Clinical trials: Heart Defects
Acute Kidney Injury
Hematologic Ratios in Postoperative Acute Kidney Injury
Acute kidney injury (AKI) is a common complication after surgery for congenital heart disease and is associated with significant morbidity and mortality.
- Trial name
- NCT03658148
- Testing
- Cardiac Surgery with Cardiopulmonary Bypass
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Congenital Heart Disease
A Study to Evaluate MEDI-524 In Children With Hemodynamically Significant Congenital Heart Disease
The primary goal was to describe the safety of the investigational product when given monthly to prevent serious respiratory infection among children with significant heart disease.
- Trial name
- NCT00538785
- Testing
- Motavizumab, Palivizumab
- Where
- 152 sites in United States, Austria and 15 more
- Volunteers
- 1,236 people
- Sponsor
- MedImmune LLC
Tetrology of Fallot, Pulmonary Stenosis
MASA Valve Early Feasibility Study
The MASA Valve Early Feasibility Study (MVEFS) multi-site interventional clinical trial within the United States of America with each center following a common protocol.The objective of the trial is to evaluate the safety and…
- Conditions
- Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels
- Trial name
- MVEFS (NCT05452720)
- Testing
- Surgical Right Ventricular Outflow Tract Reconstruction
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- PECA Labs
Congenital Heart Defect, Right Ventricular Outflow Tract Reconstruction
Contegra Versus Pulmonary Homograft for Right Ventricular Outflow Tract Reconstruction in Newborns
Pulmonary homografts are standard substitutes for right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately shortage and conduit failure secondary to early calcifications and shrinking are observed…
- Trial name
- NCT03348397
- Testing
- right ventricular outflow tract reconstruction with contegra, right ventricular outflow tract reconstruction with pulmonary homograft
- Where
- Belgium
- Volunteers
- 53 people
- Sponsor
- Queen Fabiola Children's University Hospital
AKI - Acute Kidney Injury, Arrythmia
Tailored MgSO4 Supplementation to Reduce Complications in Pediatric Heart Surgery
Lay Summary This study tests two ways of measuring blood magnesium after heart surgery. Children who need heart surgery may have heart and kidney problems after surgery. The right amount of magnesium in blood reduces this risk.
- Conditions
- AKI - Acute Kidney Injury, Arrythmia, Congenital Heart Disease
- Trial name
- NCT06564376
- Testing
- total magnesium, ionized magnesium
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- West Virginia University
Univentricular Heart
Fontan-Sprechstunde
After successful Fontan surgery, the risk of mortality in childhood is only low. Unfortunately, some of the patients suffer from Fontan-typical long-term complications in the long-term course, whereby protein loss neuropathy must…
- Trial name
- NCT05563376
- Testing
- Univentricular Hearts
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Congenital Heart Disease
Cardiac Biomarker in Pediatric Heart Disease
The purpose of this study is to investigate cardiac biomarker during perioperative management in pediatric cardiac surgery.
- Trial name
- NCT01834976
- Where
- Japan
- Volunteers
- 74 people
- Sponsor
- Okayama University
Heart Defects, Congenital
Long-term Effects of Family WISH Program for Adolescents With Congenital Heart Disease
The goal of this clinical trial is to learn the long-term effects of "Family Walking Instruction with Support by Heart" (Family WISH) on frailty state, quality of life and family functioning among adolescents with congenital…
- Trial name
- NCT06719323
- Testing
- Family Walking Instruction with Support by Heart (Family WISH) program, Comparison group
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Chi-Wen Chen
Congenital Heart Disease, Adolescent Behavior
Effectiveness of an mHealth Intervention for Youth With Congenital Heart Disease
The aims of this study were to evaluate the long-term effectiveness of the Care \& Organize Our Lifestyle (COOL) program, a self-regulation theory-based mHealth program, on improving disease knowledge and physical activity in…
- Trial name
- NCT04264650
- Testing
- an mHealth intervention
- Where
- Taiwan
- Volunteers
- 143 people
- Sponsor
- National Yang Ming Chiao Tung University
Patients Who Underwent Surgery for Congenital Heart Disease
Influence of Tidal Volume During Mechanical Ventilation on Postoperative Clinical Outcome in Pediatric Patients Undergoing Congenital Heart Surgery
High tidal volume during mechanical ventilation has been reported to increase mortality in patients with acute lung injury or acute respiratory distress syndrome.
- Trial name
- NCT02081274
- Testing
- Surgery for congenital heart disease
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Samsung Medical Center
Arrhythmia, Congenital Heart Defect
Evaluation and Treatment of Heart Disease in Patients Not Participating in Research
There is an important need to maintain clinical skills, provide quality training and expertise, and provide an environment that stimulates ideas for clinical research.
- Conditions
- Arrhythmia, Congenital Heart Defect, Heart Disease
- Trial name
- NCT00001460
- Testing
- inpatient evaluation and management
- Where
- United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Congenital Heart Defect
XFM: (X-ray Fused With MRI) Guided Cardiac Catheterization
This study will evaluate the use of x-ray fused with MR images as an imaging tool to help guide catheter tools during diagnostic and therapeutic cardiac catheterization procedures.
- Trial name
- NCT02737579
- Testing
- XFM guidance
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Joshua Kanter
Congenital Heart Defect
Use of ROTEM® in Pediatric Cardiac Surgical Patients
Cardiac surgery requiring use of a heart-lung machine, also known as cardiopulmonary bypass (CPB) can induce abnormalities in blood coagulation (clotting) that lead to excessive blood loss during and after operation.
- Trial name
- PedsROTEM (NCT01212289)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Weill Medical College of Cornell University
Congenital Heart Disease
Relationship of Brain Natriuretic Peptide (BNP) Levels to Cardiac Diagnosis, Operation Performed, Post-operative Course and Outcome
The purpose of this study is to assess brain natriuretic peptide levels to evaluate the relationship of those levels with the diagnosis of congenital cardiac disease, operation performed, post-operative course, and outcome.
- Trial name
- NCT00238810
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Healthcare of Atlanta
Barth Syndrome
Resistance Exercise in Barth Syndrome
Barth syndrome (BTHS) is a disorder that is characterized by heart failure, exercise intolerance and skeletal muscle weakness. Preliminary evidence demonstrates that endurance exercise training does not significantly improve…
- Trial name
- NCT01629459
- Testing
- Resistance exercise and protein supplementation
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Patent Ductus Arteriosus
Closure of Patent Ductus Arteriosus With Indomethacin or Ibuprofen in Extreme Low Birth Weight Infants
Pharmacological closure of ductus arteriosus with prostaglandin (PG) inhibitors has been used for years. Previous studies indicated that ibuprofen has similar effect on ductal closure as indomethacin but has less adverse effects…
- Trial name
- NCT01758913
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Taipei Medical University Hospital
Congenital Heart Defects
An Evaluation of Routine Developmental Follow-Up in Infants and Children With Congenital Heart Disease
The purpose of this study is to understand how having a heart problem affects development,quality of life, and family life in young children and their families.
- Trial name
- NCT01567579
- Where
- United States
- Volunteers
- 928 people
- Sponsor
- Medical College of Wisconsin
Ehlers-Danlos Syndrome, Stickler Syndrome
Studies of Heritable Disorders of Connective Tissue
Background: Heritable disorders of connective tissue are genetic conditions that can affect the skin and other parts of the body. They are related to mutations in genes that are responsible for building tissues.
- Conditions
- Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome
- Trial name
- NCT00270686
- Where
- United States
- Volunteers
- 929 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Heart Defects, Congenital, Hypoplastic Left Heart Syndrome
Fluid Balance in Children Undergoing Fontan Surgery
This project will evaluate fluid balance and edema formation in children with congenital heart disease in need of a surgical procedure, The Fontan procedure.
- Trial name
- NCT02306057
- Testing
- Pre BCPC, Pre TCPC, BCPC surgery
- Where
- Norway
- Volunteers
- 39 people
- Sponsor
- Oslo University Hospital
Azithromycin Adverse Reaction, Covid19
The Effect of Azithromycin Use on Conduction System of Heart in COVID-19 Positive Children
Azithromycin (AZ) is used in the pediatric group in COVID-19 diseas. It has been reported to cause prolongation in the QT interval in adult age group.
- Conditions
- Azithromycin Adverse Reaction, Covid19, Long QT Syndrome
- Trial name
- NCT04699097
- Testing
- Azithromycin
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Kayseri City Hospital
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