Clinical trials: Hepatic Impairment
Impaired Hepatic Function, Healthy
Study of ALXN2050 in Participants With Hepatic Impairment
This study will investigate the impact of impaired hepatic function (IHF) on the plasma pharmacokinetics of ALXN2050 in order to provide dosing recommendations for future indications in individuals with varying degrees of IHF.
- Trial name
- NCT05259085
- Testing
- ALXN2050
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Dementia, Cognitive Decline
Ammonia Levels and Cognitive Impairment
The purpose and objective of this study is to determine the prevalence of elevated ammonia levels in subjects with cognitive impairment, and to observe if treating the cause of the elevated ammonia level improves mental status.
- Conditions
- Dementia, Cognitive Decline, Cognitive Impairment, Developmental Delay
- Trial name
- NCT02059356
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Hepatic Impairment
Pharmacokinetics of LCQ908 in Patients With Hepatic Impairment
This study will compare the pharmacokinetics of LCQ908 in subjects with varying degrees of hepatic impairment to healthy subjects.
- Trial name
- NCT01594957
- Testing
- LCQ908
- Where
- 2 sites in United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
A Study of Equfina® on the Incidences of Adverse Drug Reactions in Participants With Parkinson's Disease (Including Participants With Hepatic Impairment)
The purpose of the study is to investigate the incidences of psychiatric symptoms (example, hallucinations), somnolence and sudden onset of sleep, dyskinesia, and retinal degeneration-related events during treatment with Equfina…
- Trial name
- NCT04724109
- Testing
- Equfina
- Where
- 2 sites in Japan
- Volunteers
- 1,088 people
- Sponsor
- Eisai Co., Ltd.
Liver Disease, Impaired Liver Function
Compassionate Use of Omegaven in the Treatment of Parenteral Nutrition Induced Hepatic Injury
This study is being done to determine if an investigational study drug called Omegaven can help to improve liver disease thought to be caused by Total Parenteral Nutrition (TPN).
- Conditions
- Liver Disease, Impaired Liver Function, Parenteral Nutrition Associated Liver Disease
- Trial name
- NCT02010034
- Testing
- Omegaven
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Children's Medical Center Dallas
Type 2 Diabetes Mellitus
Specified Drug-Use Survey of Alogliptin and Metformin Hydrochloride Combination Tablets "Survey on Long-term Use in Type 2 Diabetes Mellitus Patients With Renal or Hepatic Impairment or Advanced Age"
The purpose of this survey is to evaluate the long-term safety and efficacy of the alogliptin and metformin hydrochloride combination tablet in type 2 diabetes mellitus patients with renal impairment (mild), hepatic impairment…
- Trial name
- NCT03555565
- Testing
- Alogliptin and Metformin hydrochloride
- Where
- Japan
- Volunteers
- 1,026 people
- Sponsor
- Takeda
Rupture, Spontaneous, Rupture Liver
A Comparison Between Child-Pugh and Albumin-Bilirubin Scores
To compare Child-Pugh and Albumin-Bilirubin scores in patients with spontaneous rupture of hepatocellular carcinoma
- Conditions
- Rupture, Spontaneous, Rupture Liver, Hepatocellular Carcinoma, Hepatic Impairment
- Trial name
- NCT03534843
- Testing
- Liver resection, Transcatheter arterial embolization
- Volunteers
- 230 people
- Sponsor
- Huazhong University of Science and Technology