Clinical trials: Hepatic
Acute on Chronic Liver Failure
Granulocyte Colony Stimulating Factor(G-CSF) Therapy for Patients With ACLF
The purpose of the study is to determine whether Granulocyte Colony Stimulating factor(G-CSF) therapy is effective in the treatment of patients with Acute on chronic liver failure(ACLF).
- Trial name
- NCT01036932
- Testing
- Granulocyte Colony Stimulating Factor, Normal Saline
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Govind Ballabh Pant Hospital
Hepatic Encephalopathy
PEG (Polyethylene Glycol)Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy
The current standard of care for patients with HE includes non-absorbable disaccharides(lactulose);The chemical name for lactulose is 4-O-β-D-galactopyranosyl-D-fructofuranose.The exact mode of action by lactulose is thought to…
- Trial name
- NCT03100513
- Testing
- Lactulose, Polyethylene Glycol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sherief Abd-Elsalam
Cholangiocarcinoma
Evaluation of Combined Modality Protons and Hepatic Transplantation for Hilar Cholangiocarcinoma
Proton Beam Therapy (PBT) is an advanced radiotherapy technique. There are two National Health Service (NHS) PBT treatment centres in the United Kingdom (UK), in Manchester and London.
- Trial name
- EMPHATIC (NCT06434493)
- Testing
- Proton Beam Therapy, Concurrent oral capecitabine chemotherapy, Cisplatin & Gemcitabine intravenous chemotherapy
- Volunteers
- 30 people
- Sponsor
- The Christie NHS Foundation Trust
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Type 2, Obesity
Effect of Roux-en-Y Gastric Bypass or Gastric Sleeve Surgery on Type 2 Diabetes
Roux-en-Y Gastric Bypass surgery (RYGB) ameliorates type 2 diabetes within days after surgery. Studies indicate that the gastric sleeve procedure has comparable effect on type 2 diabetes, but to what extent and how is not fully…
- Trial name
- NCT02713555
- Testing
- Roux-en-Y Gastric Bypass, Gastric Sleeve
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cystic Fibrosis, Cystic Fibrosis-related Diabetes
Glycemic Characterization and Pancreatic Imaging Correlates in Cystic Fibrosis
The purpose of this study is to investigate the utility of a continuous glucose monitor device (CGM) in screening for cystic fibrosis related diabetes.
- Conditions
- Cystic Fibrosis, Cystic Fibrosis-related Diabetes, Cystic Fibrosis Liver Disease, Pancreatic Steatosis
- Trial name
- CFCGM (NCT03961516)
- Testing
- Frequently Sampled Oral Glucose Tolerance Test and CGM, MRI Pancreas and Liver
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Acute-On-Chronic Liver Failure
Acute on Chronic Liver Failure in Cirrhotic Patients at Assiut University Hospitals
ACLF is a distinct syndrome that is different from chronic progressive hepatic decompensation. In most cases of ACLF, patients present initially with clinical manifestations of a decompensating event, usually renal impairment…
- Trial name
- NCT06142968
- Testing
- laboratory tests
- Volunteers
- 96 people
- Sponsor
- Assiut University
Hepatic Artery Thrombosis, Hepatic Artery Stenosis
Hepatic Artery Stenosis and Thrombosis After Liver Transplantation in Children
The goal of this observational study is to investigate the incidence, current management practices, and outcomes in pediatric patients with HAC after liver transplantation.
- Conditions
- Hepatic Artery Thrombosis, Hepatic Artery Stenosis, Pediatric ALL, Liver Transplant; Complications
- Trial name
- HEPATIC (NCT05818644)
- Where
- Netherlands
- Volunteers
- 583 people
- Sponsor
- University Medical Center Groningen
Liver Cirrhosis
Sleep Timing and Circadian Preferences in A Sample of Egyptian Patients With Hepatic Cirrhosis
Individuals with hepatic cirrhosis (n=50) and healthy controls (n=30) were recruited. Sleep quality, sleep timing parameters and circadian preference were evaluated using the Pittsburgh Sleep Quality Index (PSQI), Sleep Timing…
- Trial name
- NCT02710227
- Testing
- (PSQI), (STQ).
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sherief Abd-Elsalam
Impaired Hepatic Function, Healthy
Study of ALXN2050 in Participants With Hepatic Impairment
This study will investigate the impact of impaired hepatic function (IHF) on the plasma pharmacokinetics of ALXN2050 in order to provide dosing recommendations for future indications in individuals with varying degrees of IHF.
- Trial name
- NCT05259085
- Testing
- ALXN2050
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Cystic Fibrosis
Outcomes in CF Patients Accessing Their Registry Health Records
A multifactorial, parallel group, randomised control study in cystic fibrosis (CF) patients aged 13-30 years over an 18 month period.
- Trial name
- CFView (NCT03434886)
- Testing
- CFView, CF educational videos
- Volunteers
- 282 people
- Sponsor
- Cystic Fibrosis Registry of Ireland
Transplantation
Vaccines Immunogenicity in Renal, Hepatic, Cardiac or Pulmonary Transplanted Children
Thanks to improved surgical techniques, postoperative management and immunosuppressive therapies, an increasing number of children benefit from renal, hepatic, cardiac and pulmonary transplantation.
- Trial name
- COVAGREF (NCT03180359)
- Testing
- Recommended vaccine scheme according to French Vaccine Schedule 2015
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hospices Civils de Lyon
Acute Liver Failure
Clinical Study of Pediatric Acute Liver Failure
The goal of this observational study is to understand the etiology, prognosis and influencing factors of acute liver failure in children, evaluate the predictive value of children's SOFA score, PELD score and LIU score for the…
- Trial name
- NCT06893042
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Fansen Zeng
Portal Hypertension
Doppler Ultrasound Hepatic Vein Waveform as a Non-invasive Tool in the Assessment of Severity of Portal Hypertension
Portal hypertension is the result of an increased hepatic vascular resistance and portal inflow. The best established method to assess portal pressures is the determination of wedged hepatic venous pressure gradient (HVPG).
- Trial name
- DPH (NCT02975323)
- Testing
- Carvedilol
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Aga Khan University
to Find Out Non-invasive Indices to Predict the Status of Hepatic Fibrosis in BA Patients.
the Correlation Between Non-invasive Indicators in Patients With Biliary Atresia
we propose this study and try to find out possible clinical applicable non-invasive imaging indices or its combination with the laboratory indices to predict the status of hepatic fibrosis in BA patients.
- Trial name
- NCT02848573
- Volunteers
- 41 people
- Sponsor
- National Taiwan University Hospital
Biliary Atresia
Biliary Atresia, Hepatic Buffer Response and Sevoflurane
To evaluate the effects of sevoflurane on hepatic blood flow (HBF) and hepatic arterial buffer response (HABR) in infants with obstructive jaundice by Doppler ultrasound.Twenty-five infants with biliary atresia (1-3…
- Trial name
- NCT02471209
- Testing
- Sevoflurane
- Volunteers
- 25 people
- Sponsor
- Children's Hospital of Fudan University
Lymphoblastic Leukemia, Acute, Childhood
Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL
High-dose methotrexate therapy (HDMTX) is an important part of treatment of childhood acute lymphoblastic leukemia (ALL). HDMTX would be improved substantially if it were possible to predict the clearance of MTX for each patient…
- Trial name
- NCT01896752
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Ovarian Syndrome, Obesity
Oral Amino Acid Nutrition to Improve Glucose Excursions in PCOS
The Investigators will measure hepatic glucose and fat metabolism in obese girls with Polycystic Ovarian Syndrome (PCOS) and hepatic steatosis (HS) after taking 4 weeks of an essential amino acid (EAA) supplement or placebo and…
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- ORANGE (NCT03717935)
- Testing
- Essential Amino Acid (EAA) Supplement
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Colorado, Denver
Cystic Fibrosis
Comparison of Non-invasive Measurement Methods of Hepatic Fibrosis in Cystic Fibrosis
Non-invasive methods of the quantification of fibrosis may help to assess the development of fibrosis at a specific moment of the evolution of the disease, in the order to decide the initiation of treatment with ursodeoxycholic…
- Trial name
- MUCO-FIBRO (NCT02342964)
- Testing
- Measure of hepatic elasticity
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Polycystic Ovarian Syndrome, Obesity
Post-Prandial Liver Glucose Metabolism in PCOS
The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.
- Conditions
- Polycystic Ovarian Syndrome, Obesity, Hepatic Steatosis
- Trial name
- PLUM (NCT03041129)
- Testing
- oral glucose tolerance test, MRI of liver
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver