Clinical trials: Hookworm Infection
Trichuriasis, Strongyloidiasis
Combination Therapies for Trichuris Trichiura Infection in Schoolchildren in Honduras
The goal of this Phase III clinical trial is to evaluate the efficacy, safety, and acceptability of different treatment regimens for Trichuris trichiura infection in schoolchildren aged 6 to 15 years living in La Moskitia…
- Conditions
- Trichuriasis, Strongyloidiasis, Ascariasis, Hookworm Infection
- Trial name
- AIM-T (NCT07661316)
- Testing
- Albendazole 400 mg, Albendazole Plus Ivermectin, Fixed-Dose Combination Albendazole/Ivermectin (FDC)
- Where
- Honduras
- Volunteers
- 368 people
- Sponsor
- Mundo Sano Foundation
Hookworm Infections
Efficacy and Safety of a New Chewable Versus the Swallowable Tablet of Mebendazole Against Hookworm
The rational of this study is to provide evidence on the safety and efficacy of a new chewable tablet of mebendazole compared to the standard tablet in preschool- and school-aged children infected with hookworm.
- Trial name
- CHEW_MEB_PEMBA (NCT03995680)
- Testing
- Mebendazole
- Where
- Tanzania
- Volunteers
- 397 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Helminthes; Infestation, Intestinal
Evaluation of Effectiveness of ALBENDAZOLIVERMECTIN Coformulation vs ALBENDAZOLE for Treatment of Intestinal Worms
The purpose of this clinical trial is to evaluate a fixed-dose co-formulation (FDC) of ivermectin and albendazole for the treatment of all Soil Transmitted helminths (STH).
- Trial name
- ALIVE (NCT05124691)
- Testing
- Albendazole and Ivermectin fixed dose coformulation, Albendazole
- Where
- 3 sites in Ethiopia, Kenya and 1 more
- Volunteers
- 1,001 people
- Sponsor
- Barcelona Institute for Global Health
Trichuriasis, Ascariasis
Efficacy and Safety of Moxidectin-Albendazole Co-administration in SAC
This study is a double-blind randomized controlled superiority trial aiming at providing evidence on the efficacy and safety of co-administered moxidectin and albendazole compared to albendazole monotherapy in school-aged…
- Conditions
- Trichuriasis, Ascariasis, Hookworm Infections
- Trial name
- Moxiped (NCT06188715)
- Testing
- Moxidectin 2 mg Oral Tablet, Albendazole 400 mg Oral Tablet
- Where
- Tanzania
- Volunteers
- 224 people
- Sponsor
- Jennifer Keiser
Trichuriasis, Hookworm Infections
Albendazole Dose Finding and Pharmacokinetics in Children and Adults
This study is a single-blind randomized clinical trial conducted in rural Côte d'Ivoire. This study aims at providing evidence on the dose-response of increasing oral albendazole dosages against whipworm (T.
- Trial name
- NCT03527745
- Testing
- Albendazole
- Where
- Côte d’Ivoire
- Volunteers
- 700 people
- Sponsor
- Jennifer Keiser
Hookworm
Study to Test Whether Shoes Protect Children Against Hookworm Infection on Pemba Island, Zanzibar
Small association studies have hypothesised that shoes protect against hookworm infection. The purpose of this pragmatic study was determine, under field conditions, whether school-age children on Pemba Island, Zanzibar, would…
- Trial name
- SKIP (NCT01869127)
- Testing
- Shoes
- Where
- Tanzania
- Volunteers
- 1,056 people, healthy volunteers welcome
- Sponsor
- Bird, Christopher
Testing, Performance
Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections.
Malaria, schistosomiasis and ancylostomiasis are three parasitic diseases which affect hundreds of millions of people and are an important cause of global mortality and morbidity.
- Conditions
- Testing, Performance, Specificity, Sensitivity
- Trial name
- INSPiRED-WP3 (NCT04505046)
- Where
- Gabon
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche Médicale de Lambaréné
Ascariasis, Trichuriasis
Effectiveness of Combined Albendazole and Ivermectin Treatment for Intestinal Worm Infections
The aim of this study is to compare the efficacy and impact on growth of two drug treatments against intestinal worms in schoolchildren from a rural area of Guatemala.
- Conditions
- Ascariasis, Trichuriasis, Hookworm Infection, Strongyloidiasis
- Trial name
- NCT00207753
- Testing
- albendazole vs. combined albendazole/ivermectin treatment
- Where
- Guatemala
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Helminthiasis
Study of the Efficacy of Oxfendazole Compared to Albendazole in the Treatment of Trichuris Trichiura Infection in Adults
The aim of this study is to provide data on the efficacy of oxfendazole against Trichuris trichiura at different doses in comparison to the standard single 400 mg dose of albendazole.
- Trial name
- NCT02636803
- Testing
- oxfendazole, albendazole
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diarrhoeal Disease, Hookworm Infection
Evaluating Impact of Improved Floors on Health
The goal of this intervention study is to learn about the impact of household flooring on health in rural Kenya, and test whether providing an improved (cement stabilised, washable) floor improves the health of children and their…
- Conditions
- Diarrhoeal Disease, Hookworm Infection, Ascaris Lumbricoides Infection, Trichuris Infection
- Trial name
- SABABU (NCT05914363)
- Testing
- Sealed washable floor plus behaviour change, Behaviour change intervention, Routine deworming
- Where
- Kenya
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Soil-transmitted Helminth Infections
Community Health Education and Hygiene Promotion Added to Deworming Among Ethnic Khmer Children in Vietnam
This study evaluated whether adding community health education and household hygiene promotion to supervised deworming could improve soil-transmitted helminth (STH) outcomes and related caregiver and household factors among…
- Trial name
- NCT07855978
- Testing
- Albendazole 400 mg, Community Health Education and Hygiene Promotion
- Where
- 4 sites in Vietnam
- Volunteers
- 704 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Trichuris Trichiura; Infection, Hookworm Infection
Efficacy and Safety of Emodepside in Participants With Soil-transmitted Helminth Infections
This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.
- Conditions
- Trichuris Trichiura; Infection, Hookworm Infection, Ascaris Lumbricoides Infection
- Trial name
- TREMO-Siargao (NCT06800248)
- Testing
- emodepside (BAY 44-4400), Mebendazole 100 MG
- Where
- Philippines
- Volunteers
- 315 people
- Sponsor
- Swiss Tropical & Public Health Institute
Hookworm Infection
Triple Combinations Against Hookworm Infections in Lao
More than one billion people are infected with soil-transmitted helminths (STH, A. lumbricoides, hookworm or Trichuris trichiura). Preventive chemotherapy - i.e.
- Trial name
- Tricombi (NCT03278431)
- Testing
- Albendazole, Pyrantel Pamoate, Oxantel Pamoate
- Where
- Laos
- Volunteers
- 420 people
- Sponsor
- Swiss Tropical & Public Health Institute
Malaria,Falciparum, Neglected Tropical Diseases
Adjunctive Ivermectin Mass Drug Administration for Malaria Control
This is a cluster-randomized placebo-controlled clinical trial to evaluate the additive benefit of Ivermectin (IVM) (or Placebo) mass drug administration (MDA) to dihydroartemisinin-piperaquine (DP) MDA for malaria control in a…
- Conditions
- Malaria,Falciparum, Neglected Tropical Diseases, Strongyloidiasis, Lymphatic Filariasis
- Trial name
- MATAMAL (NCT04844905)
- Testing
- Ivermectin, Dihydroartemisinin-piperaquine
- Where
- Guinea-Bissau
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Hookworm Infections
Efficacy and Safety of Emodepside in Adolescents and Adults Infected With Hookworm
To compare the efficacy and safety of emodepside to that of albendazole (Zentel®) in participants aged 12-60, inclusive, infected with hookworm.
- Trial name
- NCT05538767
- Testing
- Emodepside, Albendazole 400mg
- Where
- Tanzania
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jennifer Keiser
Onchocerciasis, Ascaris Lumbricoides Infection
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass drug administration (MDA) in…
- Conditions
- Onchocerciasis, Ascaris Lumbricoides Infection, Trichuris Trichiura; Infection, Hookworm Infections
- Trial name
- EKAIO (NCT07145736)
- Testing
- Moxidectin, Ivermectin
- Where
- Angola
- Volunteers
- 52,000 people, healthy volunteers welcome
- Sponsor
- Kirby Institute
Soil-Transmitted Helminthiasis (STH)
Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Soil Transmitted Helminthiasis (STH)
This is a Phase 3, multi-center, prospective, randomized, double-blind, placebo-controlled study to evaluate the effectiveness, safety, and tolerability of ZP5-9676 compared to placebo for the treatment of STH infections.
- Trial name
- NCT06128447
- Testing
- ZP5-9676 600 mg dose
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- Zero Point Five Therapeutics
Hookworm Stool Burden, Anemia
Does Treating Hookworm Improve Productivity of Small Subsistence Farmers
Treatment of hookworm infected groups with albendazole has been shown to result in an increase in hemoglobin levels and a related decrease in the prevalence of anemia.
- Conditions
- Hookworm Stool Burden, Anemia, Exercise Tolerance
- Trial name
- NCT02102321
- Testing
- albendazole
- Where
- Republic of the Congo
- Volunteers
- 300 people
- Sponsor
- Salmon, Margaret, M.D.
Necator Americanus Infection
Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
Mebendazole tablets which are produced by most pharmaceutical manufacturers, including the State Pharmaceutical Manufacturing Corporation (SPMC) of Sri Lanka, contain a mixture of polymorphs A and C.
- Trial name
- NCT01350271
- Testing
- Mebendazole polymorph A and C 500 mg, Mebendazole polymorph C
- Where
- 2 sites in Sri Lanka
- Volunteers
- 214 people
- Sponsor
- University of Kelaniya