Clinical trials: Heart Conduction Disorder
Presyncope, Arrhythmias, Cardiac
The IPED (Investigation of Palpitations in the ED) Study
Palpitations (noticeable pounding, fluttering or irregular heart beat) and pre-syncope (near blackout) are common ED problems sometimes due to an abnormal cardiac rhythm.
- Conditions
- Presyncope, Arrhythmias, Cardiac, Tachycardia, Supraventricular, Atrial Fibrillation
- Trial name
- IPED (NCT02783898)
- Testing
- AliveCor Heart Monitor
- Where
- 10 sites in United Kingdom
- Volunteers
- 243 people
- Sponsor
- NHS Lothian
Long QT Syndrome, Brugada Syndrome
Physical Activity in Children With Inherited Cardiac Diseases
Use lay language. Current guidelines regarding physical activity in patients with inherited arrhythmia and cardiomyopathy are mostly dedicated to adult patients, with a special focus on sports competition.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia, Hypertrophic Cardiomyopathy
- Trial name
- NCT04650009
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Montpellier
Sudden Cardiac Death
CIQTP Prolongation : Role and Mechanism in Sudden Cardiac Death
Despite major progress in molecular and phenotypic characterization of primary electrical disorders, many (aborted) sudden cardiac deaths (SCD) occur in young victims without identifiable abnormalities.
- Trial name
- IQARE-SCD (NCT03387072)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 394 people
- Sponsor
- Nantes University Hospital
Brugada Syndrome, Early Repolarization Syndrome
VF Mapping in Brugada and Early Repolarization Syndromes
To determine the values and limitations of ECGI in guiding ablation and risk stratification in patients with BrS and Early Repolarization.
- Trial name
- NCT03764592
- Testing
- radiofrequency ablation
- Where
- 2 sites in Thailand
- Volunteers
- 50 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Ventricular Tachycardia, Ventricular Fibrillation
Pediatric Lead Extractability and Survival Evaluation (PLEASE)
This is a randomized, prospective clinical trial comparing 2 different types of implantable cardioverter defibrillator (ICD) leads in children and patients with congenital heart disease.
- Conditions
- Ventricular Tachycardia, Ventricular Fibrillation, Cardiomyopathy, Long QT Syndrome
- Trial name
- NCT00335036
- Testing
- ICD lead implant, Thin leads
- Where
- United States
- Volunteers
- 748 people
- Sponsor
- Charles Berul
Long QT Syndrome
KCNQ1 Cascade Screening
The objectives of the protocol are to: (1) evaluate the uptake of cascade screening and preventative therapies after the implementation of a simplified screening process and (2) assess proband and family member perspectives about…
- Trial name
- NCT03783975
- Testing
- Simplified Cascade Screening
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Tachycardia, Ventricular
Ablation Targets of Scar-related Ventricular Tachycardia Identified by Dynamic Functional Substrate Mapping
This study aims at comparing the recurrence rates of ventricular tachycardia ablated after being mapped by 2 different techniques.
- Trial name
- NCT05086510
- Testing
- Radiofrequency ablation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cardiovascular Diseases, Heart Diseases
Long QT Syndrome-Population Genetics and Cardiac Studies
To investigate the clinical, genetic and cardiologic aspects of the Long QT Syndrome, a predominantly hereditary disease with episodic malignant arrhythmias and sudden death, and a demonstrated gene linkage in a large pedigree.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Ventricular Arrhythmia, Long QT Syndrome
- Trial name
- LQTS (NCT00005176)
- Where
- United States
- Volunteers
- 2,125 people
- Sponsor
- University of Rochester
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Tachyarrhythmias, Heart Failure
Safety and Clinical Performance of the Protecta ICD and CRT-D
The purpose of the study is two-fold. In Phase I (Protecta Clinical Study), system performance will be evaluated. In Phase II (PainFree SST), the inappropriate shock-free rate at one year of subjects implanted with a Medtronic…
- Conditions
- Tachyarrhythmias, Heart Failure, Ventricular Dysfunction
- Trial name
- NCT00982397
- Testing
- Protecta VR-ICD, Protecta DR-ICD or CRT-D
- Where
- 122 sites in United States, Austria and 19 more
- Volunteers
- 2,770 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Supraventricular Tachycardia
Dexmedetomidine and Adenosine: Therapeutic Use for SVT
The purpose of this study is to evaluate the efficacy and safety of dexmedetomidine in the acute termination of Supraventricular Tachycardia (SVT).
- Trial name
- NCT01495481
- Testing
- Dexmedetomidine, Adenosine
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Pittsburgh
Tachyarrhythmia
Effectiveness of the Eko Digital Stethoscope in Capturing Infant ECGs
When a newborn is diagnosed with tachyarrhythmia, they are generally started on medical therapies, most commonly a beta-blocker, while being observed in an inpatient setting.
- Trial name
- NCT06382207
- Testing
- Eko Duo electronic stethoscope, CORE 500 electronic stethoscope
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Virginia Commonwealth University
Congenital Complete Heart Block, Cardiac Conduction Defect Progressive
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms
Identification of genes involved in congenital atrioventricular block and progressive Cardiac Conduction Disease.
- Trial name
- NCT02881671
- Testing
- genetic blood analysis
- Where
- 2 sites in France
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Cardiac Arrest, Sudden, Ventricular Tachycardia
Cardiopulmonary Resuscitation Performance of Professional Rescuers With a New Defibrillation Algorithm
In the Paris (France) Medical Emergency system, in the early phase of Out-of-hospital Cardiac Arrest (OHCA), the treatment of a Ventricular Fibrillation (VF) consists of delivering an External Electric Shock (EES) by a rescuer…
- Conditions
- Cardiac Arrest, Sudden, Ventricular Tachycardia, Ventricular Fibrillation, Sudden Cardiac Death
- Trial name
- DEFI-2022 (NCT04691089)
- Where
- France
- Volunteers
- 285 people
- Sponsor
- French Defence Health Service
Long QT Syndrome
The Canadian National Long QT Syndrome Registry
The NLQTS Research Network team aims to build a Canadian collaboration of dedicated investigators that will create a new paradigm in the modern investigation of patients with LQTS and in the description of a new disease modifier.
- Trial name
- LQTSREG (NCT02425189)
- Where
- Canada
- Volunteers
- 1,051 people
- Sponsor
- Andrew Krahn
Sick Sinus Syndrome
The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome
Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system.
- Trial name
- NCT01310920
- Testing
- observation
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Bundle-Branch Block
Congenital or Idiopathic Complete Right Bundle Branch Block: Physiological Significance and Molecular Characterization
This study is to determine 1) the incidence of altered right bundle conduction, including CRBBB, IRBBB or rsR' pattern in the Taipei city based on the school survey databank from 1999 to 2002, 2) the associated cardiac lesions…
- Trial name
- NCT00173342
- Where
- 2 sites in Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiac Disease, Syncope
Second Study on Cardio-neuromodulation in Humans
Different approaches to cardio-neuroablation (CNA) to treat neurally mediated syncope, sinus node dysfunction, and functional atrioventricular block have been published.
- Conditions
- Cardiac Disease, Syncope, Syncope, Vasovagal, Sick Sinus Syndrome
- Trial name
- CardNMH2 (NCT02954666)
- Testing
- radio-frequency ablation
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Imelda Hospital, Bonheiden
COVID, Arrhythmia
COVIDAR - Arrhythmias in COVID-19
BACKGROUND AND RATIONALE: There is very limited literature available on the arrhythmia occurrence in the context of an infection by the SARS-CoV2 virus.
- Conditions
- COVID, Arrhythmia, Torsades de Pointe Caused by Drug, Qt Interval, Variation in
- Trial name
- COVIDAR (NCT04437901)
- Where
- 5 sites in Belgium, Italy and 3 more
- Volunteers
- 10,000 people
- Sponsor
- Hospital Clinic of Barcelona
Bradycardia, Arrhythmias
Heart Rate Response to Atropine Doses Less Than 0.1mg IV to Anesthetized Infants
An infants heart rate is very important because it ensures that blood is pumped to all organs in the body. Heart rate may decrease during anesthesia and surgery, and this is why the anesthesiologist will often give a medication…
- Trial name
- NCT01819064
- Testing
- Atropine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- State University of New York at Buffalo