Clinical trials: Histamine
Urticaria
An Efficacy and Safety Study of Desloratadine (MK-4117) in Japanese Participants With Chronic Urticaria (MK-4117-201)
This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with chronic urticaria. The primary hypothesis is that the efficacy of desloratadine 10 mg and 5 mg is superior to placebo as…
- Trial name
- NCT01916967
- Testing
- Desloratadine
- Volunteers
- 239 people
- Sponsor
- Organon and Co
Chronic Urticaria
Real-world Evaluation of the Effectiveness of Immunoglobulin-Histamine Complex, IHC (Histoglob) in Chronic Urticaria
This is a prospective, multicentre, non-interventional, observational, real-world evidence (RWE) study designed to evaluate the effectiveness and safety of Immunoglobulin/Histamine Complex (IHC) in patients with Chronic Urticaria…
- Trial name
- RUSH (NCT07680413)
- Testing
- Antihistaminics, H2 blockers, Leukotriene antagonists, Immunoglobulin/Histamine Complex (IHC) Injection
- Where
- 40 sites in India
- Volunteers
- 660 people
- Sponsor
- Bharat Serums and Vaccines Limited
Diet Modification, Chronic Urticaria
Dietary Treatment for Chronic Urticaria
Histamine is a biologically active component that can be found in many foods and beverages. Intake of excessive histamine from foods or beverages, can trigger symptoms including urticaria.
- Trial name
- DTCU (NCT02047136)
- Testing
- Treatment group (on low histamine diet), Well-balanced diet
- Where
- China
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Hong Kong Sanatorium & Hospital
Perennial Allergic Rhinitis
A Confirmatory Study of TAU-284 in Pediatric Patients With Perennial Allergic Rhinitis
The objectives of this study are: to confirm the superiority of TAU-284 over placebo after two weeks of administration to pediatric patients with perennial allergic rhinitis, and to investigate the dose response, safety, and…
- Trial name
- NCT01425632
- Testing
- TAU-284
- Where
- 5 sites in Japan
- Volunteers
- 490 people
- Sponsor
- Tanabe Pharma Corporation
Asthma
The Effect of Xolair (Omalizumab) on Allergy Blood Cells
We are studying Xolair (omalizumab) to see it's effect on allergic blood cells. The blood tests will be done in a test tube to see if they react differently before and after treatment.
- Trial name
- NCT00657891
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Creighton University
Sickle Cell Disease
Interest of Famotidine in Children With Sickle Cell Disease
The purpose of this study is to determine whether oral famotidine, a histamine type 2 receptor antagonist already widely used with very few side effects in other indications in children, is effective in reducing endothelial…
- Trial name
- FAMODREP (NCT05084521)
- Testing
- Famotidine 400 mg/50 mL
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dermatitis, Atopic
Histamine Pharmacogenetics in Children With Atopic Dermatitis
The primary goal of the study is to investigate the impact of a common genetic polymorphism in a histamine detoxification enzyme that may well have a common role in regulating the expression of atopic dermatitis (AD) and other…
- Trial name
- NCT00277433
- Testing
- Buccal Swab
- Where
- 7 sites in United States
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Perennial Allergic Rhinitis
The Confirmatory Study of TAU-284 in Pediatric Patients With Perennial Allergic Rhinitis
The objectives of this study are: to confirm the superiority of TAU-284 over placebo after two weeks of administration to pediatric patients with perennial allergic rhinitis and to investigate safety of TAU-284.
- Trial name
- NCT01861522
- Testing
- Bepotastine besilate
- Where
- 2 sites in Japan
- Volunteers
- 473 people
- Sponsor
- Tanabe Pharma Corporation
Histamine Biotransformation
In Vivo Assessment of Histamine Pharmacodynamics
A critical first step to address the "pharmacodynamic information gap" in pediatrics resides with the development of methods capable of accurately measuring the time dependent effects of xenobiotic exposure in a manner sufficient…
- Trial name
- NCT00809692
- Testing
- validated techniques for histamine response, new technique for histamine response
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Allergic Asthma, Allergic Rhinitis
Effect of Montelukast on Basophils, In-vitro
Subjects with either allergic asthma or allergic rhinitis will be recruited to obtain blood. This blood will be used to be stimulated with to whatever the patient allergic.
- Trial name
- NCT00710450
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Creighton University
Bipolar Disorder, Pediatric
Efficacy and Safety of Asenapine Treatment for Pediatric Bipolar Disorder (P06107 Has an Extension [P05898; NCT01349907])(P06107)
Efficacy and safety of asenapine for the treatment of bipolar I disorder (manic or mixed episodes) will be evaluated in participants between 10 and 17 years old, who are either hospitalized or non-hospitalized.
- Trial name
- NCT01244815
- Testing
- asenapine, Rescue medication
- Volunteers
- 404 people
- Sponsor
- Organon and Co
Seasonal Allergic Conjunctivitis
Ketotifen Ophthalmic Solution With Emedastine in Patients With Seasonal Allergic Conjunctivitis
Medications available for the treatment of seasonal allergic conjunctivitis include antihistamines. These medicines block the release of histamine, a substance in the body that is released when an allergic reaction occurs.
- Trial name
- NCT00133627
- Testing
- Ketotifen
- Where
- China
- Volunteers
- 229 people
- Sponsor
- Novartis
Allergic Asthma
A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma (HAS3)
This is a randomized, double-blind, placebo-controlled, crossover study comparing asthma control post treatment in African American/Black and Caucasian/White children in both hyper and hypo responsive HILD (Histamine…
- Trial name
- HAS3 (NCT04699604)
- Testing
- Levocetirizine Dihydrochloride
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Bridgette Jones
Urticaria Chronic
Mediterranean and Low-Histamine Diets for Pediatric Chronic Spontaneous Urticaria
Chronic spontaneous urticaria (CSU) is a chronic inflammatory skin disease that can substantially impair quality of life in children and adolescents.
- Trial name
- NCT07765979
- Testing
- Low-Histamine Diet, Mediterranean Diet
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- Saglik Bilimleri Universitesi
Pediatric Chronic Spontaneous Urticaria
Pseudoallergen-Free and Low-Histamine Diet in Adolescents With Chronic Spontaneous Urticaria
The goal of this clinical trial is to learn whether a histamine- and pseudoallergen-restricted diet can help reduce symptoms in people with chronic urticaria.
- Trial name
- PAF-LH-CSU (NCT07632040)
- Testing
- Intervention Name: Low-histamine and pseudoallergen-free diet, General healthy eating advice
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul University
Perennial Allergic Rhinitis
A Study of the Efficacy and Safety of Desloratadine (MK-4117) in Japanese Participants With Perennial Allergic Rhinitis (MK-4117-200)
This is a study to evaluate the efficacy and safety of desloratadine (MK-4117) in Japanese participants with perennial allergic rhinitis.
- Trial name
- NCT01918033
- Testing
- Desloratadine 5 mg
- Volunteers
- 608 people
- Sponsor
- Organon and Co
Rhinitis, Allergic, Perennial
Cetirizine Placebo Controlled Study For Perennial Allergic Rhinitis
Study objective is to verify the superiority of CTZ DS to the placebo groups in the change of total nasal symptom score (TNSS) over the total treatment period from the score of the baseline assessment period.
- Trial name
- NCT00490204
- Testing
- Cetirizine
- Where
- 28 sites in Japan
- Volunteers
- 239 people
- Sponsor
- GlaxoSmithKline
Otitis Media
Acute Otitis Media: Adjuvant Therapy to Improve Outcome
Acute otitis media is one of the most common diseases of childhood and is one of the major causes of hearing loss in children. Despite the availability of effective antibiotic therapy for otitis media, treatment failures…
- Trial name
- NCT00000363
- Testing
- Antihistamine, Corticosteroid
- Where
- United States
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Allergic Rhinitis
Fexofenadine HCl 180 mg, Desloratadine 5 mg and Placebo in Suppression of Wheal and Flare Induced by Histamine
To examine the relative potency, onset of action and duration of action of fexofenadine HCl 180 mg (ALLEGRA) and desloratadine 5 mg (CLARINEX) as compared to placebo on skin wheals and flares induced by histamine.
- Trial name
- NCT00637585
- Testing
- Fexofenadine
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Sanofi
Perennial Allergic Rhinitis
A Long-Term Study of TAU-284 in Pediatric Patients With Perennial Allergic Rhinitis
The objective of this study is to evaluate the long-term safety and efficacy of TAU-284 (Bepotastine besilate) in pediatric patients with perennial allergic rhinitis for 12 weeks administration.
- Trial name
- NCT01900054
- Testing
- Bepotastine besilate
- Where
- Japan
- Volunteers
- 58 people
- Sponsor
- Tanabe Pharma Corporation