Clinical trials: Gut Function
Colonic Cancer, Postoperative Care
Rehabilitation Following Laparoscopic Colonic Surgery
The standard procedure for treating colonic cancer is changing from open surgery to laparoscopic surgery. Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the…
- Conditions
- Colonic Cancer, Postoperative Care, Fatigue
- Trial name
- NCT00938210
- Testing
- Laparoscopic colonic surgery
- Where
- 2 sites in Denmark
- Volunteers
- 50 people
- Sponsor
- Aarhus University Hospital
Self-hypnosis, Functional Bowel Disorder
Hypnotherapy With Audiofiles for Children and Adolescents With Disorders of Gut-brain Interactions in Sweden -a Feasibility Study
This study aims at testing the effect and feasibility of a new treatment strategy - hypnotherapy mediated with audio files - for children and adolescents with disorders of gut-brain-interaction (DGBI) in Sweden.
- Conditions
- Self-hypnosis, Functional Bowel Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT06493097
- Testing
- Gut-directed hypnotherapy via audio files
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Fontan Physiology Patients With PB or PLE, Fontan Physiology Patients Without PB or PLE
Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology
The investigators are studying what causes Plastic Bronchitis and Protein Losing Enteropathy. The investigators think that these problems are from too much of two small proteins called Vasoactive Intestinal Peptide (VIP) and…
- Trial name
- NCT01563757
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease
Exercise Training in Youth With Inflammatory Bowel Disease
Children and adolescents with inflammatory bowel disease (IBD) suffer from many extra-intestinal side effects, including impaired muscle strength, low aerobic fitness, low bone density, and chronic inflammation.
- Conditions
- Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease, Pediatric Ulcerative Colitis
- Trial name
- NCT05591976
- Testing
- Exercise training program
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- McMaster University
Infectious Gastroenteritis
Probiotics for Infectious Diarrhea in Children in South India
The overall goal of this study is to investigate whether the modulatory effects of probiotics, which are used as food supplements (Lactobacillus GG marketed as Culturelle or yoghurt) in the gastrointestinal tract promote…
- Trial name
- NCT01130792
- Testing
- Lactobacillus GG, Inulin
- Where
- India
- Volunteers
- 124 people
- Sponsor
- Christian Medical College, Vellore, India
Clinical Efficacy, Treatment Efficacy
Lubiprostone for Functional Constipation in the Under 18 Years Patients
The investigators will enroll subjects 8 - < 18 years of age, fulfilling Rome IV criteria for functional constipation. Participants will be randomly assigned to either Lubiprostone treatment (study group), or the control group…
- Conditions
- Clinical Efficacy, Treatment Efficacy, Drug Side Effect
- Trial name
- NCT05144295
- Testing
- Lubiprostone Pill, Lactulose Oral Liquid Product, Bisacodyl 5 MG
- Where
- 2 sites in Egypt
- Volunteers
- 274 people
- Sponsor
- Alexandria University
Functional Nausea
Comparison of the Therapeutic Effect of Acupressure Therapy and Iberogast ® (STW-5) in Children With Functional Nausea
Functional gastrointestinal disorders are common disorders that are characterized by persistent and recurring GI symptoms. These occur as a result of abnormal functioning of the GI tract and are not caused by structural or…
- Trial name
- NCT02660970
- Testing
- Acupressure, Iberogast
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Irritable Bowel Syndrome With Constipation
A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation
The purpose of this study is to evaluate the safety and efficacy of linaclotide for the treatment of Irritable Bowel syndrome with Constipation (IBS-C), in children age 7-17 years.
- Trial name
- LIN-MD-63 (NCT02559817)
- Testing
- Linaclotide Dose A, Linaclotide Dose B, Linaclotide Dose C
- Where
- 48 sites in United States, Canada
- Volunteers
- 101 people
- Sponsor
- Forest Laboratories
Irritable Bowel Syndrome
Effect of Doxepin and Nortriptyline on Irritable Bowel Syndrome
The objective of this randomized triple blind controlled trial is to compare the effects of Doxepin and Nortriptyline on diarrhea predominant irritable bowel syndrome.
- Trial name
- NCT01268709
- Testing
- Doxepin, Nortriptyline
- Where
- Iran
- Sponsor
- Qom University of Medical Sciences
Cardiometabolic Risk, Executive Function
Effects of Diet and Exercise Interventions on Cardiometabolic Risk Markers, Executive Function, and Intestinal Flora
The purpose of this study is to estimate the effects of diet and exercise interventions on body weight, cardiovascular metabolic markers, executive function, and intestinal flora among undergraduate students, as well as the…
- Conditions
- Cardiometabolic Risk, Executive Function, Intestinal Microbiome
- Trial name
- NCT04834687
- Testing
- Exercise, Diet
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
VICO-trial: Video Consultations in the Follow-up of Children With Functional Abdominal Pain Disorders
The goal of this non-inferiority randomized controlled multi-center trial is to investigate the use of video consultations in the follow-up care of children aged 4 - 18 years old with functional abdominal pain disorders (FAPDs).
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Abdominal Migraine
- Trial name
- VICO (NCT06665867)
- Testing
- Video consultation, Face-to-face consultation
- Where
- Netherlands
- Volunteers
- 208 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Bladder Cancer
The Impact of Intrathecal Morphine Versus Continuous Epidural Analgesia on Return of Bowel Function in Patients Undergoing Laparoscopic Ileal Conduit
This study aims to compare the effects of intrathecal morphine (ITM) and continuous epidural analgesia (CEA) on bowel function recovery after Bricker surgery.This study was a prospective, randomized controlled trial that included…
- Trial name
- NCT06688643
- Testing
- ITM group, EA group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xiaguang Duan
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Functional Constipation in Children
Effect of Probiotic on Gut Microbiota in Young Children With Functional Constipation
This study was a 28-day, open-label, randomized controlled trial involving infants and toddlers diagnosed with functional constipation. Participants were randomized to receive either Bifidobacterium longum subsp.
- Trial name
- NCT07360535
- Testing
- Probiotic, Lactulose Oral Liquid Product, probiotic + lactulose
- Where
- 2 sites in China, Malaysia
- Volunteers
- 84 people
- Sponsor
- Min-Tze LIONG
Thyroid Disease, Irritable Bowel Disease
Study of Thyroid Status in Patients With IBD
. The aim of the present study is to study thyroid state in patients with IBD
- Trial name
- NCT05542368
- Testing
- Thyroid tests
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Enteral Feeding Intolerance
Effect of Blenderized Enteral Tube Feeds on Pediatric Upper Gastrointestinal Tract Physiology
Blenderized diets consist of a wide range of table foods such as fruits, vegetables, meat and legumes, pureed in a blender and administered via gastrostomy tube.
- Trial name
- NCT04900597
- Testing
- Elecare Jr, Nourish, Real Foods Blends
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Boston Children's Hospital
Diarrhea-predominant Irritable Bowel Syndrome
Special Drug Use Surveillance of Irribow in Female Patients
The purpose of the survey is to evaluate the safety and efficacy of Irribow and Irribow OD Tablets in post-marketing medical practice and to examine the status of treatment compliance.
- Trial name
- NCT02612649
- Testing
- Ramosetron
- Where
- 34 sites in Japan
- Volunteers
- 793 people
- Sponsor
- Astellas Pharma Inc
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
NPDT Evaluation in Children With CFTR and (PSC)
The investigators hypothesize that PSC in children is associated with mutations and functional changes of the cystic fibrosis (CF) gene.
- Trial name
- NPD (NCT00179439)
- Testing
- nasal potential difference testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Functional Gastrointestinal Disorders (FGID), FGID According to the Rome III Criteria
Cognitive Behavior Therapy (CBT) for Children With Functional Gastrointestinal Disorders
The purpose of the trial is to develop a treatment protocol to be used in trials studying internet-delivered CBT for children with functional gastrointestinal disorders (FGID).
- Conditions
- Functional Gastrointestinal Disorders (FGID), FGID According to the Rome III Criteria, Irritable Bowel Syndrome (IBS), Functional Abdominal Pain
- Trial name
- CBT (NCT02113605)
- Testing
- Cognitive behavior therapy
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Hirschsprung Disease
Urinary and Sexual Symptoms in Patients With Hirschsprung Disease
Hirschsprung disease is a rare congenital disorder affecting the gastrointestinal tract of newborns. It is caused by the absence of enteric ganglion cells in a segment of the large intestine, preventing normal bowel function and…
- Trial name
- UroSexH (NCT07742436)
- Testing
- Type of pull-through procedure performed as part of routine clinical care (Swenson, Duhamel, or Soave).
- Where
- 5 sites in France
- Volunteers
- 556 people
- Sponsor
- University Hospital, Grenoble