Clinical trials: Head Neck Neoplasms
CDKN2A-p16 Positive, HPV Positive Oropharyngeal Squamous Cell Carcinoma
Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer
This phase II trial studies how well alpelisib works in treating participants with human papillomavirus(HPV)-associated stage I-IVA head and neck cancer that can be removed by surgery.
- Conditions
- CDKN2A-p16 Positive, HPV Positive Oropharyngeal Squamous Cell Carcinoma, Stage I Oropharyngeal Squamous Cell Carcinoma AJCC V7, Stage II Oropharyngeal Squamous Cell Carcinoma AJCC V7
- Trial name
- NCT03601507
- Testing
- Alpelisib, Laboratory Biomarker Analysis, Pharmacodynamic Study
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arizona
Oral Cavity Squamous Cell Carcinoma
Biofeedback Rehabilitation to Improve Speaking and Eating in Public
Tongue cancer requires resection and reconstruction that can leave patients disabled with respect to speaking and eating. Impairment of tongue function can have significant impact on social interaction and employment.
- Trial name
- Biofeedback (NCT03650699)
- Testing
- Electropalatography Biofeedback Training
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Esophageal Cancer
Quality-of-Life Assessment of Patients Who Have Cancer of the Esophagus
RATIONALE: Questionnaires that measure quality of life may improve the ability to plan treatment for patients who have cancer of the esophagus.
- Trial name
- NCT00003321
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 10 sites in Australia, France and 6 more
- Volunteers
- 370 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin
An International Study on Pediatric Patients With Rare Tumors.
The PARTNER study is an international, prospective, observational study of paediatric patients with very rare tumours.
- Conditions
- Paraganglioma/ Phaeochromocytoma, Melanoma and Other Malignant Neoplasms of Skin, Gastrointestinal Stromal Tumor (GIST), Adrenocortical Tumor
- Trial name
- PARTNER (NCT07072143)
- Where
- Italy
- Volunteers
- 6,250 people
- Sponsor
- Azienda Ospedaliera di Padova
Nasopharyngeal Carcinoma (NPC)
Compassionate Use of Asparaginase and Pembrolizumab Combination Theaapy for Nasopharyngeal Carcinoma
The goal of this study is to investigate the outcomes of patients with locoregionally advanced nasopharyngeal carcinoma (LA-NPC) or recurrent-metastatic nasopharyngeal carcinoma (RM-NPC) treated with a combination of immune…
- Trial name
- NCT06676293
- Testing
- Anti-PD1, asparaginase
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- Chang Gung Memorial Hospital
Esophagus Cancer
Neoadjuvant Chemotherapy Compared With Surgery for Esophageal Carcinoma
Most ESCC received NAC in China without supportive evidence from local RCTs. The negative conclusion about NAC originated from Western countries in the 1990s.
- Trial name
- NCT05569668
- Testing
- Paclitaxel- and platinum-based chemotherapy
- Where
- China
- Volunteers
- 826 people
- Sponsor
- Henan Cancer Hospital
Thyroid Nodule
Radiofrequency Ablation in TIR3A Nodules With Negative Genetic Evaluation
The goal of this clinical trial is to demonstrate that TIR3A nodules with negative genetic test can be safely and effectively treated by radiofrequency ablation, with nodular shrinkage and improvement of clinical symptoms.
- Trial name
- NCT05765695
- Testing
- Radiofrequency ablation performed with a 19 gauge STARmed needle.
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Auxologico Italiano
Radiodermatitis; Acute, Radiotherapy Side Effect
The Use of Photobiomodulation in the Management of Radiodermatitis in Head and Neck Cancer Patients
It is estimated that there will be 670,000 new cases of cancer worldwide in 2020-2022 and it is known that the most commonly instituted treatments in cancer are chemotherapy, radiotherapy and surgery.
- Conditions
- Radiodermatitis; Acute, Radiotherapy Side Effect, Head and Neck Cancer
- Trial name
- NCT05557825
- Testing
- Photobiomodulation Therapy
- Where
- Brazil
- Volunteers
- 3 people
- Sponsor
- University of Nove de Julho
Thyroid Diseases, Thyroid Neoplasms
Computer Vision-Based Recognition of Parathyroid Glands and Recurrent Laryngeal Nerves in Endoscopic Surgery
This study aims to evaluate the performance of the PTAIR computer vision model for recognizing parathyroid glands and recurrent laryngeal nerves during endoscopic thyroid surgery.
- Trial name
- PTAIR (NCT07628543)
- Testing
- PTAIR Computer Vision Model Assessment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Medical University
Thyroid Cancer, Thyroid Neoplasms
IoN- Is Ablative Radio-iodine Necessary for Low Risk Differentiated Thyroid Cancer Patients
IoN is a phase II/III trial that will look to ascertain whether or not radio-iodine ablation is necessary for low risk differentiated thyroid cancer patients.
- Trial name
- IoN (NCT01398085)
- Testing
- I131 1.1 GBq, No Radioactive iodine (No-RAI) ablation
- Where
- 36 sites in United Kingdom
- Volunteers
- 504 people
- Sponsor
- University College, London
Esophageal Cancer
A Observational Study to Compare Effectiveness and Safety of the Surgeries in Patients With Esophageal Cancer
The study was designed to compare effectiveness and safety of the surgeries of Ivor-Lewis and Mckeown in patients with esophageal cancer
- Trial name
- NCT03428074
- Testing
- Surgeries
- Where
- 9 sites in China
- Volunteers
- 1,862 people
- Sponsor
- Chinese PLA General Hospital
Malignant Solid Neoplasm, Recurrent Adrenal Gland Pheochromocytoma
Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial
This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have recurred or spread to other places in the body (advanced), lymphoma, or histiocytic disorders, that have a…
- Conditions
- Malignant Solid Neoplasm, Recurrent Adrenal Gland Pheochromocytoma, Recurrent Ectomesenchymoma, Recurrent Ependymoma
- Trial name
- NCT04284774
- Testing
- Tipifarnib
- Where
- 172 sites in United States, Puerto Rico
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Nasopharyngeal Cancer
A Study of Nasopharyngeal Carcinoma From Guangdong
This prospective cohort study aims to establish prognostic models, to discover toxicity associated predictors and to validate randomized trials in clinical practice.
- Trial name
- NCT03003182
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-sen University
Neuroblastoma in Children, Neuroblastoma, Recurrent, Refractory
Expanded Access Protocol for the Use of SL-28 in the Treatment of Advanced Solid Tumors
This is an Expanded Access Program (EAP) that will give the participants access to the drug SL-28 before it is approved by the FDA.
- Conditions
- Neuroblastoma in Children, Neuroblastoma, Recurrent, Refractory, Advanced Cancer, Advanced Malignant Neoplasm
- Trial name
- NCT06872489
- Testing
- SL-28.
- Sponsor
- Second Life Therapeutics
Parathyroid Adenomas
Expanded Access:18F-Fluorocholine for the Detection of Parathyroid Adenomas
This expanded access protocol is proposed to allow University of California San Francisco (UCSF) patients additional access to 18F-fluorocholine (FCH) Positron Emission Tomography (PET) imaging for localization of parathyroid…
- Trial name
- NCT07218224
- Testing
- 18F-Fluorocholine (FCH), Positron emission tomography (PET)
- Sponsor
- Thomas Hope
Esophageal Cancer, Gastric Cancer
Surgery With or Without Combination Chemotherapy in Treating Patients With Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not known whether combining chemotherapy with surgery is more effective than surgery alone.
- Trial name
- NCT00002883
- Testing
- cisplatin, fluorouracil, adjuvant therapy
- Where
- France
- Volunteers
- 250 people
- Sponsor
- UNICANCER
Head Neck Neoplasms
Recipient Vessels for Free Tissue Flaps in Advanced Oncologic Defects of the Midface and Scalp
The goal of this clinical trial is to compare the postoperative outcomes based on superficial temporal versus cervical recipient vessels for midface and scalp advanced oncologic defects using free tissue flap for reconstruction.
- Trial name
- NCT05749120
- Testing
- Recipient vessel selected for microanastomosis
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Instituto Nacional de Cancer, Brazil
Graft vs Host Disease, Sjogren's Syndrome
Potential of Transplanted Stem Cells to Mature Into Salivary Gland and Cheek Cells
This study will examine whether transplanted stem cells can turn into salivary gland cells in stem cell recipients. If so, stem cells might be used to restore salivary gland function in patients with Sjogren's syndrome and other…
- Trial name
- NCT00023491
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Cancer of Esophagus, Gastric Cancer
Analysis of Body Composition in Relation to Outcome After Surgery in a Cohort of Patients With Esophageal Cancer
The occurrence of dysphagia is a well-known early feature of esophageal cancer that may reduce caloric intake and thus cause weight loss. Sarcopenia is considered to be a consequence of such involuntary nutritional restriction.
- Trial name
- NCT03032224
- Testing
- Resection of the esophagus and the gastroesophageal junction
- Where
- Sweden
- Volunteers
- 76 people
- Sponsor
- Vastra Gotaland Region
Oral Cancer
Response to Neoadjuvant Chemoimmunotherapy in Resectable Locally Advanced Oral Cancer
The goal of this observational study is to investigate the effectiveness of neoadjuvant chemoimmunotherapy (NACI) regimens in treating advanced oral squamous cell carcinoma (OSCC) patients.
- Trial name
- HNC-SYSU-005 (NCT06143761)
- Testing
- PD-1 inhibitor+carboplatin+albumin-bound paclitaxel
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University