Clinical trials: Heart Failure
Duchenne Muscular Dystrophy
Wearable Technology to Evaluate Hyperglycemia and HRV in DMD - Longitudinal Aim
Duchenne Muscular Dystrophy (DMD) is an X-linked disorder that causes muscle wasting, cardiopulmonary failure, and premature death.
- Trial name
- NCT06093100
- Testing
- wearable technology
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University Medical Center
Congestive Heart Failure
Empowering Elders Through Technology
Telehomecare is a technology that individuals use in their homes to communicate with health providers electronically. This technology can help them function at a higher level and avoid undesirable hospitalizations by making…
- Trial name
- NCT00261664
- Testing
- telehomecare
- Where
- United States
- Volunteers
- 290 people
- Sponsor
- Robert Wood Johnson Foundation
Heart Failure
Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence (REBALANCE Registry)
The purpose of this registry is to develop valid scientific evidence of the safety and benefit of Barostim Therapy in the commercial setting in patients with heart failure with reduced ejection fraction (HFrEF) that were recently…
- Trial name
- NCT04502316
- Testing
- Barostim™ System
- Where
- 46 sites in United States
- Volunteers
- 435 people
- Sponsor
- CVRx, Inc.
Heart Failure, Congestive
Enhancing Caregiver Support for Heart Failure Patients: the CarePartner Study
Informal caregivers, assisted by health information technology may help to fill the gaps in VA care management of heart failure patients by enhancing support for patients' treatment adherence, behavior changes, and symptom…
- Trial name
- NCT00555360
- Testing
- HITCM+CP, HITCM only
- Where
- 2 sites in United States
- Volunteers
- 372 people
- Sponsor
- US Department of Veterans Affairs
Heart Failure, Myocardial Infarction
Echocardiographic Examination Performed by Nurses in Cardiac Intensive Care Unit
The purpose of this study is: To study the clinical usefulness of nurse-performed ultrasound and echocardiographic examinations in a cardiac intensive care unit.
- Conditions
- Heart Failure, Myocardial Infarction, Pleural Effusion
- Trial name
- NCT00886548
- Testing
- Ultrasound performed
- Where
- Norway
- Sponsor
- Helse Nord-Trøndelag HF
Heart Failure
Developing a Non-invasive Cardiac Functional Health Status Measurement Device
This is a single-center, non-randomized study.Enrolled patients will be placed on a tilt table and a stress test will be performed in a total of 4 different positions. Their blood pressure will be measured at each position.
- Trial name
- NCT01877343
- Testing
- CVInsight(TM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Florida
Heart Failure, Cardiogenic Shock
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System
There are two primary goals of this multicenter clinical trial that combines an FDA device trial and a phase II drug trial in the same study cohort. These two goals are to: 1.
- Conditions
- Heart Failure, Cardiogenic Shock, Congenital Heart Disease, Cardiomyopathies
- Trial name
- TROLLEY (NCT06080074)
- Testing
- Cardiohelp device (VA-ECMO), Heparin, Bivalirudin
- Where
- 5 sites in United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Hypertrophic Cardiomyopathy (HCM), Heart Failure
Retrospective Natural History Study of RASopathy-associated Cardiomyopathy (RAS-CM)
RASopathy-associated hypertrophic cardiomyopathy (RAS-CM) is a disease with high morbidity and high mortality if presenting during infancy.
- Conditions
- Hypertrophic Cardiomyopathy (HCM), Heart Failure, RASopathy
- Trial name
- RAS-CM (NCT07344480)
- Testing
- Retrospective data collection
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Transplant Failure, Heart Transplant Rejection
MuLtimodality EvaluatiOn of aNtibody mEdiated Damage in Heart Transplantation (LEONE-HT)
Cross-sectional evaluation of antibody mediated injury in heart transplantation patients through a multimodal approach: electron microscopy, optic microscopy, immunohistochemistry techniques, transthoracic echocardiography…
- Conditions
- Transplant Failure, Heart Transplant Rejection, Antibody-mediated Rejection
- Trial name
- LEONE-HT (NCT05184426)
- Testing
- Echocardiogram, Cardiac magnetic resonance, Coronary angiography
- Where
- 3 sites in Spain
- Volunteers
- 90 people
- Sponsor
- Juan Francisco Delgado Jimenez
Chronic Heart Failure, Atrial Fibrillation
Curing Atrial Fibrillation in Heart Failure
Heart failure is a condition that occurs when the heart muscle weakens and no longer contracts normally. Half of these patients have an irregularity of heart rhythm called atrial fibrillation (AF).
- Trial name
- NCT00292162
- Testing
- radiofrequency ablation, ACE inhibitor - ramipril, enalapril, captopril, perindopril, lisinopril, Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- NHS Greater Glasgow and Clyde
Pulmonary Edema Cardiac Cause
Cosmic Weather and Cardiogenic Pulmonary Edema
Retrospective clinical study to evaluate whether there is any correlation between the pre-hospital incidence of cardiogenic pulmonary oedema (CPE) in the selected region and the space weather parameters.
- Trial name
- NCT04483843
- Testing
- No intervention
- Where
- Czechia
- Volunteers
- 4,000 people
- Sponsor
- Emergency Medical Service of the Central Bohemian Region, Czech Republic
Heart Failure
Investigation of Transvenous Versus Epicardial Left Ventricular Stimulation Technique
The purpose of this study is to demonstrate that epicardial and transvenous left ventricular leads are safe and effective for cardiac resynchronization therapy in heart failure patients implanted with a CRT device.
- Trial name
- INTREPID (NCT00819117)
- Testing
- Cardiac Resynchronization Therapy implant
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Dilated Cardiomyopathy
Reverse Remodelling and Remission Markers in the Serial Evaluation of Recent-onset Dilated Cardiomyopathy
Approximately 30-40% of patients with non-ischaemic dilated cardiomyopathy (DCM) undergo significant left ventricular reverse remodelling in response to guideline-directed therapies.
- Trial name
- REMIT-DCM (NCT04957147)
- Testing
- 12 months of guideline-directed heart failure therapy
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Chronic Stable Heart Failure
Effects of Spironolactone on Matrix Metalloproteinases (MMPs) in Heart Failure
The purpose of this study is to evaluate the effects of spironolactone on circulating MMP levels and insulin resistance in patients with chronic heart failure.
- Trial name
- NCT00663195
- Testing
- spironolactone + furosemide
- Volunteers
- 16 people
- Sponsor
- Tottori University Hospital
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Cardiac Amyloidosis
Cardiac Amyloidosis Registry of University Hospital Leipzig
This is a clinical registry of patients with cardiac amyloidosis being treated at University Hospital Leipzig. The aim of the registry is to collect detailed information about clinical events, symptoms, imaging, biomarkers…
- Trial name
- NCT06129656
- Testing
- Routine diagnostics, Routine treatment
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Heart Failure
Repurposing Empagliflozin and Dapagliflozin for Paediatric Heart Failure: Translational Approach and Dose Rationale
This study aims at exploring the use of Dapagliflozin and Empagliflozin in children and adolescents 6-18 years old with heart failure.
- Trial name
- NCT06012266
- Testing
- Dapagliflozin tablet, Empagliflozin Tablets
- Where
- 3 sites in Switzerland, United Kingdom
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiovascular Diseases, Diabetes Mellitus
Long-Term Predictors of Morbidity in Older Age
To use existing longitudinal data from the Chicago Heart Association and Western Electric Company studies to examine adiposity in relation to heart failure, multimorbidity and to examine heart rate in relation to incident…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Heart Diseases, Heart Failure
- Trial name
- NCT00094263
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Failure
Comparison Between Internal and External Chest Impedance Measurement
To compare two methods of chest impedance: the Medtronics Optivol Measurement via CRT pacemakers for patients with heart failure and external non-invasive measurement
- Trial name
- NCT01296282
- Testing
- Medronics CRT Optivol Impedance Measurement, External Thoracic Impedance Measurement
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Cardiovascular Diseases, Heart Diseases
A Self-Management Intervention for Mild to Moderate Heart Failure
This study will test whether a self-management (SM) intervention, compared to usual care, will reduce the risk for adverse clinical outcome in patients with mild to moderate heart failure.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive
- Trial name
- HART (NCT00018005)
- Testing
- Self-Management, attention control
- Where
- United States
- Volunteers
- 902 people
- Sponsor
- Lynda Powell, PhD, MEd