Clinical trials: HSV-2
HIV
An Assessment of an HIV Prevention Intervention (Project AIM) Among Junior Secondary School Students in Eastern Botswana
The purpose of this study is to examine the effectiveness of an HIV prevention intervention called Project AIM (Adult Identity Mentoring) to delay onset of sexual activity and reduce sexual risk behaviors among students…
- Trial name
- AIM (NCT02455583)
- Testing
- Project AIM (Adult Identity Mentoring)
- Where
- Botswana
- Volunteers
- 4,732 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV
School Support as Structural HIV Prevention for Adolescent Orphans in Kenya
The purpose of this study is to test whether school support can keep adolescent Kenyan orphans in school, reduce sexual risk behaviors, and prevent HIV /HSV-2 infection.
- Trial name
- NCT01501864
- Testing
- School Support Intervention
- Where
- 2 sites in United States, Kenya
- Volunteers
- 835 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
HIV/AIDS, HSV-2 Infection
Cash Transfer to Adolescent Girls and Young Women to Reduce Sexual Risk Behavior - an Impact Evaluation
Vulnerability to HIV infection in Adolescent Girls and Young Women (AGYW) is mainly influenced by structural factors which mediate through sexual risk behavior.
- Trial name
- CARE (NCT03597243)
- Testing
- Cash Transfer
- Where
- Tanzania
- Volunteers
- 3,120 people
- Sponsor
- National Institute for Medical Research, Tanzania
Genital Herpes, HSV-2 Infection
Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection
The main purpose of this clinical study is to see if a maintenance dose of GEN-003 reduces the number of days that subjects have a genital herpes recurrence.
- Trial name
- NCT03146403
- Testing
- GEN-003, Matrix-M2, 0.9% normal saline
- Where
- 8 sites in United States
- Volunteers
- 33 people
- Sponsor
- Genocea Biosciences, Inc.
Herpes Simplex
Herpevac Neonatal Substudy
The purpose of this study to look at the antibodies (proteins from the body's infection fighting system) in the blood of babies delivered by women who are participants in the Herpevac Trial for Women, and who were vaccinated with…
- Trial name
- NCT00138320
- Where
- 5 sites in United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HSV-2 Infection, HIV Infections
Impact Evaluation of a School-Based Sexuality and HIV Prevention Education Activity in South Africa
The purpose of this study is to evaluate the impact of the new South African Department of Basic Education (DBE) sexuality and HIV education program that uses scripted lesson plans and supporting activities and will be…
- Conditions
- HSV-2 Infection, HIV Infections, Pregnancy Related
- Trial name
- NCT04205721
- Testing
- School-based sexuality and HIV prevention scripted lesson plans
- Where
- South Africa
- Volunteers
- 23,061 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
Stepping Stones Program for Preventing HIV Infection in Residents of Rural South African Communities
This study will evaluate the effectiveness of Stepping Stones, an HIV-prevention education program, versus a brief HIV-focused intervention, in improving sexual health and preventing HIV infection in young residents of rural…
- Trial name
- NCT00332878
- Testing
- Stepping Stones, stepping Stones short
- Where
- South Africa
- Volunteers
- 2,801 people, healthy volunteers welcome
- Sponsor
- Medical Research Council, South Africa
HIV Infections, HIV Seronegativity
A Study of Acyclovir to Help Prevent HIV Infection in People With Genital Herpes
Genital herpes (HSV-2) is the most common cause of genital sores worldwide, and the presence of genital sores is a significant risk factor for becoming infected with HIV.
- Conditions
- HIV Infections, HIV Seronegativity, Herpes Genitalis
- Trial name
- NCT00076232
- Testing
- Acyclovir
- Where
- 3 sites in United States
- Volunteers
- 3,682 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS, HSV-2 Infection
The Impact of VCT and Condom Distribution as HIV Prevention Strategies Among Youth in Kenya
The vast majority of new HIV infections occur in sub-Saharan Africa, where nearly 2 million people become infected with HIV/AIDS every year.
- Trial name
- NCT03868644
- Testing
- Voluntary Counseling and Testing for HIV (VCT), Condoms
- Volunteers
- 10,646 people
- Sponsor
- Abdul Latif Jameel Poverty Action Lab
Genital Herpes
Serologic Assays for the Diagnosis of Herpes Simplex Virus Type 2
The purposes of this study are: To determine the accuracy of commercially available serologic assays in diagnosing patients with herpes simplex virus type 2 (HSV-2); To assess the sensitivity and specificity of the commerical…
- Trial name
- NCT01112956
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
HIV Infections, Sexually Transmitted Diseases
Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
This randomized controlled trial conducted in Rakai District, Uganda, has enrolled 997 HIV positive men and 500 men who declined to learn HIV results (regardless of HIV status).
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Papillomavirus Infections, Genital Herpes
- Trial name
- NCT00124878
- Testing
- Male circumcision
- Where
- Uganda
- Volunteers
- 5,200 people, healthy volunteers welcome
- Sponsor
- Wawer, Maria J., M.D.
Herpes Simplex 2, Meningitis, Viral
Aciclovir Versus Placebo for HSV-2 Meningitis
To determine whether active treatment with (val)acyclovir is superior for treatment of viral meningitis compared with placebo assessed by numbers meeting a primary, objective endpoint at 7 days after randomisation
- Trial name
- AMEN (NCT05452928)
- Testing
- Acyclovir 50 MG/ML
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Jacob Bodilsen
Herpes Genitalis, HIV Infection
Randomised Controlled Trial Assessing the Impact of Genital Herpes Suppressive Therapy on HIV Shedding
Genital herpes is a long-life sexually transmitted diseases which infects a large proportion of women in Africa. Its clinical symptoms are painful sores on the genitals, which heals after a few days.
- Trial name
- NCT00158509
- Testing
- Valacyclovir
- Where
- Burkina Faso
- Volunteers
- 215 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Advanced Colorectal Carcinoma
First-line Maintenance of OH2 Injection for Advanced Colorectal Cancer
This is a prospective, multicenter, open, randomized controlled Phase II clinical study to evaluate the efficacy and safety of intratumoral injection of OH2 combined with capecitabine for first-line maintenance of advanced…
- Trial name
- NCT05648006
- Testing
- OH2, Capecitabine, Bevacizumab
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Binhui Biopharmaceutical Co., Ltd.