Clinical trials: Heart Defects
Low Cardiac Output Syndrome
Levosimendan Administration in Neonates With Transposition of the Great Arteries
Calcium sensitizer drugs such as Levosimendan may exert anti-ischemic effect in addition to positive inotropic and anti-stunning effects mediated by the opening of ATP-sensitive potassium (KATP) channels.
- Trial name
- NCT01120106
- Testing
- levosimendan
- Where
- Italy
- Volunteers
- 63 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Preterm, Ductus Arteriosus
Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study
The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus…
- Trial name
- PDA (NCT06950164)
- Testing
- observation group, control group
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Congenital Heart Disease
Real-time 3-Dimensional Echocardiography for Assessment of Cardiac Function and Congenital Heart Disease
The propose of this study is to generate normative data of the tree-dimensional echocardiographic(3-DE) measurements for cardiac structure and function in a large cohort of normal infants, children,and adolescents.
- Trial name
- 3DE-CHD (NCT01300221)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Drexel University
Turner's Syndrome
Turner Syndrome: Genotype and Phenotype
This study examines the clinical and genetic factors related to Turner syndrome, a disorder of the sex chromosomes. Humans usually have 23 pairs of chromosomes-thin strands of DNA-in the nucleus of every cell, which contain genes…
- Trial name
- NCT00006334
- Where
- United States
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Patent Ductus Arteriosus
Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates
To compare the effectiveness of rectal vs. intravenous paracetamol in the medical treatment of significant PDA in neonates.
- Trial name
- NCT06256211
- Testing
- Paracetamol
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soha mahmoud Hussien mahdy
Turner Syndrome, Turner Syndrome Mosaicism, 45, X/46, XX or XY
Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome
This study plans to learn more about how the energy system works in girls with Turner syndrome. This is important to know so that the investigators understand how Turner syndrome relates to diseases such as diabetes, extra weight…
- Conditions
- Turner Syndrome, Turner Syndrome Mosaicism, 45, X/46, XX or XY, Turner Syndrome Mosaicism 46,X,I(X)(Q10)/45,X, Turner Syndrome Karyotype 46,X With Abnormal Sex Chromosome , Except I(Xq)
- Trial name
- NCT03181230
- Testing
- No intervention
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Colorado, Denver
Heart Defects, Congenital
Quantification of Cerebral Perfusion by Contrast-enhanced Ultrasound During Neonatal Heart Surgery
Transcranial contrast-enhanced ultrasound for evaluation of cerebral blood flow during pediatric cardiac surgery. This study is aimed as a feasibility study prior to conducting a lager prospective clinical trial including…
- Trial name
- TCEUS (NCT03215628)
- Testing
- TCEUS
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Congenital Cardiac Defect, Acute Renal Injury
Investigation of the Relationship Between Blood Transfusion Volume and Development of Renal Failure in Pediatric Patients Undergoing Cardiovascular Surgery
Blood transfusion strategies in cardiac surgery are a research topic that has been studied more for adults. There is not enough data on this subject for children in studies.
- Conditions
- Congenital Cardiac Defect, Acute Renal Injury, Blood Transfusion Complication
- Trial name
- NCT06889272
- Testing
- blood transfusion
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Hacettepe University
Ductus Arteriosus, Patent
Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants
The purpose of this study is to determine if adding paracetamol to ibuprofen is superior to ibuprofen only for treatment of patent ductus arteriosus (PDA) in preterm infants.
- Trial name
- NCT02002741
- Testing
- Paracetamol
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Rambam Health Care Campus
Hypoplastic Left Heart Syndrome, Hypoplastic Right-sided Heart Complex
Ambrisentan in Single Ventricle
Purpose: To evaluate the pharmacokinetics, bioavailability and hemodynamic efficacy of ambrisentan after Fontan surgical palliation of single ventricle heart defects.
- Trial name
- NCT02080637
- Testing
- Ambrisentan
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Kevin Hill
Transition to Adult Care, Congenital Heart Disease
Development and Polit Study of Get Ready With my Heart Program
The goal of this clinical trial is to learn if the Get Ready with my Heart Program developed based on SMART theory is applicable for AYAs with CHD to enhance their Transition Readiness.
- Trial name
- NCT06418373
- Testing
- Get Ready with My Heart Program, Conventional intervention
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Fudan University
Aortic Arch Hypoplasia or Atresia
Modified Perfusion for Neonatal Aortic Arch Reconstruction
Even though the lower part of the body does receive some blood supply during Cardiopulmonary Bypass(CPB) surgery, it may not be enough.
- Trial name
- NCT00490256
- Testing
- Modified Selective Cerebral Perfusion
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Congenital Heart Disease
Neurodevelopmental Disorders in Children With Congenital Heart Disease
Children with congenital heart disease are at risk for neurodevelopmental disorders, these disorders impacting their quality of life and their integration into society.
- Trial name
- NeuroDis-CHD (NCT03360370)
- Testing
- Ages & Stages Questionnaires, Third Edition in French (ASQ-3™)
- Where
- France
- Volunteers
- 233 people
- Sponsor
- University Hospital, Lille
Heart Defects, Congenital, Mental Health Issue
Mind the Heart - Mental Health in Children and Adolescents With Congenital Heart Defects
The aim of the Mind the Heart study is to document the feasibility of an online parent/child administered screening model for mental disorders (MDs) in Danish children and adolescents with congenital heart disease (CHD).
- Trial name
- Mind the Heart (NCT05709470)
- Testing
- No-intervention
- Where
- Denmark
- Volunteers
- 4,800 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Patent Ductus Arteriosus
Preliminary Percutaneous Intervention Versus Observational Trial of Arterial Ductus in Low-weight Infants
This is a pilot study to collect preliminary data for a larger, multicenter clinical trial proposal. The study will examine two strategies commonly used to treat preterm infants diagnosed with a patent ductus arteriosus (PDA).
- Trial name
- PIVOTAL (NCT03982342)
- Testing
- Cather closure of patent ductus arteriosus (PDA), Conservative management of patent ductus arteriosus (PDA)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Nationwide Children's Hospital
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Congenital Heart Disease, Mother Child Interaction
Creative Music Therapy in Newborns With Congenital Heart Disease
In the context of a clinical trial, the investigators will evaluate if parent-infant interaction can be improved by a family integrated, individualised, interactive resource- and needs-oriented music therapy approach in the dyads…
- Trial name
- BOND (NCT05702203)
- Testing
- Creative Music Therapy
- Where
- Switzerland
- Volunteers
- 164 people
- Sponsor
- University Children's Hospital, Zurich
Congenital Heart Disease
Use of High Flows in Pediatric Cardiac Surgical Patients
Humidified high flow nasal prong oxygen therapy is a method for providing oxygen and CPAP. The delivery of high flows decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the…
- Trial name
- NCT01633801
- Testing
- Use of high flows versus oxygen therapy, oxygen therapy
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Turner Syndrome, Idiopathic Short Stature
Study to Identify Markers of Insulin Resistance During Growth Hormone Treatment for Short Stature
Growth hormone treatment improves body fat distribution but also causes insulin resistance. Scientists have recently linked insulin resistance with special stores of fat in the muscles, which can be measured by magnetic resonance…
- Trial name
- NCT00121875
- Testing
- somatropin (rDNA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Congenital Heart Disease
Post-Op Massage in Infants With Congenital Heart Disease
The primary aims of the proposed study are to pilot test the effectiveness of daily massage on pain and clinical outcomes in infants who have undergone cardiothoracic surgery.
- Trial name
- NCT04416230
- Testing
- massage, quiet time
- Volunteers
- 65 people
- Sponsor
- Ohio State University
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