and are therefore prioritized for access to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination.
- Trial name
- NCT05620251
- Testing
- Blood test
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Infant Development, Glucose, High Blood
Effect of Nutritional Intervention on Metabolic Response in Infants
The purpose of this study is to determine the glucose response of complementary feeding regimens consisting of two different follow-up formulas (FUFs) and infant cereals (ICs).
- Trial name
- NCT04483453
- Testing
- EXPL feeding regimen, CTRL feeding regimen
- Where
- Philippines
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Permanent Neonatal Diabetes Mellitus
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)
The purpose of this study is to investigate long term response of sulfonylurea and glucose control in children with diabetes due to mutations in ABCC8 that have been switched from insulin injections to sulfonylurea tablets.
- Trial name
- SuResponsSUR (NCT02624830)
- Testing
- Sulfonylurea
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Haukeland University Hospital