Clinical trials: Hepatic Failure
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Liver Failure, Small-for-Size Syndrome
Safety and Tolerability Study of a Novel Bioartificial Liver in Liver Failure and Small-for-Size Syndrome
The goal of this clinical trial is to evaluate the safety and tolerability of a novel bioartificial liver (CiPS-BAL) in patients with liver failure or small-for-size syndrome.
- Trial name
- NCT07312864
- Testing
- Chemically induced pluripotent stem cells biological Artificial Liver
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Beijing Friendship Hospital
Acute on Chronic Liver Failure, Traditional Chinese Medicine
Study on the Optimal Strategy for Acute-on-chronic Liver Failure With Integrative Treatment
Background: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute deterioration in the setting of chronic liver disease associated with high short-term mortality.
- Conditions
- Acute on Chronic Liver Failure, Traditional Chinese Medicine, Hepatitis B
- Trial name
- NCT03577938
- Testing
- Chinese herbal medicine, Control (blank)
- Where
- 15 sites in China
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Beijing 302 Hospital
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Acute-On-Chronic Liver Failure
Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRT
ACLF and cirrhotic patient have deranged coagulation parameters and this coagulation parameters altered when this group of patients undergoing dialysis because of renal failure. this group of patients is also high risk of sepsis.
- Trial name
- NCT04960163
- Testing
- No intervention
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acetaminophen, Drug Overdose
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
This study is a randomized, placebo-controlled double-blinded clinical trial of patients presenting with acetaminophen poisoning who are at increased risk of developing liver injury.
- Conditions
- Acetaminophen, Drug Overdose, Acetaminophen Overdose, Acetaminophen Poisoning
- Trial name
- NCT05517668
- Testing
- Intravenous infusion of N-acetylcysteine, Intravenous infusion of Fomepizole (4-MP)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Richard Dart, MD, PhD
Hepatic Encephalopathy, Minimal Brain Dysfunction
Minimal Hepatic Encephalopathy in Hereditary Hemorrhagic Telangiectasian
HHT or Rendu-Osler-Weber disease is a genetic disease with an autosomal dominant inheritance pattern, characterized by widespread telangiectases that can involve several organs including the intestinal tract and the liver.
- Trial name
- mHE-HHT (NCT03586115)
- Testing
- Critical flicker frequency assessment
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Bari
Liver Failure
The Relationship of Initial Liver Profile and Outcome After Transplantation
Donation after cardiac death (DCD) livers are increasingly utilised in liver transplantation but concerns exist regarding negative results.
- Trial name
- NCT02307890
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Acute Liver Failure, Mitochondrial Diseases
Longitudinal Study of Mitochondrial Hepatopathies
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating…
- Conditions
- Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial
- Trial name
- MITOHEP (NCT01148550)
- Where
- 16 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Arbor Research Collaborative for Health
Liver Failure, Kidney Failure
NIRS as a Continuous Noninvasive Monitoring System of Liver/Kidney Graft Perfusion
The aim of the investigators work is to describe the agreement between NIRS and ecodoppler, as monitoring systems of liver and kidney graft's perfusion in the immediate postoperative period in pediatric patients.
- Trial name
- NIRS (NCT02343016)
- Testing
- Near-InfraRed Spectroscopy (NIRS)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Mariella Enoc
Liver Cirrhosis
Probiotics for the Prevention of Major Complications of Cirrhosis
The purpose of this study is to determine whether probiotics are effective in the prevention of the complications of liver cirrhosis.
- Trial name
- NCT00312910
- Testing
- Probiotics-Bio-plus
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Chronic Liver Failure
Aerobic Capacity Muscle Strength and Health Related Quality of Life in Children With Chronic Liver Disease
Physical therapy program for children with chronic liver disease consist of gait training, strengthening ex for UL\&ll, stretching exercise to improve physical fitness and quality of life
- Trial name
- NCT06240832
- Testing
- Physical therapy exercise
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University
Liver Failure, Hepatitis B
RCT Study on Granulocyte Colony-stimulating Factor(G-CSF) Treatment of Hepatic Failure
This study evaluates the Granulocyte colony-stimulating factor (G-CSF) in the treatment of Acute on Chronic Liver Failure in adult.
- Conditions
- Liver Failure, Hepatitis B, Alcoholic Liver Disease
- Trial name
- NCT02331745
- Testing
- Granulocyte colony-stimulating factor, standard treatment
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing 302 Hospital
Short Bowel Syndrome, Intestinal Failure
Can SMOFlipid®, A Composite Parenteral Nutrition Lipid Emulsion, Prevent Progression Of Parenteral Nutrition Associated Liver Disease In Infants?
The aim of this study is to determine the feasibility of conducting a trial to examine the efficacy of an ω3FA (Omega-3 fatty acid) containing balanced lipid emulsion in the prevention of progression of PNALD in infants with…
- Conditions
- Short Bowel Syndrome, Intestinal Failure, Gastrointestinal Motility Disorder, Mucosal Enteropathy
- Trial name
- NCT00793195
- Testing
- Intralipid 20%, SMOFlipid 20%
- Where
- 5 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
End Stage Liver Disease, Infection
A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study)
The term of End Stage of Liver Disease (ESLD) was raised in 80's of 20 Century, but without a restrict definition. Infections are the cause and effect in occurrence and development of ESLD, which not only induce or exacerbate…
- Trial name
- NCT03363451
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Cirrhosis
Study Of Bacterial/Fungal Infections in Hospitalized Patients With Liver Cirrhosis in China
This is a national, investigator-initiated, multicenter, prospective, observational, web-based registry in hospitalized patients with cirrhosis across China.
- Trial name
- SONIC (NCT03676777)
- Where
- 23 sites in China
- Volunteers
- 1,232 people
- Sponsor
- Ruijin Hospital
Acute Liver Failure
Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure
Acute liver failure is a multisystem disorder characterized by a syndrome of jaundice, coagulopathy, and encephalopathy with high mortality in the absence of liver transplantation.
- Trial name
- NCT06831643
- Testing
- Standard Medical treatment, Therapeutic Plasma Excahnge
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure, Acute on Chronic, Liver Dysfunction
A Validation Cohort for ACLF Diagnosis and Prognosis
Acute on chronic liver failure (ACLF) is a distinct entity encompassing the acute deterioration of liver function, culminating in multiple organs failure and high short-term mortality.
- Trial name
- Ch-CANONIC-Val (NCT03641872)
- Testing
- Standary therapy
- Where
- 12 sites in China
- Volunteers
- 1,370 people
- Sponsor
- Hai Li
Acute Liver Failure, Acute Liver Injury
Biomarkers in Liver Failure
Acute liver injury (ALI) and acute liver failure (ALF) are rare clinical conditions, the latter often associated with a poor outcome.
- Conditions
- Acute Liver Failure, Acute Liver Injury, Acute on Chronic Hepatic Failure
- Trial name
- NCT02833064
- Testing
- Non-contrast magnetic resonance imaging, Biological sampling
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Ventilation, ARDS
Respiratory Knowledge Portal Computer and Phone Application to Improve Quality of Mechanical Ventilation by Reducing the Number of Ventilator Associated Events, Injury Created by the Ventilator and Unsafe Setting of Alarms.
Ventilator associated events (VAE) is a quality metric defined by 48 hours of stability followed by 48 hours of escalation of ventilator settings within the ICU.
- Conditions
- Ventilation, ARDS, Respiratory Failure, Mechanical Ventilation
- Trial name
- NCT06737432
- Testing
- RKP Monitoring Software
- Where
- United States
- Volunteers
- 875 people
- Sponsor
- The University of Texas Medical Branch, Galveston