Clinical trials: Head Trauma Injury
Brain Concussion
LED Therapy for the Treatment of Concussive Brain Injury
A double blind randomized trial of light-emitting diode (LED) therapy for patients suffering from mild traumatic brain injury (mTBI).
- Trial name
- NCT02383472
- Testing
- MedX Health Console model 1100
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Gait Impairment, Cerebral Palsy (CP)
Clinical Investigation to Validate the Safety and Performance of the ABLE Kids Device in Pediatric Patients With Neurological Gait Disorders in a Clinical Setting
The primary objective of the study is to validate the safety and clinical performance of the ABLE Kids device in pediatric patients with neurological gait disorders or muscular weakness during a 10-session gait training program…
- Conditions
- Gait Impairment, Cerebral Palsy (CP), Neuromuscular Diseases (NMD), Spinal Cord Injuries (SCI)
- Trial name
- NCT07745712
- Testing
- ABLE Kids
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- ABLE Human Motion S.L.
Stroke, Cerebral Palsy
Functional Engagement in Assisted Therapy Through Exercise Robotics
The investigators have assembled an integrated knowledge/technology/client team to develop a novel motion capture-based home therapy program for children with hemiparesis (cerebral palsy, acquired brain injury (ABI)) and older…
- Conditions
- Stroke, Cerebral Palsy, Traumatic Brain Injury
- Trial name
- FEATHERS (NCT02290353)
- Testing
- FEATHERS
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University of British Columbia
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Stroke, Incomplete Spinal Cord Injury
Comparing the Ceriter Stride One, a Pressure-sensitive Smart Insole, With Gait Parameters Measured on the GRAIL in Neurological Populations
Ceriter Stride-One soles have been available on the market for several years. One of the features of these soles is that they can measure gait parameters while patients walk around in a functional environment.
- Conditions
- Stroke, Incomplete Spinal Cord Injury, Traumatic Brain Injury, Acquired Brain Injury
- Trial name
- NCT07237386
- Testing
- Wearing smart insoles
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Ghent
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Children, Only, Traumatic Brain Injury
Neurophysiological Measurements Using the NeuroCatch™ Platform in Pediatric Concussion
EEG signals have been collected and studied since the early 1990's as a way of assessing brain function at a gross level. As early as the 1930's a derivative of the raw EEG signal - event-related potentials (ERPs) - have been…
- Conditions
- Children, Only, Traumatic Brain Injury, Concussion, Mild, Pediatric ALL
- Trial name
- NCT03889483
- Testing
- NeuroCatch™ Platform
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dr. Michael Esser
TBI (Traumatic Brain Injury)
Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury
Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.
- Trial name
- NCT05205174
- Testing
- depth electrodes
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
Trauma, Brain, Pediatric
Quantifying Brain Injury on Computed Tomography in Hospitalized Children
Lay Summary: To evaluate a novel early diagnostic tool for hospitalized children with traumatic brain injury. The Problem: Children who present with decreased level of consciousness after injury require urgent medical attention…
- Trial name
- QBIct (NCT04176640)
- Volunteers
- 425 people
- Sponsor
- The Hospital for Sick Children
Concussion, Brain, Motor Vehicle Accident
Research Evaluating Sports ConcUssion Events - Rapid Assessment of Concussion and Evidence for Return
RESCUE-RACER is jointly sponsored by the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. The RESCUE-RACER programme evaluates motorsports competitors at baseline (CArBON) and post-injury (CARS).
- Trial name
- RESCUE-RACER (NCT03844282)
- Testing
- Clinical assessment (SCAT5), ImPACT, CANTAB
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Concussion, Brain
Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial
Approximately 420 professional and amateur athletes will participate in rehabilitation during recovery after sports-related concussion. Participants will be cluster randomized, by study site, to a specific study arm.
- Trial name
- NCT02988596
- Testing
- Multidimensional Active Rehabilitation, Enhanced Graded Exertion
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Brain Injuries, Traumatic, Brain Injury Traumatic Moderate
A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of death, disability and cognitive impairment in young people worldwide. The majority of the traumatic deaths in developed countries results directly from lesions in the central…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe
- Trial name
- TBI-PRO (NCT03810222)
- Testing
- N/A (Observational Study)
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital
Traumatic Brain Injury
The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)
There are no therapeutic agents that have been shown to improve outcomes from severe traumatic brain injury (TBI). Critical barriers to progress in developing treatments for severe TBI are the lack of: 1) monitoring biomarkers…
- Trial name
- NCT04855396
- Where
- 11 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- University of Michigan
Residual Neurological, Cognitive, Emotional, Behavioral Effects From Traumatic Brain Injury
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Traumatic Brain Injury
Hypothesis: That SPECT brain imaging tracks and is consistent with clinical improvements in patients receiving hyperbaric oxygen therapy (HBOT) for chronic traumatic brain injury.
- Trial name
- NCT00594503
- Testing
- Hyperbaric oxygen therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Paul G. Harch, M.D.
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Concussion, Brain, Mild Traumatic Brain Injury
Oculogica Portable EyeBOX Study
The objective of this study is to assess the accuracy of a portable version of the EyeBOX device, an eye-tracking based diagnostic, in comparison to a clinical reference standard of concussion.
- Trial name
- RESTLESS (NCT05047003)
- Testing
- EyeBOX Model EBX-4 (Portable version)
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oculogica, Inc.
Concussion
Vascular Assessment of Regulation Index Arrays Registry
The objective of this patient registry is to collect and analyze physiological data associated with baseline and brain injury identified in standard clinical practice (Normal Values, Recovery Curves, Correlation between Symptoms…
- Trial name
- VARIA (NCT02435082)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- NeuroChaos Solutions, Inc.
Concussion
Primary Prevention of Concussion in Youth Ice Hockey Players
1. Background and Rationale: Little is currently known about intrinsic risk factors for sport-related concussion in youth ice hockey players.
- Trial name
- NCT03360786
- Testing
- Specific intervention, Control intervention
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sport Injury Prevention Research Centre
Minor Head Injury, Traumatic Brain Injury
Diagnostic Algorithm in Patients With Minor Head Injury
The objective of this prospective study is to evaluate the reliability of plain x-rays vs.cranial computed tomography as a screening method for skull fractures and its prognostic value for intracranial bleeding (ICB).
- Trial name
- NCT00452036
- Where
- Austria
- Volunteers
- 12,500 people
- Sponsor
- Medical University of Vienna