Clinical trials: Healthy Participants Study
Hemorrhagic Fever, Ebola
Long-term Safety Follow-up of Participants Exposed to the Candidate Ebola Vaccines Ad26.ZEBOV and/or MVA-BN-Filo
The purpose of the study is to assess the long-term safety profile of Ad26.ZEBOV and MVA-BN-Filo in participants previously exposed to these vaccines in Phase 1, 2, or 3 clinical studies.
- Trial name
- NCT02661464
- Testing
- Ad26.ZEBOV, MVA-BN-Filo
- Where
- 16 sites in United States, Burkina Faso and 5 more
- Volunteers
- 677 people, healthy volunteers welcome
- Sponsor
- Janssen Vaccines & Prevention B.V.
Multiple Sclerosis
The Effect of Sildenafil Citrate (Viagra® (Registered Trademark)) on Brain Blood Flow in Multiple Sclerosis Patients
This study will determine whether sildenafil citrate, commonly known as Viagra, can cause increased blood flow to the brain in a wide range of multiple sclerosis (MS) patients, including women.
- Trial name
- NCT00094068
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Impaired Hepatic Function, Healthy
Study of ALXN2050 in Participants With Hepatic Impairment
This study will investigate the impact of impaired hepatic function (IHF) on the plasma pharmacokinetics of ALXN2050 in order to provide dosing recommendations for future indications in individuals with varying degrees of IHF.
- Trial name
- NCT05259085
- Testing
- ALXN2050
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Healthy
Non-Inferiority Study Comparing the Subunit Vaccines Influvac and Agrippal in China
In the study Influvac will be compared to Agrippal, another subunit influenza vaccine that is already on the market in China. The main objective of the study is to show that both vaccines are comparable with regard to efficacy.
- Trial name
- NCT00325260
- Testing
- Influvac; subunit influenza vaccine
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Meningococcal Disease
Safety of One Dose of Meningococcal ACWY Conjugate Vaccine in Subjects From 2 Months to 55 Years of Age in the Republic of South Korea
A multicenter, single arm, post-marketing surveillance study. This study is a postlicensure requirement of the Korea Food and Drug Administration (KFDA) to provide continued safety evaluation of MenACWY in the Korean population…
- Trial name
- NCT01766206
- Testing
- MenACWY-CRM (Menveo)
- Where
- 54 sites in South Korea
- Volunteers
- 3,948 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Transcranial Magnetic Stimulation to Study Imagination of Movement
This study will use transcranial magnetic stimulation (TMS) to examine the relationship between cognitive processing and motor control by determining whether a part of the brain called the premotor cortex is essential to…
- Trial name
- NCT00046215
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Internet Addiction
The Effect of the Mobile EEG-Neurofeedback in Healthy Child and Adolescent
The objective of this study was to ascertain the therapeutic impact of mobile neurofeedback (MNF) in neurotypical children when compared to sham MNF.
- Trial name
- NCT06388655
- Testing
- mobile neurofeedback
- Where
- South Korea
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Healthy Participants, Infants
First Complementary Foods and the Infant Gastrointestinal Microbiota
This study evaluates the effect of different complementary foods on the gastrointestinal microbiota of exclusively human milk fed infants.
- Conditions
- Healthy Participants, Infants, Gastrointestinal Microbiota
- Trial name
- NCT05492253
- Testing
- Infant fruit, Infant vegetable, Infant meat
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Healthy Subjects
A Multi-Center, Vehicle-Controlled, Parallel-Group Study Evaluating the Safety of AC-170 Ophthalmic Solution
This is study is evaluating the safety and tolerability of AC-170 Ophthalmic Solution
- Trial name
- NCT02756624
- Testing
- AC-170 0.24%, AC-170 Vehicle
- Where
- United States
- Volunteers
- 516 people
- Sponsor
- Nicox Ophthalmics, Inc.
Tropical Spastic Paraparesis
MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis
This study will use three different magnetic resonance imaging (MRI) techniques to study HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/STP)-a disease of slowly progressive weakness in the legs.
- Trial name
- NCT00034723
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Asthma, Chronic Obstructive Pulmonary Disease
EXhaled Hydrogen Peroxide As a Marker of Lung diseasE (EXHALE) Pilot Study.
This Pilot study evaluates the use of a new device called Inflammacheck and whether it can consistently measure hydrogen peroxide levels in exhaled breath condensate.
- Trial name
- EXHALE Pilot (NCT03055923)
- Testing
- The Inflammacheck Device
- Where
- United Kingdom
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Dysautonomia in Children With Type 1 Diabetes, Healthy Volunteer
Dysautonomia in Children With Type 1 Diabetes
Some physiological factors, such as physical activity, or pathological factors, such as sepsis or diabetes, are known to modulate the overall autonomic activity and the individual's intrinsic capacity to regulate their…
- Trial name
- DYSDIAB (NCT07455994)
- Testing
- Neurocoach® and Sudoscan®
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Healthy Volunteer
A Single-volunteer Study of Immune Response Following OTS-412 Vaccinia Virus Systemic Injection(Self-experiment)
Following oncolytic virus (OV) administration, the host immune response is initiated immediately and evolves dynamically. However, in clinical OV therapy, it is virtually impossible to capture these immune events in real time.
- Trial name
- NCT07302945
- Testing
- OTS-412
- Where
- South Korea
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bionoxx Inc.
Biological Availability
Bioavailability of Omega-3 Food Supplement in Healthy Subjects
The study will evaluate the relative bioavailability of Pronovum PRF-037 and Pronovum PRF-041 with PronovaPure 150:150 EE EU and Eskimo-3 (500 mg omega-3 acid triglyceride containing 80 mg EPA and 50 mg DHA per gram oil) in…
- Trial name
- NCT02376608
- Testing
- Pronova Pure 150:500 EE EU, Pronovum PRF-037, Pronovum PRF-041
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pronova BioPharma
Medulloblastoma, Childhood, Healthy Volunteers
Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
One of the major complications of posterior fossa surgery is Posterior Fossa Syndrome (PFS). This syndrome is due to a possible complication of surgical excision of a tumor of the cerebellum (4th ventricle) and is characterized…
- Conditions
- Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
- Trial name
- CervIRM (NCT04174820)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- 5 sites in France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Any Disease or Condition, Healthy
UCSF Research Participant Registry
The UCSF Clinical and Translational Science Institute (CTSI) Consultation Service provides recruitment services and facilitates the enrollment of research participants into UCSF clinical studies.
- Trial name
- NCT01717378
- Where
- United States
- Volunteers
- 1,541 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cystic Fibrosis, Asthma
Xenon-129 and Inert Fluorinated Gas Lung MRI: Study of Healthy Volunteers and Participants With Pulmonary Disease
Aim of this study is to evaluate image quality and reproducibility of Xenon-129 and Inert fluorinated (19F) gas Magnetic Resonance Imaging (MRI) and to evaluate changes in lung structure and function in participants with cystic…
- Trial name
- NCT02740868
- Testing
- Xenon-129 and Perfluoropropane (19F), Magnetic Resonance Imaging, Lung Clearance Index
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Healthy Subjects
Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents
Evaluate the pharmacokinetics (PK), Safety and tolerability of guaifenesin (Mucinex®) in an immediate-release formulation when a single dose is administered in adolescents and in adults when compared to Children.
- Trial name
- NCT03633448
- Testing
- Children's Mucinex® Grape Flavor
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser LLC
Other
A Study of IW-6463 in Healthy Volunteers
Stage 1: To assess the safety and tolerability of single-ascending-dose levels of IW-6463 tablets when administered orally to healthy subjects Stage 2: To assess the safety and tolerability of multiple-ascending-dose levels of…
- Trial name
- NCT03856827
- Testing
- IW-6463
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Tisento Therapeutics
Measles, Mumps
Immunogenicity and Safety of Concomitant Administration of MMR™ rHA and VARIVAX® by Intramuscular Versus Subcutaneous Route (V205C-011)
Primary objective: To compare if, when given concomitantly with VARIVAX® by the same route at 12-18 months of age using separate injection sites, a single dose of M-M-RTMII administered by IM route is as immunogenic as a single…
- Conditions
- Measles, Mumps, Varicella
- Trial name
- NCT00432523
- Testing
- M-M-R™II manufactured with recombinant Human Albumin (rHA) and VARIVAX®
- Where
- 2 sites in France, Germany
- Volunteers
- 752 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC