Clinical trials: Helminthiasis, open to volunteers
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Trichuris Infection
Efficacy and Safety of a Single Dose of Emodepside Compared to a Single Dose of Albendazole in Adolescents and Adults Infected With Trichuris Incognita
The purpose of this clinical trial is to compare the efficacy and safety of emodepside with the standard treatment, albendazole, in adolescents (12 years and older) and adults infected with Trichuris incognita.
- Trial name
- EMOTI (NCT07258173)
- Testing
- Emodepside, Albendazole 400 mg
- Volunteers
- 100 people
- Sponsor
- Jennifer Keiser
Soil-Transmitted Helminths
Real World Evaluation of an Albendazole-Ivermectin Coformulation Safety and Effectiveness
An open-label, randomized by school, two-arm pragmatic trial, will be conducted involving two study sites in Sub-Saharan-Africa (SSA), Ghana and Kenya, to evaluate safety and effectiveness of the newly developed fixed dose…
- Trial name
- NCT06282315
- Testing
- Pre-screening Phase, Screenig Phase, Randomization
- Where
- 2 sites in Ghana, Kenya
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insud Pharma
Schistosomiasis Haematobia
Nanobody-based Schistosomiasis Urine Test Kit Research
This study aims to develop and evaluate a nanobody-based urine diagnostic test for Schistosoma haematobium infection through IPSE antigen detection.
- Trial name
- NCT07500740
- Testing
- Because this is an observational study, participants are not assigned an intervention as part of the study.
- Where
- Tanzania
- Volunteers
- 2,500 people
- Sponsor
- Pemba Ministry of Health Zanzibar
Malaria, Intestinal Worms
Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection
The purpose of this study is to evaluate, treat and follow patients with parasitic infections. People with a known or suspected parasitic infection who are at least 1 year old may be enrolled.
- Conditions
- Malaria, Intestinal Worms, GI Protozoa, Echiniococcus
- Trial name
- NCT00001645
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Immune System Diseases, Eosinophilia
Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
This study will investigate how, why and under what conditions eosinophils (a type of white blood cell) become activated and will examine their function in immune reactions.
- Conditions
- Immune System Diseases, Eosinophilia, Helminthiasis, Hypersensitivity
- Trial name
- NCT00001406
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ascariasis
Follow-up Assessment of Change in Soil-transmitted Helminths Infection Intensity in Uganda
The goal of this prospective follow-up study nested within an open-label randomized controlled trial is to investigate the unexpectedly high prevalence of Ascaris lumbricoides infection observed 3-4 months after school-based mass…
- Trial name
- FACEIT-FU (NCT07873398)
- Testing
- Albendazole 400mg, Ivermectin 3 mg
- Where
- Uganda
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Trichuriasis, Strongyloidiasis
Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras
The goal of this Phase III clinical trial is to evaluate the efficacy, safety, and acceptability of different treatment regimens for Trichuris trichiura infection in schoolchildren aged 6 to 15 years living in La Moskitia…
- Conditions
- Trichuriasis, Strongyloidiasis, Ascariasis, Hookworm Infection
- Trial name
- AIM-T (NCT07661316)
- Testing
- Albendazole 400 mg, Albendazole Plus Ivermectin, Fixed-Dose Combination Albendazole/Ivermectin (FDC)
- Where
- Honduras
- Volunteers
- 368 people
- Sponsor
- Mundo Sano Foundation
Female Genital Schistosomiasis
MATCHING - feMAle geniTal sCHistosomiasis IN miGrants Female Genital Schistosomiasis in Migrants Presenting to an Outpatient Clinic in Italy: Prevalence and Clinical Impact
The aim of this study is to evaluate the prevalence of female genital schistosomiasis (FGS) in the migrant population with gynecological problems who access our center's dedicated outpatient clinic.
- Trial name
- MATCHING (NCT07484256)
- Testing
- Cervical-vaginal swab
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Lymphatic Filariasis, Scabies
Better Options for Lymphatic Filariasis Treatment
The goal of this clinical trial is to learn if mass drug administration with moxidectin in combination with diethylcarbamazine, and albendazole (MoxDA) can treat lymphatic filariasis, scabies and strongyloidiasis in children and…
- Conditions
- Lymphatic Filariasis, Scabies, Strongyloidiasis
- Trial name
- BOLT (NCT07159373)
- Testing
- MoxDA - Moxidectin + Diethylcarbamzine (DEC) + Albendazole, IDA - Ivermectin + DEC + albendazole
- Where
- Fiji
- Volunteers
- 5,100 people, healthy volunteers welcome
- Sponsor
- Medicines Development for Global Health
Cysticercosis, Neurocysticercosis
Natural History of Treated Neurocysticercosis and Long-Term Outcomes
Neurocysticercosis is a brain disease due to the larval stage of the pork tapeworm (Taenia solium). The most common symptoms patient experience from infection inside the substance of the brain (parenchymal disease) are seizures…
- Trial name
- NCT00001205
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Echinococcosis
Collection of Biological Samples From Patients With Echinococcosis and Implementation of a Home-made PCR Method
Echinococcosis is a zoonotic disease caused by Echinococcus species. Diagnosis currently relies on imaging, serology and microscopy, but microscopy is time-consuming, has limited sensitivity and cannot distinguish between…
- Trial name
- Echino_home (NCT07715435)
- Testing
- Collection of biological samples from echinococcosis patients for the development of a home-based PCR protocol for diagnostic use.
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Schistosomiasis
Introduction of Arpraziquantel Treatment for Schistosomiasis Control in Preschool-aged Children in Endemic Areas: A Small-scale Public Health Intervention Study
The proposed small-scale pilot studies are public health intervention studies implemented through established routine programs and services in the frame of the mass drug administration (MDA) campaigns in Côte d'Ivoire, Kenya and…
- Trial name
- ADOPTpilot (NCT06698510)
- Testing
- Arpraziquantel 150mg dispersible tablet
- Where
- 7 sites in Côte d’Ivoire, Kenya and 1 more
- Volunteers
- 18,500 people, healthy volunteers welcome
- Sponsor
- Peter Steinmann
Onchocerciasis (River Blindness), Schistosomiasis
Expanding Access to Preventive Chemotherapy Among Mobile and Migrant Populations
Neglected Tropical Diseases (NTDs) are among the most common groups of diseases affecting over one billion people globally and are disproportionately concentrated in remote, underserved, and marginalized communities.
- Conditions
- Onchocerciasis (River Blindness), Schistosomiasis, Soil Transmitted Helminth (STH) Infections, Lymphatic Filariasis
- Trial name
- MISSION (NCT07707817)
- Testing
- Modified Mass Administration of Medicines Strategy, Albendazole 400 mg, Praziquantel 40 mg/kg
- Where
- Nigeria
- Volunteers
- 5,760 people, healthy volunteers welcome
- Sponsor
- Uwemedimo Friday Ekpo
Schistosomiasis
Assessment of Infection Activity in Travelers and Migrants Diagnosed With Chronic Schistosomiasis
The primary objective of this clinical investigation is to determine the percentage of travelers and migrants diagnosed with chronic schistosomiasis according to site-specific diagnostic practice who have active infection at the…
- Trial name
- SchistAct (NCT06873308)
- Testing
- UCP-LF CAA assay
- Where
- 8 sites in Belgium, Germany and 3 more
- Volunteers
- 278 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Schistosomiasis
Prevalence and Molecular Identification of Human Schistosomiasis
Schistosomiasis remains one of the most important parasitic diseases of public health concern, particularly in developing countries including Egypt. It is caused by a trematode worm (blood flukes) of the genus Schistosoma
- Trial name
- NCT07482215
- Testing
- Molecular phylogenetic and haplotype analysis
- Volunteers
- 359 people
- Sponsor
- Assiut University
Dengue, Chikungunya
Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective
RACSMEI addresses the high burden of infectious diseases in low- and middle-income countries, including Cambodia, where limited surveillance and laboratory capacity often obscure etiologies and transmission dynamics.
- Conditions
- Dengue, Chikungunya, Zika Virus Infection, Japanese Encephalitis
- Trial name
- RACSMEI (NCT07358910)
- Where
- Cambodia
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur du Cambodge
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Siargao (NCT06800248)
- Testing
- emodepside (BAY 44-4400), Mebendazole 100 MG
- Where
- Philippines
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Soil Transmitted Helminth (STH) Infections
Assessing the Safety and Efficacy of a Combination Therapy for STH in PSAC in Bangladesh
Background (brief): 1. Burden: Soil-transmitted helminth (STH) infections are a major public health problem, primarily affecting children.
- Trial name
- NCT07045493
- Testing
- A single dose of Albendazole 400mg + Ivermectin (200 µg/ kg) combination therapy, A single dose of 400 mg Oral Albendazole monotherapy
- Where
- Bangladesh
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh