Clinical trials: Hemoglobin
Anemia
Effect of Maternal Hemoglobin on Neurobehavioural Development of Late Preterm Neonates : A Cohort Study
The study entitled 'Effect of maternal hemoglobin on neurobehavioral development of late preterm neonates' was done with an objective to determine whether low maternal hemoglobin (<11gm/dl), in late preterm neonates(>34weeks but…
- Trial name
- NCT02840292
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Lady Hardinge Medical College
Surgery
Preoperative Noninvasive Hemoglobin Monitoring in Pediatric Patients
The preoperative evaluation including sampling blood in pediatric patients is hard to perform. However, the knowledge of the baseline cell blood count is important to prepare unexpected surgical bleeding etc..
- Trial name
- NCT02484365
- Testing
- No treatment
- Where
- South Korea
- Volunteers
- 177 people
- Sponsor
- Chung-Ang University Hospital
Acute Pancreatitis
Relation of Glucose and Acute Pancreatitis
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients.
- Trial name
- ROGAAP (NCT01470885)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Huashan Hospital
Athletes, Iron
Oslo Footballplayers Iron Supplementation and Training (FIT) Study
The aim of the study is to characterize the diet and iron status of young female elite football players and examine the relationship between iron intake, iron status, hemoglobin levels, intestinal health and sports performance.
- Conditions
- Athletes, Iron, Endurance Performance, Hemoglobin
- Trial name
- Oslo-FIT (NCT04526678)
- Testing
- Iron supplement (27mg)
- Where
- Norway
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Life Sciences
Transfusion Related Complications
Clinical Trial of West-China Perioperative Transfusion Score (WCPTS）for Massive Hemorrhagic Surgery
Guidelines for blood transfusion have been issued for years. According to these guidelines, red blood cells (RBCs) transfusion should be given when the hemoglobin level is less than 6g/dL or 7g/dL and is unnecessary when the…
- Trial name
- WCPTS (NCT01345643)
- Testing
- Maintenance of hemoglobin level not less than 10g/dL, Transfusion trigger based on WCPTS
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Ren Liao
Hematologic Malignancy, Acute Leukemia
MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies
This is a phase II, open-label, prospective study of T cell receptor alpha/beta depletion (TCR α/β TCD) peripheral blood stem cell (PBSC) transplantation for children and adults with hematological malignancies.
- Conditions
- Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia
- Trial name
- NCT05735717
- Testing
- Fludarabine, Busulfan, Melphalan
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Sickle Cell Disease
A Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell Disease (GRASP, BMT CTN 2001)
A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine in which genetic material (mostly DNA) in the patient is changed to treat his or her own…
- Trial name
- GRASP (NCT05353647)
- Testing
- Autologous CD34+ HSC cells transduced with the lentiviral vector containing a shRNA targeting BCL11a
- Where
- 9 sites in United States
- Volunteers
- 25 people
- Sponsor
- David Williams
Sickle Cell Disease, Sickle B+ Thalassemia
The Longitudinal Relationship of HU Adherence to HRQOL, Barriers to Adherence and Habit in SCD.
The primary objective of this study is to better understand factors contributing to variations in hydroxyurea (HU) adherence behavior in adolescents and young adults (AYA) with sickle cell disease (SCD).
- Conditions
- Sickle Cell Disease, Sickle B+ Thalassemia, Sickle Beta Zero Thalassemia, Sickle Cell Hemoglobin C
- Trial name
- NCT04691323
- Testing
- HU-Go app
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Impaired Oxygen Delivery, Congenital Heart Disease
Restrictive Versus Liberal Transfusion Protocol in Infants Undergoing Cardiac Surgery
In neonates and infants </= 10 kg following cardiac surgery for congenital heart disease a more restrictive red blood cell (RBC) transfusion strategy will be as effective as, and possibly superior to, a liberal RBC strategy.
- Trial name
- NCT01484886
- Testing
- Red blood cell transfusion
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Hemoglobin, Stem Cell Transplant
Fertility Preservation in Women Who Will Have Gonadotoxic Therapy or Hematopoetic Stem Cell Transplantation, and in Women With Sickle Cell Disease
Background: Some treatments for cancer or other diseases can lead to infertility in women. These treatments include chemotherapy, some stem cell transplants, and pelvic radiotherapy. They are called gonadotoxic therapies.
- Conditions
- Hemoglobin, Stem Cell Transplant, Aplastic Anemia
- Trial name
- NCT02225145
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Beta Thalassemia, Hemoglobinopathy
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)
This 12-month study will evaluate the safety and effectiveness of hydroxyurea in treating beta-thalassemia, a type of anemia caused by defective hemoglobin (the oxygen-carrying pigment in blood).
- Trial name
- NCT00001958
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 2 Diabetes, Hyperglycemia Due to Type 2 Diabetes Mellitus
CGM Use in Children With Type 2 Diabetes
The purpose of this prospective study is to determine if trial use of a Dexcom G6 CGM system for a 10 day wear period in pediatric Type 2 diabetes patients improves short term time in range glucose control and 3-6 month glycemic…
- Trial name
- IMPaCT2 (NCT04721158)
- Testing
- Continuous glucose monitor
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Johns Hopkins University
Gastroschisis, Intestinal Ischemia
Regional Blood Saturation Levels in Gastroschisis
Gastroschisis is one of the most common neonatal surgical conditions, and is increasing in incidence. Postnatal bowel ischemia leading to necrosis, bowel loss and short-bowel syndrome, occurs in a few instances, with significant…
- Trial name
- NCT03533439
- Testing
- Near infrared spectroscopy
- Volunteers
- 19 people
- Sponsor
- NHS Lothian
Fetal Hemoglobin, Beta-Thalassemia
Long Term Beta Thalassemia Treatment: Findings From The Extension Period
The project, titled "Long Term Beta Thalassemia Treatment: Findings From The Extension Period Of Phase 2 Clinical Trial," aims to compare the efficacy and safety of combination therapy (thalidomide and hydroxyurea) versus…
- Conditions
- Fetal Hemoglobin, Beta-Thalassemia, Hemoglobinopathies
- Trial name
- Thalidomide (NCT06490601)
- Testing
- thalidomide and hydroxyurea, Thalidomide
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
Preterm Birth, Oxygen Toxicity
Fetal Haemoglobin and Cerebral and Peripheral Oxygenation.
The aim of this study is to investigate the relationship between cerebral and peripheral oxygenation and oxygen extraction, as measured by NIRS (near-infrared spectroscopy ), and the FHbF (fraction of fetal hemoglobin) and…
- Conditions
- Preterm Birth, Oxygen Toxicity, Fetal Hemoglobin
- Trial name
- HbFIN (NCT04802629)
- Testing
- Near-infrared spectroscopy
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Iron Deficiency Anemia
Effect of Rice Fortification With Iron on Anemia Among Children
This was a double-blind community-based trial, placebo controlled. During 16 weeks, children in the intervention group (GI, n=180) received iron fortified rice, and children in the control group (GC, n=174) received rice with…
- Trial name
- NCT00727545
- Testing
- iron bisglycine chelate
- Where
- Brazil
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Malnutrition, Child, Malnutrition, Infant
Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)
A 1:1:1 individually randomized unmasked controlled trial is proposed in which caregivers will be trained to screen their children who have recovered from an episode of SAM (severe acute malnutrition) using MUAC (mid-upper arm…
- Conditions
- Malnutrition, Child, Malnutrition, Infant, Malnutrition or Risk of Malnutrition, Hemoglobin Level Measurement
- Trial name
- MAMAN (NCT06599580)
- Testing
- Training caregivers to screen children for malnutrition relapse, Reduced follow-up schedule
- Where
- Burkina Faso
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Ulcerative Colitis, Crohn's Disease
Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate
Iron deficiency anaemia is common in inflammatory bowel disease (IBD), affecting at least 20% patients at any one time. Hepcidin, a recently described anti-microbial peptide synthesized by the liver, is a key regulator of iron…
- Trial name
- NCT01991314
- Testing
- Ferrous sulphate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Queen Mary University of London
Sickle Cell Disease
A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of…
- Trial name
- HIBISCUS (NCT04624659)
- Testing
- Etavopivat Tablets Low dose, Etavopivat Tablets High dose, Etavopivat Tablets
- Where
- 142 sites in United States, Canada and 15 more
- Volunteers
- 450 people
- Sponsor
- Forma Therapeutics, Inc.