Clinical trials: Heart Defects
Alagille Syndrome
A Study to Observe the Long-term Safety of Odevixibat in Patients With Alagille Syndrome (ALGS) Who Are Receiving Ongoing Treatment
This study will collect information from patients with ALGS who are using odevixibat in their daily lives. Odevixibat is a medication that helps patients with ALGS, a rare disease that affects the liver and causes itching.
- Trial name
- NCT07585097
- Where
- 14 sites in France, Italy
- Volunteers
- 30 people
- Sponsor
- Ipsen
Patent Ductus Arteriosus
Patent Ductus Arteriosus and Splanchnic Oxygenation at First Feed
Patent ductus arteriosus (PDA) is common in preterm infants. In the presence of a large PDA, significant systemic to pulmonary shunting occurs, which may results in pulmonary hyperperfusion and systemic hypoperfusion.
- Trial name
- NCT03723889
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Congenital Heart Disease, Desaturation of Blood
Evaluation of VITLS Compared to Traditional Inpatient Monitoring in Cardiac Shunt-Dependent Children
We are seeing how well a remote monitoring device that looks like a sticker placed on the chest, under the arm can monitor a child's vital signs including oxygen levels compared to the way that we usually get these measurements.
- Trial name
- NCT05526768
- Testing
- VITLS Device
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Baylor College of Medicine
Transposition of Great Vessels, Tetralogy of Fallot
Effects Branch PA Stenting d-TGA, ToF and TA
The goal of this randomized controlled trial is to identify the effects of percutaneous interventions for branch PA stenosis on exercise capacity in patients with d-TGA, ToF and TA.
- Conditions
- Transposition of Great Vessels, Tetralogy of Fallot, Truncus Arteriosus, Pulmonary Artery Stenosis Supravalvular Congenital
- Trial name
- NCT05809310
- Testing
- Percutaneous intervention (stent) for PA stenosis
- Where
- 4 sites in Netherlands
- Volunteers
- 56 people
- Sponsor
- UMC Utrecht
Congenital Heart Disease
Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary Bypass
Newborn babies and children with congenital heart defects who need heart surgery need to be placed on the heart-lung machine for heart surgery.
- Trial name
- PBUF (NCT03576534)
- Testing
- Use of prebypass ultrafiltration (PBUF)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Children's Hospital
Tetralogy of Fallot, Pulmonary Regurgitation
Early Versus Later Re-valving in Tetralogy of Fallot With Free Pulmonary Regurgitation
Tetralogy of Fallot (ToF) is a congenital heart defect with four major features including right ventricular outflow tract obstruction. About 25 children are born with this condition in Denmark every year.
- Trial name
- NCT04084132
- Testing
- Pulmonary valve replacement
- Where
- 3 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Congenital Heart Disease, Postoperative Care
Empowering Families in Pediatric Cardiovascular Surgery: A RAM-Based Approach
The purpose of this clinical trial is to learn about the effects of a nursing support program designed for families of children aged 1 to 3 years who have undergone heart surgery.
- Conditions
- Congenital Heart Disease, Postoperative Care, Child Development, Roy Adaptation Model-based Nursing Empowerment Program
- Trial name
- NCT07575451
- Testing
- RAM-based Nursing Empowerment Program, Routine Care and Educational Booklet
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Cukurova University
Patent Foramen Ovale, Atrial Septal Defect
Lifetech CeraFlex™ Post-Market Surveillance Study
The purpose of this multi-center, non-interventional, prospective, post-market clinical study is to collect real world data on patient outcomes and evaluate the procedural success and performance of the Lifetech CeraFlex™…
- Conditions
- Patent Foramen Ovale, Atrial Septal Defect, Patent Ductus Arteriosus
- Trial name
- NCT02621528
- Testing
- CeraFlex
- Where
- 7 sites in France, Germany and 3 more
- Volunteers
- 120 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Tetralogy of Fallot
Cardiac Function Under Stress for Early Detection of the Right Ventricular Insufficiency After Repair of Tetralogy of Fallot
Summary: The investigators aim to identify markers of right ventricular dysfunction in patients with severe pulmonary regurgitation following repair of Tetralogy of Fallot, that allow prediction of the optimal timing of the…
- Trial name
- NCT00564993
- Testing
- Dobutamin
- Where
- 11 sites in Germany
- Volunteers
- 53 people
- Sponsor
- Competence Network for Congenital Heart Defects
Transposition of the Great Arteries, Systemic Right Ventricle
Systemic Right Ventricle Long-term Outcome
Patients with the transposition of great arteries (TGA) who undergo atrial switch operation and congenitally corrected TGA (ccTGA) patients have the right ventricle as their systemic ventricle.
- Trial name
- SINCERE (NCT06258083)
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 542 people
- Sponsor
- University Medical Center Groningen
Pleural Effusion, Single-ventricle
Use of Vasopressin Following the Fontan Operation
The purpose of this pilot study is to prepare for a larger study to determine whether Vasopressin following the Fontan operation will decrease chest tube output and duration.
- Trial name
- NCT02975999
- Testing
- Vasopressin, Normal Saline
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Hypoplastic Left Heart Syndrome
Near-infrared Spectroscopy (NIRS) Neurodevelopmental Outcomes
We believe that how a baby with Hypoplastic Left Heart Syndrome (HLHS)does after a major open heart operation, measured by things like blood pressure, oxygen saturation, heart rate and others, may have an impact on development.
- Trial name
- NIRS-ND (NCT00464100)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Wolff-Parkinson-White Syndrome
Physical Activity in Children With Wolff-Parkinson-White Syndrome
The aim of this study was to investigate the level of physical activity and its determinants in children with WPW.
- Trial name
- NCT06349109
- Testing
- Cardiopulmonary exercise test, Atrial-Ventricular Strain Analysis, Arterial Stiffness Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Karamanoğlu Mehmetbey University
Congenital Heart Disease, Child Development
NeuroCardio Baby Research Outpatient Clinic: Study on the Neurodevelopment of Infants With Congenital Heart Disease in Brazil
The objective of this randomized clinical trial is to test the effectiveness of a low-cost hybrid remotely monitored parent-mediated and clinic-based multidisciplinary early intervention (EI) for low-income infants with CHD in…
- Conditions
- Congenital Heart Disease, Child Development, Early Intervention
- Trial name
- NCT05907109
- Testing
- Remotely monitored parent-mediated hybrid home and clinic based multidisciplinary Early Intervention protocols.
- Where
- 2 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1
Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias
The goal of this observational study is to evaluate exercise testing and daily physical activity in children and adolescents who are diagnosed with an inherited arrhythmia.
- Conditions
- Long QT Syndrome, Catecholaminergic Polymorphic Ventricular Tachycardia Type 1, Catecholaminergic Polymorphic Ventricular Tachycardia Type 2
- Trial name
- ACTIVELY (NCT06661278)
- Testing
- Exercise tolerance test, Physical activity & heart rate monitoring
- Where
- 2 sites in United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Pulmonary Hypertension, Heart Failure
Frailty in Children With Cardiac Disease
Frailty is a complex biologic syndrome of diminished physiologic reserve that leads to decreased resistance to stressors and is associated with adverse health outcomes.
- Conditions
- Pulmonary Hypertension, Heart Failure, Single Ventricle
- Trial name
- NCT02999438
- Testing
- Actigraph to check activity levels at home
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Pediatric, Cardiac Surgery
Cardiopulmonary Circuits in the Pediatric Population
During open-heart surgery, blood flow is supported by a heart-lung machine that both pumps the blood and gives it oxygen. A problem associated with a heart-lung machine is the damage to some of the blood caused by protein in the…
- Trial name
- NCT00208728
- Testing
- PC/SMART cardiopulmonary bypass circuit, PMEA modified cardiopulmonary bypass circuit, Standard of care uncoated cardiopulmonary bypass circuit
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Emory University
Congenital Heart Disease
Nitrogen Balance in Infants After Post Cardiothoracic Surgery
The objective is to the amount of protein infants require after cardiopulmonary bypass surgery.
- Trial name
- NCT01368705
- Testing
- Standard protein delivery, Intervention 1 (2.2g/kg/day), Intervention 2 (3.0 g/kg/day)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Congenital Heart Defects, Functional Single Ventricle
Bosentan Therapy in Children With Functional Single Ventricle
Bosentan is a kind of dual endothelin receptor antagonist.The purpose of this study is to investigate if Bosentan therapy can modify the outcome of children with functional single ventricle.
- Trial name
- NCT01662037
- Testing
- Bosentan
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Patency of the Ductus Arteriosus, Acetaminophen
Prophylactic Treatment of the Ductus Arteriosus in Preterm Infants by Acetaminophen
TREOCAPA is a Phase II/III European Multicentre study concerning the prophylactic treatment by Acetaminophen of extremely preterm infant during the first five days after birth.
- Conditions
- Patency of the Ductus Arteriosus, Acetaminophen, Extreme Prematurity
- Trial name
- TREOCAPA (NCT04459117)
- Testing
- Acetaminophen, NACL 0.9%
- Where
- 36 sites in Belgium, Denmark and 10 more
- Volunteers
- 804 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.