Clinical trials: Gut Function
Irritable Bowel Syndrome
Helicobacter Pylori Eradication and Irritable Bowel Syndrome: A Prospective Study
H. Pylori is frequently observed in patients with irritable bowel syndrome(IBS). However, the effect of H. pylori eradication on IBS is not clear.
- Trial name
- NCT04512898
- Testing
- Triple therapy for H.pylori
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rectal Prolapse
Pathologic Assessment of Rectal Prolapse in the Young
Patients aging less than 45 years with rectal prolapse will undergo full pathologic and functional assessment to determine the underlying etiology.
- Trial name
- NCT03012464
- Testing
- Pathologic and functional assessment
- Where
- 2 sites in Egypt
- Volunteers
- 10 people
- Sponsor
- Mansoura University
Irritable Bowel Syndrome
Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children
The primary objectives of this study are to explore the therapeutic effect of eluxadoline in treating irritable bowel syndrome with diarrhea (IBS-D) in pediatric participants 6-17 years of age, to evaluate the pharmacokinetics of…
- Trial name
- NCT03339128
- Testing
- Eluxadoline
- Where
- 46 sites in United States, Bulgaria and 7 more
- Volunteers
- 272 people
- Sponsor
- AbbVie
Health, Children
A Study on the Changes and Prognosis of Intestinal Microbiota and Function in Infants With Food Allergies
Microorganisms maintain a complex interrelationship with the human body, influencing each other. In recent years, people have gradually realized that the formation of the pediatric microecosystem is closely related to the…
- Conditions
- Health, Children, Gut Microbiota
- Trial name
- NCT06854536
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hirschsprung Disease
Urinary and Sexual Symptoms in Patients With Hirschsprung Disease
Hirschsprung disease is a rare congenital disorder affecting the gastrointestinal tract of newborns. It is caused by the absence of enteric ganglion cells in a segment of the large intestine, preventing normal bowel function and…
- Trial name
- UroSexH (NCT07742436)
- Testing
- Type of pull-through procedure performed as part of routine clinical care (Swenson, Duhamel, or Soave).
- Where
- 5 sites in France
- Volunteers
- 556 people
- Sponsor
- University Hospital, Grenoble
Infantile Colic, Gastroesophageal Reflux (GER)
BioAmicus Complete for Functional Gastrointestinal Symptoms in Infants Aged 0 to 24 Months
Infants often experience functional gastrointestinal symptoms (e.g., colic, excessive gas, regurgitation, constipation, or loose stools) that distress families and may reflect an imbalance of the gut microbiome.
- Conditions
- Infantile Colic, Gastroesophageal Reflux (GER), Functional Constipation, Functional Diarrhea
- Trial name
- CTBE2503 (NCT07148583)
- Testing
- BioAmicus Complete, Usual Care (No Probiotic)
- Where
- Vietnam
- Volunteers
- 110 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease
Exercise Training in Youth With Inflammatory Bowel Disease
Children and adolescents with inflammatory bowel disease (IBD) suffer from many extra-intestinal side effects, including impaired muscle strength, low aerobic fitness, low bone density, and chronic inflammation.
- Conditions
- Pediatric Inflammatory Bowel Diseases, Pediatric Crohns Disease, Pediatric Ulcerative Colitis
- Trial name
- NCT05591976
- Testing
- Exercise training program
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- McMaster University
Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC)
Real-World Study on Fecal Microbiota Transplantation: Long-Term Effectiveness and Safety Statistics
This is a large-scale observational study aiming to evaluate the long-term effectiveness and safety of Fecal Microbiota Transplantation (FMT).
- Conditions
- Clostridium Difficile Infection Recurrence, Ulcerative Colitis (UC), Crohn Disease (CD), Irritable Bowel Syndrome (IBS)
- Trial name
- NCT07261826
- Where
- China
- Volunteers
- 4,000 people
- Sponsor
- Chen QiYi
IBS - Irritable Bowel Syndrome
RCT of VR Therapy for IBS
Through a pilot randomized controlled trial (RCT), the aim is to test the clinical impact and feasibility of a virtual reality (VR) cognitive behavioral therapy (CBT) program versus sham VR among patients with irritable bowel…
- Trial name
- NCT06687616
- Testing
- SynerGI
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Christopher Almario
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis), Inflamatory Bowel Disease
Physical Activity and Fitness in Pediatric Inflammatory Bowel Disease
Pediatric inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic condition associated not only with intestinal inflammation but also with reduced physical fitness, fatigue, impaired…
- Trial name
- PAFIT-IBD (NCT07484620)
- Testing
- Physical Activity Intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Infant Growth
Growth and Health Efficacy of Novel Infant Formula : A Randomized Trial
Randomized, controlled study consisting of three parallel arms to investigate the effects of novel infant formula on growth, gut health, immune function, and sleep status in healthy infants and young children aged 12-18 months.
- Trial name
- NCT07534735
- Testing
- Investigational Formula 1, Investigational Formula 2
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Biostime (Changsha) Nutrition Foods Limited
Cerebral Palsy, Congenital
Effects of Hippotherapy in Children With Cerebral Palsy
Cerebral palsy is a group of permanent disorders affecting movement and posture due to non-progressive disturbances in the developing brain.
- Trial name
- NCT07739680
- Testing
- Hippotherapy Program, Special Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fenerbahce University
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
Hypnotherapy Through Self-exercises in Children With Functional Abdominal Pain in Primary Care
The goal of this randomised controlled trial is to study the (cost-)effectiveness of home-based hypnotherapy by self-exercises in children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) in primary care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Functional Abdominal Pain Syndrome
- Trial name
- ZelfHy (NCT05636358)
- Testing
- Home-based hypnotherapy
- Where
- Netherlands
- Volunteers
- 152 people
- Sponsor
- University Medical Center Groningen
Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS)
Pain in Pediatric Patients - Internet Interventions for Disorders of Gut-brain Interaction
Many children and adolescents often experience long-lasting stomach pain. In many cases, this is due to disorders of gut-brain interaction (DGBI), such as irritable bowel syndrome (IBS), functional abdominal pain, and functional…
- Conditions
- Irritable Bowel Disease, Functional Abdominal Pain - Not Otherwise Specified (FAP-NOS), Functional Dyspepsia
- Trial name
- PIPPI (NCT07319078)
- Testing
- Gut-directed hypnotherapy, Cognitive-behavioral therapy
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Karolinska Institutet
Perforated Appendicitis
Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.
- Trial name
- NCT00528138
- Testing
- Laboratory Test
- Where
- Chile
- Volunteers
- 132 people
- Sponsor
- Cirujanos la Serena
Irritable Bowel Syndrome
Effect of Low Fermentable Oligosaccharides, Disaccharides ,Monosaccharides and Polyols (FODMAP) Diet on Control of Pediatric Irritable Bowel Syndrome and Quality of Life
To evaluate the impact of low FODMAP diet on Health related Quality of life in children with Irritable bowel syndrome according to ROME IV criteria in a group of patients in pediatric Hospital at Ain Shams University
- Trial name
- NCT05396651
- Testing
- low fodmap diet, NICE guidelines for IBS
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sarah Abdelrahman El Ezaby
Autism Spectrum Disorder, Functional Gastrointestinal Disorders
Low-FODMAP Diet and Probiotics: Effects on Gut, Behavior, and Microbiota in Children With Autism Spectrum Disorder
The goal of this clinical trial was to evaluate whether a low-FODMAP diet and probiotic supplements could reduce gastrointestinal (GI) symptoms and behavior problems in children with autism spectrum disorder (ASD) who also…
- Trial name
- NCT07086157
- Testing
- Probiotic, Low-FODMAP Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 16 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Hirschsprung Disease, Ganglion
The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those…
- Conditions
- Hirschsprung Disease, Ganglion, Hirschsprung Disease, Long-Segment, Hypoganglionosis
- Trial name
- NCT04149093
- Testing
- Calretinin staining
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Justine's Hospital
Disorder of Stomach Function and Feeding Problems in Newborn, Feeding and Eating Disorders of Childhood
Effect of Early Oral Triple Viable Bifidobacterium Intestinal Flora in Preterm
Gut of newborn preterm is sterile, immediately by the mother and the surrounding environment from microbial colonization. As the effects of diet, intestinal flora is rapidly changed.
- Trial name
- NCT02060084
- Testing
- a control group, a probiotic-supplemented group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wang Hua
Constipation, Constipation Chronic Idiopathic
A Pilot Study to Explore the Role of Gut Flora in Chronic Constipation
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding chronic constipation
- Conditions
- Constipation, Constipation Chronic Idiopathic, Constipation - Functional, Constipation (Excl Faecal Impaction)
- Trial name
- NCT04148248
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome