Clinical trials: Health Adults
Diffuse Midline Glioma (DMG), Glioblastoma
ONC206 for Treatment of Newly Diagnosed, Recurrent Diffuse Midline Gliomas, and Other Recurrent Malignant CNS Tumors
This phase I trial studies the effects and best dose of ONC206 alone or in combination with radiation therapy in treating patients with diffuse midline gliomas that is newly diagnosed or has come back (recurrent) or other…
- Conditions
- Diffuse Midline Glioma (DMG), Glioblastoma, Recurrent Ependymoma, Recurrent Malignant Central Nervous System Neoplasm
- Trial name
- PNOC023 (NCT04732065)
- Testing
- ONC206, Standard of Care Radiation Therapy, Optional Proton (1H) MR spectroscopy (MRS)
- Where
- 7 sites in United States, Netherlands and 1 more
- Volunteers
- 208 people
- Sponsor
- Sabine Mueller, MD, PhD
Psychological Disorder
Understanding the Impact of Death Conditions Linked to the COVID-19 Crisis on the Grieving Process in Bereaved Families
This study aims to analyze the grieving process of people who have lost a close first degree relative, understand the impact of death conditions and model a "theory of mourning" in the context of the COVID-19 crisis .
- Trial name
- COVIDAAD (NCT05566366)
- Testing
- Qualitative research interview
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma Intermittent, Uncontrolled
Feasibility of an Asthma Online Social Intervention
The goal of this observational study is to test the feasibility and acceptability of an online intervention for people with troublesome asthma in primary care, involving a consultation with a primary care clinician to introduce…
- Trial name
- NCT05829265
- Testing
- A digital social intervention by primary care clinicians.
- Where
- United Kingdom
- Volunteers
- 526 people
- Sponsor
- Queen Mary University of London
Influenza
Plasmablast Trafficking and Antibody Response in Influenza Vaccination (SLVP021 2011-2014)
The purpose of this study is to investigate the responses to licensed trivalent, inactivated influenza vaccine (TIV) delivered by different routes: intramuscular (IM) and intradermal (ID) and to the live, attenuated influenza…
- Trial name
- NCT02141581
- Testing
- Fluzone® (IM), Fluzone® Intradermal (ID), 2011-2012 FluMist®
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Stanford University
Lower Urinary Tract Symptoms (LUTS), Transition Care
Study of Transition in Real-life Experiences Affecting Micturition and Well-being in Adolescent Years
With this study, we would like to interview 16-25-year-olds who have experienced urinary problems since childhood and who are still experiencing symptoms in young adulthood.
- Conditions
- Lower Urinary Tract Symptoms (LUTS), Transition Care, Enuresis Nocturnal, Adverse Childhood Experiences
- Trial name
- STREAMWAY (NCT07339865)
- Testing
- Semi-structured in-depth interviews with standardized validated questionnaires, Completion of a urological time-line
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent
Acne, Patient Compliance
"A Randomized, Controlled, Evaluator-blinded Pilot Study to Evaluate the Effect of Automated Text Message Reminders on Patient Compliance With Topical Medications and Its Efficacy on Skin Disease Control in Adolescents and Adults With Mild to Moderate Acne"
The purpose of this study is to determine whether an automated electronic reminder system using text messages sent to patient's cell phones will help patients with acne be more compliant with their topical medications and lead to…
- Trial name
- NCT01082523
- Testing
- Text message reminders
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Pediatric Cancer, Adolescent and Young Adult Cancer
Improving Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention
The overarching goal is to develop and demonstrate proof-of-concept of ReSPECT (Reproductive and Sexual Health Patient Education and Communication Tool), a multi-modal communication intervention to improve adolescent and young…
- Trial name
- NCT06982066
- Testing
- ReSPECT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Connecticut Children's Medical Center
Overweight, Obesity
Family Partners for Health
Young children who are overweight or at risk for overweight are at increased risk for becoming obese as young adults and developing type 2 diabetes and cardiovascular disease.
- Trial name
- WEIGHT (NCT01378806)
- Testing
- Nutrition and exercise education and coping skills training
- Where
- United States
- Volunteers
- 718 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Mental Health Literacy
Design, Implementation and Evaluation of an Intervention Within Video Game for Mental Health Literacy in Adolescents and Young Adults
Context Adolescence and early adulthood are crucial periods for the development and maintenance of habits, behaviors and beliefs favorable to health and mental well-being.
- Trial name
- SCOTT (NCT06473857)
- Testing
- Mental health literacy intervention, Non mental health intervention
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma in Children
The Effect of Health Care Transition Based Education Given to Adolescents With Asthma
Aim: The purpose of this study was to examine the effect of health care transition-based education on transition readiness and self-efficacy in adolescents (14-18 years) with asthma through a randomized controlled experimental…
- Trial name
- NCT05550922
- Testing
- Healthcare Transition-Based Education
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Smoking, Smoking Cessation
Comparison of Four Different Smoking Cessation Programmes
The primary objective of the study is to compare the efficacy of four different smoking cessation programmes, including a proactive telephone counseling intervention, a reactive telephone counseling a and an interactive web-based…
- Conditions
- Smoking, Smoking Cessation, Self-efficacy
- Trial name
- Fristart (NCT01487642)
- Testing
- Standard 15-minute telephone counselling, Proactive telephone counselling, Interactive web-based smoking cessation programme
- Where
- Denmark
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Multiple Osteochondroma, Osteogenesis Imperfecta
Resilience and Coping in a Rare Skeletal Disease Population to Face Coronavirus (COVID-19) Outbreak Distress: a Longitudinal Study
In the COVID-19 outbreak context, people living with rare diseases have been highly troubled with anxiety, loneliness, and depression.
- Conditions
- Multiple Osteochondroma, Osteogenesis Imperfecta, Ollier Disease, Maffucci Syndrome
- Trial name
- RELOAD (NCT04844697)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Ortopedico Rizzoli
Bardet-Biedl Syndrome
Characterizing the Genotype and Phenotype in Adults With Bardet-Biedl Syndrome
Bardet-Biedl syndrome (BBS; OMIN #209900) is a rare genetic disorder characterized by six core features: rod-cone dystrophy (retinitis pigmentosa), polydactyly, obesity, genital anomalies, renal anomalies, and learning…
- Trial name
- NCT05400278
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Cardiometabolic Health
Trajectory Study: Predicting Cardiometabolic Health in Adolescents and Young Adults Based on Childhood Fitness, Sleep, and Diet
The Trajectory study aims to determine whether childhood aerobic fitness, sleep quality, and diet quality predict cardiometabolic health during puberty and early adulthood, independently of adiposity.
- Trial name
- Trajectory (NCT06913985)
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Frailty
Supporting Uptake of Evidence for Physical Activity in Older Adults With Complex Health Care Needs
Physically frail older adults often have chronic conditions that contribute to a higher chance of them being limited in daily activities and becoming dependent.
- Trial name
- Moving_More (NCT06894914)
- Testing
- 24-hour Activity Counselling
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Transgender Individuals
Effects of Gender-Affirming Hormone Therapy on Cardiovascular, Metabolic, and Mental Health Outcomes in Transgender Adults.
The objective of this observational study is to examine the impact of gender-affirming hormone therapy (GAHT) on mood in transgender individuals and to explore its potential association with early atherosclerotic processes.
- Trial name
- NCT07394400
- Where
- Spain
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Milagros Rocha Barajas
Anxiety, Depression
Virtual Intervention for Behavioral Health in Emerging Adults; "VIBE in the Parks"
The goal of this study is first to develop and adapt a digital low-intensity treatment, "VIBE in the Parks", for adolescents and young adults (AYA) who visit programming at the Chicago Park District.
- Trial name
- VIBE (NCT07539636)
- Testing
- "VIBE in the Parks", Digital Control
- Volunteers
- 268 people
- Sponsor
- University of Illinois Chicago
Rare Bone Disorders
Ready to Sail 2: A Pilot Study of Sail-Assisted Telerehabilitation in Rare Skeletal Diseases
"Ready to Sail 2 - EXTEND" is a pilot randomized interventional trial designed to assess the feasibility, safety, and preliminary impact of an innovative rehabilitation model combining sailing therapy (velatherapy) with a remote…
- Trial name
- PaS2-EXTEND (NCT07102875)
- Testing
- Sailing Intervention Plus Home-Based Telerehabilitation, Home-Based Telerehabilitation
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Ortopedico Rizzoli
Asthma Control, Pulmonary Function
Asthma Intervention With Residential Ventilation and Air Cleaner (AIRVAC) Study
The primary goal of this study is to investigate the comparative long-term (i.e., 1-year) effectiveness of energy recovery ventilators (ERVs) and portable air cleaners (PACs) in reducing indoor air pollutants and mold levels and…
- Conditions
- Asthma Control, Pulmonary Function, Quality of Life, Stress
- Trial name
- NCT07196436
- Testing
- Energy Recovery Ventilator, Portable Air Cleaner
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- The University of Texas at Arlington
Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma
Mobile Health Intervention to Support Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia
This is a small-scale micro-randomized clinical trial of a new mobile just-in-time adaptive intervention (JITAI) designed to promote oral chemotherapy adherence in adolescents and young adults (AYA) with acute lymphoblastic…
- Trial name
- NCT03932903
- Testing
- ADAPTS (ADherence Assessments and Personalized Timely Support).
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University