Clinical trials: Heart Failure, Reduced Ejection Fraction
Aortic Stenosis, Mitral Regurgitation
Evaluating Infrasonic Hemodynography
This comparative diagnostic accuracy study will determine the accuracy of a noninvasive wearable infrasonic sensor to detect the mechanical, electrical, and hemodynamic function of the cardiovascular system.
- Conditions
- Aortic Stenosis, Mitral Regurgitation, Pulmonary Hypertension, Heart Failure, Systolic
- Trial name
- NCT04636892
- Testing
- MindMics earbud
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Scripps Health
Heart Failure With Mid Range Ejection Fraction
Outcome of Discharged HFmrEF Patients
This study aimed to define the independent risk factors related cardiac events (cardiac death or heart failure-related hospitalization) among heart failure with mildly reduced ejection fraction (HFmrEF) patients who discharged…
- Trial name
- OUDI-HF (NCT05240118)
- Volunteers
- 1,693 people
- Sponsor
- Xiangtan Central Hospital
Pediatric Heart Failure
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure
This study consists of two parts (Part 1 and Part 2). The purpose of Part 1 is to evaluate the way the body absorbs, distributes, metabolizes and removes the drug LCZ696.
- Trial name
- NCT02678312
- Testing
- LCZ696, Enalapril
- Where
- 98 sites in United States, Argentina and 27 more
- Volunteers
- 393 people
- Sponsor
- Novartis Pharmaceuticals
Systolic Heart Failure
A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure
Objective The objective is to compare the efficacy of spironolactone and eplerenone on clinical outcome in patients with heart failure and a reduced ejection fraction. Method The study is a crossover cluster randomized trial.
- Trial name
- CROWD-ASPECT (NCT03984591)
- Testing
- Eplerenone, Spironolactone
- Where
- Denmark
- Volunteers
- 7,200 people
- Sponsor
- Bispebjerg Hospital
Heart Failure
BAROSTIM THERAPY™ in Heart Failure With Reduced Ejection Fraction
The purpose of this registry (NCT02880618) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO System in the commercial setting in subjects recently implanted under the CE-Marked indication for heart failure with…
- Trial name
- HFrEF (NCT02880618)
- Testing
- Barostim Neo™ System
- Where
- 30 sites in Germany, Italy
- Volunteers
- 500 people
- Sponsor
- CVRx, Inc.
Heart Failure, Systolic
Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin
The study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.
- Trial name
- NCT03553303
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Periodic Breathing
Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing
Central sleep apnoea (CSA) is common in patients with chronic systolic heart failure (HFrEF). Various trials have shown a prevalence of 21 - 37% in this group of people.
- Trial name
- NCT03532412
- Where
- Germany
- Volunteers
- 12 people
- Sponsor
- Wissenschaftliches Institut Bethanien e.V
Heart Failure With Reduced Ejection Fraction, Vitamin D Deficiency
Supplementation With Vitamin D to Patients With Heart Failure (D-Heart).
In 200 patients with documented systolic heart failure give supplementation with vitamin D in those with a 25-OH- vitamin D < 50nmol/L - or placebo.
- Trial name
- D-Heart (NCT03289637)
- Testing
- Vitamin D
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Linkoeping University
Strength Training Effects, HFrEF - Heart Failure With Reduced Ejection Fraction
Eccentric Muscle Training in Cardiac Rehabilitation
The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.
- Trial name
- NCT07636343
- Testing
- eccentric bike training, eccentric overload training, aerobic treadmill training
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- University Hospital, Antwerp