Clinical trials: Hope
Hope, Nursing
The Effect of the Solution-Focused Approach on Social Participation Skills and Hope in Children Living in Residential Care Objective: This Study Aimed to Evaluate the Effect of a Solution-focused Approach Program on the Hope Levels and Social Participation Skills of Children Living in Institutional
his study examined whether a solution-focused approach program could improve hope and social participation skills in children living in institutional care.
- Conditions
- Hope, Nursing, Social Acceptance
- Trial name
- NCT07135908
- Testing
- solution-oriented approach
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Muş Alparslan University
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Cirrhosis, Liver, AKI
Dextran, a Plasma Expander, Offers New Hope for Patients With Decompensated Liver Cirrhosis and Acute Kidney Injury
A pilot study of Dextran-40 infusion in patients with decompensated cirrhosis presenting with AKI
- Trial name
- NCT03070353
- Testing
- Dextran 40
- Volunteers
- 10 people
- Sponsor
- Ramathibodi Hospital
Psychological Well-being, Gratitude
Effects of School-Based Ignatian Examen Meditation on Well-Being, Gratitude, Hope, and Spirituality in Hong Kong Catholic Primary School Students
This study aims to investigate the effects of Ignatian Examen Meditation on students' psychological well-being, gratitude, hope, and spirituality.
- Conditions
- Psychological Well-being, Gratitude, Hope, Spirituality
- Trial name
- NCT07857980
- Testing
- Examen Meditation
- Where
- Hong Kong
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Hand-washing Behavior, Diarrhea
The Hope Soap Study: a Hand-washing Intervention Among Children in South Africa
The Hope Soap Study is a randomised-control pilot study of a hand-washing intervention in which children in treatment households received a bi-monthly delivery of HOPE SOAP©, a colourful, translucent bar of soap with a toy…
- Trial name
- NCT03280771
- Testing
- Hope Soap, Control group soap
- Volunteers
- 288 people
- Sponsor
- University of Cape Town
Heart Transplant Failure and Rejection, Coronary Artery Disease
Percutaneous Coronary Intervention in Patients witH OrthotoPic hEart Transplantation: the PCI-HOPE a Multicenter Study.
This is a retrospective, multicenter, study including patients undergone to one or more percutaneous revascularization after OHT.
- Trial name
- PCI-HOPE (NCT03538509)
- Testing
- PCI and implantation drug eluting stent or bare metal stent
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fabrizio D'Ascenzo
Alzheimer Disease, Early Onset
Adapted Home-based Exercise Program "T&E" (Test-and-Exercise) in Persons With Alzheimer's Disease (HOPE Trial)
The aim of this exploratory pilot study is to assess the feasibility and effectiveness of the adapted T\&E home-based exercise program on the basic functional mobility and executive functions in persons with mild or probable…
- Trial name
- HOPE (NCT04916964)
- Testing
- Test and exercise home-based program
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- HES-SO Valais-Wallis
Youth Mental Health
WeRISE: Youth-led Mental Health Transformation Through Cultivating Gratitude, Kindness, and Hope
The weRISE study's primary aim is to develop and test the effects of an arts-based train-the-trainer intervention developed to cultivate gratitude, kindness, and hope among youth in schools and informal settlements in both India…
- Trial name
- NCT05944263
- Testing
- weRISE; The gratitude, kindness and hope (GKH) program, The [adapted] Stan Kutcher Teen Mental Health (TMH) program
- Where
- 2 sites in India, Kenya
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- citiesRISE
Duchenne Muscular Dystrophy
Halt cardiomyOPathy progrEssion in Duchenne (HOPE-OLE)
This Phase 2, multi-center, open-label extension trial will provide CAP-1002 to participants who were randomized to the Usual Care treatment group of the HOPE-Duchenne study (NCT02485938) and completed 12 months of follow-up.
- Trial name
- HOPE-OLE (NCT06304064)
- Testing
- Allogeneic Cardiosphere-Derived Cells (CAP-1002)
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Capricor Inc.
Child With Cancer, Muscular Atrophy, Spinal
A BHI to Increase Hope Level and Stress Level of Parents With a CMC
Being a parent of a child with medical complexity (CMC) poses an enormous stress because these CMC have a multisystem disease, a severe neurologic condition or cancer which may result in premature death.
- Conditions
- Child With Cancer, Muscular Atrophy, Spinal, Child With Cerebral Palsy, Endocrine System Diseases
- Trial name
- NCT05269693
- Testing
- Brief Hope Intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Giant Axonal Neuropathy (GAN)
Intraneural Administration of scAAV9/JeT-GAN Into the Vagus Nerve for Patients With Giant Axonal Neuropathy (GAN)
Giant axonal neuropathy (GAN) is a rare pediatric disorder caused by autosomal recessive mutations in the GAN gene. GAN is a multisystem, neurodegenerative disorder affecting the peripheral nervous system (PNS), central nervous…
- Trial name
- NCT07543991
- Testing
- scAAV9/JeT-GAN
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Texas Southwestern Medical Center
Pediatric
Posıtıve Psychology-Based Art Therapy In Hospıtalızed Chıldren
Pediatric hospitalization is known to be associated with negative developmental and psychosocial outcomes for child patients. Art therapy is a way to directly address the emotional world of hospitalized children.
- Trial name
- PP-ArtChild (NCT07735364)
- Testing
- Posıtıve Psychology-Based Art Therapy In Hospıtalızed Chıldren (PP-ArtChild)+Routine Pediatric Nursing Care, Routine Pediatric Nursing Care
- Volunteers
- 80 people
- Sponsor
- Suleyman Demirel University
Gestational Weight Gain, Diet, Healthy
Delivering HOPE (Helping Women Optimize Prenatal Equity)
The overarching research question is: "Does the provision of healthy food (Delivering HOPE) during pregnancy reduce the proportion of women who experience excessive gestational weight gain compared with enhanced standard of care…
- Conditions
- Gestational Weight Gain, Diet, Healthy, Gestational Hypertension, Gestational Diabetes
- Trial name
- NCT06814509
- Testing
- Enhanced Standard of Care (ESoC), Delivering HOPE
- Where
- 8 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Oral Feeding Outcomes, Neurodevelopment Outcome
Impact of Hospital to Home: Optimizing Preterm Infant Environment for Surgical Neonates and Their Parents (H-HOPE)
Infants born with congenital defects may require major surgery in the neonatal period. These infants are at risk for neurodevelopmental impairments.
- Trial name
- H-HOPE (NCT07372898)
- Testing
- H-HOPE
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Posttraumatic Stress Disorder
Couple HOPES (Helping Overcome PTSD and Enhance Satisfaction)
Posttraumatic stress disorder (PTSD) is a common and disabling condition associated with intimate relationship problems and mental health problems in partners of those with PTSD.
- Trial name
- HOPES (NCT04231578)
- Testing
- Couple HOPES Guided, Internet-Delivered, Self-Help Intervention
- Where
- Canada
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Sickle Cell Disease
Study to Evaluate the Effect of GBT440 on TCD in Pediatrics With Sickle Cell Disease
This study is a Phase 3, randomized, double-blind, placebo-controlled study of voxelotor in pediatric participants, aged ≥ 2 to < 15 years old, with Sickle Cell Disease.
- Trial name
- HOPE Kids 2 (NCT04218084)
- Testing
- Voxelotor
- Where
- 35 sites in United States, Egypt and 7 more
- Volunteers
- 236 people
- Sponsor
- Pfizer
Suicide
Preventing Suicide in African American Adolescents
The overarching aim of the Success Over Stress Prevention Project is to reduce African American youth suicide. This study examines the impact of a 15-session, group-delivered, culturally-grounded, cognitive-behavioral…
- Trial name
- NCT04253002
- Testing
- Robinson's Culturally Adapted Coping with Stress Course (A-CWS), Standard Care Control Condition
- Where
- 6 sites in United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- DePaul University
Craniofacial Differences
Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences
This study will describe the use of an intervention, developed by an organization called Positive Exposure, to improve self-perceptions among adolescents and young adults who may encounter the stigma, or negative effect, of…
- Trial name
- NCT00340964
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Human Genome Research Institute (NHGRI)