Clinical trials: Hypercapnic Respiratory Failure
High-Flow Nasal Cannula, COPD
Effect of Postextubation High-Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypercapnic COPD
To test if high-flow conditioned oxygen therapy is noninferior to NIV for preventing postextubation respiratory failure and reintubation in patients with hypercapnic COPD, investigators plan to conduct the participants level, 1:1…
- Trial name
- COPD (NCT03928535)
- Testing
- High-FlowNasal Cannula, Noninvasive Ventilation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Hypercapnic Respiratory Failure
Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure
The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.
- Trial name
- NCT00775710
- Testing
- Nocturnal non-invasive ventilation
- Where
- 3 sites in Spain
- Volunteers
- 128 people
- Sponsor
- Hospital Clinic of Barcelona
Acute Mechanical Ventilatory Failure
Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation
Although High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its…
- Trial name
- RescueHFO (NCT02752438)
- Testing
- HFOV
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Ankara University
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease
Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation
Background: In chronic obstructive pulmonary disease, the prognosis for patients who have survived an episode of acute hypercapnic respiratory failure due to an exacerbation is poor.
- Conditions
- Chronic Obstructive Pulmonary Disease, Acute Exacerbation of Chronic Obstructive Airways Disease, Chronic Hypercapnic Respiratory Failure
- Trial name
- NCT01513655
- Testing
- LTNIV
- Where
- 4 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Respiratory Insufficiency
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation
Procedural sedation is an established and safe intervention and is widely used in diagnostic and therapeutic procedures for pediatric patients.
- Trial name
- HiFiPPS (NCT02930525)
- Testing
- High Flow nasal cannula, Standard respiratory care
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Freiburg
Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure
Comparing Closed-loop FiO2 Controller With Conventional Control of FiO2
During mechanical ventilation (MV) hypoxemic or hyperoxemic events should be carefully monitored and a quick response should be provided by the caregiver at the bedside.
- Conditions
- Acute Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxemic and Hypercapnic Respiratory Failure
- Trial name
- NCT04568642
- Testing
- Activate FiO2 controller, Deactivate FiO2 controller
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Dr. Behcet Uz Children's Hospital
Neuromuscular Diseases, Central Hypoventilation
'Fitness To Fly' Tests In Children With Type II Respiratory Failure
The conventional hypoxic challenge test might not predict 'fitness-to-fly' equally well in all patients. Patients at risk of hypercapnia with supplemental oxygen are not well studied.
- Trial name
- NCT03824223
- Testing
- Hypoxic challenge test
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Anesthesia, Cardiac Disease
High Flow Nasal Oxygen During Sedation
The primary objective of this study is to test the hypothesis that using high flow nasal oxygen improves ventilation during cardiac implantable electronic device procedures performed with conscious sedation.
- Trial name
- NCT03858257
- Testing
- High flow nasal oxygen, Standard oxygenation
- Where
- Canada
- Volunteers
- 129 people
- Sponsor
- University Health Network, Toronto
Ventilatory Failure
Neo RQI: The Effect of Neonatal Resuscitation Quality Improvement Cart Booster Training Skills Retention
This is a prospective multicenter randomized control trial to assess percentage mask leak six months post instructor led positive pressure ventilation skills training in providers who undergo booster training compared to those…
- Trial name
- NCT05147922
- Testing
- Booster Training with the Neonatal Resuscitation Quality Improvement Cart
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Respiratory Insufficiency
High Flow Nasal Oxygen Therapy in Pediatric Hypercapnic Respiratory Failure During Perioperative Stage
Humidified high flow nasal oxygen therapy decreases dilution of the inhaled oxygen and, by matching patient's peak flow, allows accurate delivery of the set FiO2 throughout the whole inspiratory phase.The purpose of this study is…
- Trial name
- NCT03534960
- Testing
- High Flow Nasal Oxygen Therapy, Nasal CPAP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Ventilatory Failure
Comparison of Two Different NCPAP Methods in Preterm Infants With Respiratory Distress Syndrome
is to compare introduction of two different NCPAP methods in terms of mechanical ventilation (MV) need (non-invasive respiratory support failure) and surfactant need within the first 72 hours of life in preterm infants with…
- Trial name
- (NCPAP) (NCT03400670)
- Testing
- ventilator NCPAP
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Pulmonary Disease, Chronic Respiratory Failure
Home Mechanical Ventilation Effectiveness and Air Leaks
Non invasive ventilation (NIV) usually presents air leaks that may determine the result of this treatment. The clinical usefulness of analyzing (and quantifying) these leaks during the adaptation period to NIV has not been…
- Conditions
- Pulmonary Disease, Chronic Respiratory Failure, COPD
- Trial name
- NCT01090986
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome
Patient -Ventilator Interaction in Chronic Respiratory Failure
To evaluate a novel advanced physiological monitoring system to improve nocturnal non-invasive ventilation (NIV) in Neuromuscular disease (NMD), Chest wall disease (CWD), Chronic Obstructive Pulmonary Disease (COPD) and Obesity…
- Conditions
- Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome, Neuromuscular Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT01371149
- Testing
- Surface parasternal electromyography (EMG) set up
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- Michelle Ramsay