Clinical trials: Hyaluronic Acid
Medication Related Osteonecrosis of the Jaw
MRONJ and Polynucleotides-Hyaluronic Acid Hydrogel (Regenfast®)
Several circumstances or conditions, such as wound extension or disease, can affect the hard and soft tissue healing after surgical treatment of MRONJ. Supportive therapies are therefore needed to help tissues wound healing.
- Trial name
- REG-MRONJ-1 (NCT06984107)
- Testing
- MRONJ resection plus PN+HA
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Bilateral Cataract, Unilateral Cataract
Comparison of the Safety and Efficacy of Ophtesis Bio 3% With a Similar 3% Sodium Hyaluronate OVD
Prospective, randomized, subject/evaluator-masked post market clinical study at up to 2 sites at Gemini eye clinic in Czech Republic. Randomization will be done by the eye surgeon.
- Trial name
- NCT05832749
- Testing
- Ophtesis Bio 3% ophthalmic viscosurgical device, Healon Endocoat 3% ophthalmic viscosurgical device
- Where
- 3 sites in Czechia
- Volunteers
- 296 people
- Sponsor
- Gemini Eye Clinic
Steroid Induced Glaucoma
Trabeculectomy With Ologen Collagen Implant vs Trabeculectomy With Provisc in Steroid Induced Glaucoma
The purpose of this prospective randomized study is to assess and compare the clinical efficacy and safety of primary trabeculectomy with Ologen® collagen implant and cohesive viscoelastic (Provisc®) - augmented trabeculectomy in…
- Trial name
- NCT01912638
- Testing
- Ologen Collagen Matrix, Provisc
- Where
- Azerbaijan
- Volunteers
- 17 people
- Sponsor
- National Centre of Ophthalmology named after academician Zarifa Aliyeva
Hyaluronic Acid, Fat Graft
Clinical Evaluation of Interdental Papilla Reconstruction Using Injectable Autogenous Fat Versus Hyaluronic Acid Filler.
The goal of this randomized controlled trial is to evaluate the amount of interdental papilla fill following the injection of the fat graft compared to hyaluronic acid filler in patients with interdental papilla deficiency.
- Trial name
- NCT05579522
- Testing
- Fat graft injection, Hyaluronic acid injection
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Epistaxis
Outcome of Hyaluronic Acid Gel Versus Petroleum Jelly in Treatment of Epistaxis
The aim of this study is to compare the efficacy of Hyaluronic Acid Gel with Petroleum Jelly in treatment of epistaxis.
- Trial name
- NCT07531472
- Testing
- Hyaluronic Acid Gel, Petroleum jelly
- Volunteers
- 50 people
- Sponsor
- Assiut University
Vesico-Ureteral Reflux
A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children
Vesicoureteral reflux (VUR) is the most common urologic diagnosis in neonates estimated at 1% of newborns, and 30-45% of the children who present with urinary tract infection (1).
- Trial name
- NCT02271035
- Testing
- Deflux, Vantris
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Dehydration
Study of Subcutaneous Rehydration With Recombinant Human Hyaluronidase for Infants and Children
The aim of the study is to evaluate the safety, effectiveness and ease of use of subcutaneous (SC) rehydration using HYLENEX-augmented SC infusion of fluids and electrolytes for the rehydration of pediatric patients with mild to…
- Trial name
- INFUSE-PR (NCT00477152)
- Testing
- hyaluronidase (human recombinant)/rehydration fluid
- Volunteers
- 52 people
- Sponsor
- Baxter Healthcare Corporation
Chronic Periodontitis
Hyaluronic Acid With Scaling & Root Planing In Chronic Periodontitis Patients With Diabetes Mellitus Type 2
The present study aimed to assess the adjunctive use of Hyaluronic acid with scaling \& root planing (SRP) in patients with chronic periodontitis \& diabetes mellitus type 2.
- Trial name
- NCT03807596
- Testing
- Periodontal treatment with Hyaluronic acid associated with SRP, Scaling & root planning alone
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Brain and Central Nervous System Tumors, Chordoma
Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer
RATIONALE: Polyvinylpyrrolidone-sodium hyaluronate gel may lessen the pain of oral mucositis, or mouth sores, in patients undergoing treatment for cancer.
- Conditions
- Brain and Central Nervous System Tumors, Chordoma, Kidney Cancer, Leukemia
- Trial name
- NCT00349024
- Testing
- polyvinylpyrrolidone-sodium hyaluronate gel
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Periodontitis, Gingival Recession, Localized
Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in Supraosseous Periodontal Defects Treated with the Single Flap Approach
Treatment of supraosseous defects (SD) may be challenging due to their limited regenerative potential. When located in aesthetic areas, treatment may result in a gingival recession increase with consequent patients' concerns in…
- Conditions
- Periodontitis, Gingival Recession, Localized, Aesthetic Perception, Aesthetic Outcomes
- Trial name
- SFA-SD (NCT06897085)
- Testing
- viscoelastic gel containing polynucleotides and hyaluronic acid, No intervention
- Volunteers
- 70 people
- Sponsor
- Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy
Frenulectomy
Effects of Epithelialization-enhancing Agents Following Diode Laser-assisted Frenectomy: A Randomized Clinical Trial
The purpose of this randomized clinical trial is to evaluate and compare the effects of two topical epithelialization-enhancing agents-a hyaluronic acid-based gel (Gengigel®) and a bioactive micronutrient-based gel…
- Trial name
- NCT07773701
- Testing
- Hyaluronic Acid Gel (Gengigel®), Bioactive Micronutrient Gel (Miradont®-Gel)
- Where
- Croatia
- Volunteers
- 45 people
- Sponsor
- University of Zagreb
Oral Mucositis
Is Hyaluronic Acid Gel Effective on Oral Mucositis in Children Who Receiving Chemotherapy
Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT.
- Trial name
- NCT05818007
- Testing
- Hyaluronic acid, Sodium bicarbonate
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Yuzuncu Yil University
Pulpotomies Primary Teeth, Pulp Disease, Dental
Clinical and Radiographic Evaluation of Hyaluronic Acid (Gengigel Teething) Versus Mineral Trioxide Aggregate( Angelus) as Pulpotomy Agent in Vital Primary Molars
The goal of this clinical trial is to Clinical and Radiographic Evaluation of Hyaluronic Acid (Gengigel Teething) Versus Mineral Trioxide Aggregate( Angelus) as Pulpotomy Agent in Vital Primary Molars.
- Trial name
- HA - MTA (NCT06611631)
- Testing
- Hyaluronic acid pulpotomy, mineral trioxide aggregate pulpotomy
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Cairo University
Acne Vulgaris
Efficacy and Safety of Adapalene Gel and Hyaluronic Acid Versus Adapalene Gel Alone in Mild to Moderate Acne Vulgaris
Acne vulgaris affects around 85% of adolescents and young adults. Adapalene, a topical retinoid, is a common treatment but often causes irritation, leading to poor adherence.
- Trial name
- NCT07102186
- Testing
- use of adapalene gel 0.1% and hyaluronic acid at bedtime, use of adapalene gel 0.1% once daily at bedtime
- Where
- Egypt
- Volunteers
- 93 people
- Sponsor
- Badr University
Gingivitis
Hyaluronic Acid and Gingivitis in Pediatrics
The purpose of this observational, non-controlled, single site trial with a retrospective design is to verify, in a large paediatric population affected by gingivitis, the tolerability and safety of 0.1% HA-based film-forming…
- Trial name
- NCT03003858
- Testing
- 0.1% HA-based film-forming device (Gengigel Prof® Fluid)
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Dehydration
Efficacy and Time and Resources for Hylenex-facilitated SC Rehydration Versus ORT for Dehydrated Children in the Emergency Department (ED)
The purpose is to evaluate the safety and efficacy as well as the time and resources needed in the ED setting to achieve rehydration in young pediatric subjects with mild to moderate dehydration using hylenex-facilitated SC…
- Trial name
- INFUSE-TM (NCT01120431)
- Testing
- Oral rehydration fluid, Isotonic hydration fluid and recombinant human hyaluronidase
- Sponsor
- Baxter Healthcare Corporation
Pulpotomies Primary Teeth, Pulp Disease, Dental
Comparison of Hyaluronic Acid, TheraCal, and Mineral Trioxide Aggregate as Pulpotomy Agents in Primary Molars
This randomized clinical trial aims to evaluation the clinical and radiographic outcomes of hyaluronic acid, TheraCal, and Mineral Trioxide Aggregate (MTA) when used as pulpotomy agents in primary molars.
- Trial name
- NCT07168811
- Testing
- Hyaluronic Acid (HA), TheraCal, Mineral Trioxide Aggregate
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Al-Azhar University
Pulpitis
Evaluation of Hyaluronic Acid Pulpotomies in Primary Molars
In this study, 120 primary molar teeth from healthy children aged between 5 and 9 and who apply to Marmara University Faculty of Dentistry, Department of Pediatric Dentistry will be subjected to pulpotomy treatments.
- Trial name
- NCT04115358
- Testing
- Hyaluronic acid: Gengigel teething, Formocresol Buckley formula: Formacresol, Ferric sulfate: ViscoStat
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Marmara University
Gingivitis, Bleeding Gum
Efficacy of Hyaluronic-acid and Hydrogen-Peroxide Mouthwash in Gingivitis Treatment
A clinical study to evaluate the efficacy and safety of a mouthwash containing Hydrogen Peroxide, Sodium Hyaluronate and Glycine in the prevention and management of complications associated gingivitis by film forming action.
- Trial name
- NCT04438421
- Testing
- Filming mouthwash formulation, enriched with Hydrogen Peroxide and Hyaluronic Acid, Chlorhexidine mouthwash
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Milan
RT II Gingival Recession
Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession
This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession.
- Trial name
- NCT07771244
- Testing
- Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University