Clinical trials: Hypertension, Pregnancy-Induced
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Hypertension, Hypertension, Pregnancy-Induced
The Relaxation and Blood Pressure in Pregnancy (REBIP) Study
Over 10% of women have high blood pressure during their pregnancy which may affect their health or that of their baby. There are currently no methods to prevent most high blood pressure in pregnancy and some treatments are not…
- Conditions
- Hypertension, Hypertension, Pregnancy-Induced, Pre-Eclampsia
- Trial name
- NCT00303173
- Testing
- Guided Imagery
- Where
- 2 sites in Canada
- Volunteers
- 69 people
- Sponsor
- University of Toronto
Pre-Eclampsia
Indonesia Pravastatin to Prevent Preeclampsia Study
BACKGROUND Preeclampsia is a major cause of maternal and neonatal morbidity worldwide. There is currently no cure for preeclampsia, the only definitive treatment is termination of pregnancy by induction of labour or caesarean…
- Trial name
- INOVASIA (NCT03648970)
- Testing
- Pravastatin
- Where
- 7 sites in Indonesia
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universitas Airlangga
Pre-Eclampsia; Complicating Pregnancy, Pre-eclampsia Aggravated
Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU
Severe pre-eclamptic toxemia has a high incidence of renal complications. Rapid diagnosis and termination of pregnancy are still the gold standard main treatment for pre-eclampsia.
- Trial name
- NCT05687669
- Testing
- Glyceryl trinitrate vs phentolamine for prophylaxis against renal impairment
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Assiut University
Preeclampsia and Eclampsia
Springfusor for Administration of Magnesium Sulphate in Preeclampsia and Eclampsia
Magnesium Sulphate is the drug of choice for prevention and treatment of seizures in preeclampsia and eclampsia. It is administered parenterally by intravenous (IV) and or intramuscular (IM) routes.
- Trial name
- NCT03549767
- Testing
- Springfusor, Standard of care
- Where
- Uganda
- Volunteers
- 241 people
- Sponsor
- Makerere University
Postpartum CVD Risk in Women With Previous Preeclampsia.
Preeclampsia and Circulating Biomarkers
In order to assess circulating biomarkers of cardiovascular risk, we will conduct a 10-year follow-up study comparing 32 exposed (women with a history of pregnancy complicated by preeclampsia) and 32 unexposed (women with a…
- Trial name
- NCT02136667
- Where
- Denmark
- Volunteers
- 64 people
- Sponsor
- University of Aarhus
Pre-Eclampsia
Neurobehavioural Outcomes in Late Preterm Neonates
Hypertensive disorders are the most common medical complications in pregnancy and major causes of maternal, fetal, and neonatal morbidity and mortality.
- Trial name
- PRENB (NCT02443259)
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Lady Hardinge Medical College
Sepsis, Pneumonia
Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project
The purpose of this study is to determine whether an integrated EmONC package (community mobilization, training of community-based health care providers and a maternal and neonatal health pack) reduce perinatal and neonatal…
- Conditions
- Sepsis, Pneumonia, Omphalitis, Birth Asphyxia
- Trial name
- EmONC (NCT01751945)
- Testing
- EmONC package
- Where
- Pakistan
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Preeclampsia
Hypertensive Disorders of Pregnancy in Adolescence and Primipaternity
Hypertensive disorders of pregnancy are one of the most frequent complications of pregnancy, being a serious health problem around the world.
- Trial name
- NCT01374477
- Where
- Panama
- Volunteers
- 110 people
- Sponsor
- Saint Thomas Hospital, Panama
Cardiovascular Diseases, Heart Diseases
Regulation of Placental Vascular Reactivity in Pregnancy-induced Hypertension
To elucidate the role of an imbalance in vasodilator prostacyclin (PGI2) and vasoconstrictor thromboxane (TxA2) in pregnancy-induced hypertension
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005208
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Preeclampsia
Assessing the Usability and Clinical Utility of the Congo Red Dot Test: A Survey
To determine if women can understand the instructions, carry out the test, and interpret the test results. Women will be recruited to complete a test instruction and comprehension assessment and a usability assessment.
- Trial name
- NCT02611011
- Testing
- Congo Red Test (GV-005)
- Where
- Mexico
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Preeclampsia
Physical Therapy in Pregnant Women With Preeclampsia
The aim of this study is to evaluate the influence that has a physical therapy protocol in maternal and fetal hemodynamics in relation to blood pressure, maternal and fetal responses and perinatal outcomes.
- Trial name
- FPE (NCT01630772)
- Testing
- Physical therapy, No physical therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Premature Birth, Pre-Eclampsia
Select Nutrient and Gene Variant Analysis in a Targeted Diet and Lifestyle Intervention Reduces Preterm Birth
Preterm birth (PTB) rates in the US are among the highest in wealthy nations across the globe, and they are particularly high in our most socio-economically disadvantaged populations.
- Conditions
- Premature Birth, Pre-Eclampsia, Small for Gestational Age Infant
- Trial name
- SNGLI-PTB (NCT05436119)
- Testing
- GrowBaby
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- GrowBaby Life Project
Hypertensive Disorder of Pregnancy
Improving Maternal Cardiovascular Outcomes Through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria
The goal of this interventional study is to learn from patients and healthcare providers at 4 health institutions (study sites) in Abuja and Kano in Nigeria what ways to best develop the content of a Hypertensive Disorders of…
- Trial name
- IMPACT-HDP (NCT06859359)
- Testing
- Hypertension Disorders of Pregnancy (HDP) Implementation Bundle
- Where
- 4 sites in Nigeria
- Volunteers
- 1,200 people
- Sponsor
- Washington University School of Medicine
Preeclampsia
162 mg of Aspirin for Prevention of Preeclampsia
This is a study to assess if 162 mg of aspirin will decrease rates of preeclampsia in pregnant patients compared to 81 mg of aspirin.
- Trial name
- NCT05221164
- Testing
- Aspirin 162 mg
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Methodist Medical Center of Illinois
Gestational Hypertension, Prematurity
Effects of Exercise During Pregnancy on Maternal and Child Health: a Randomized Clinical Trial
The Pamela Study is a clinical trial carried out during pregnancy to assess the potential effects of physical activity during pregnancy among previously inactive women.
- Conditions
- Gestational Hypertension, Prematurity, Maternal Post-partum Depression, Maternal Post-partum Weight Retention
- Trial name
- PAMELA (NCT02148965)
- Testing
- Physical Exercise / Physical Activity
- Where
- Brazil
- Volunteers
- 639 people, healthy volunteers welcome
- Sponsor
- Federal University of Pelotas
Preterm Birth, Intrauterine Growth Retardation
Fish Oil Trials in Pregnancy for the Prevention of Pregnancy Complications ('FOTIP')
The initial trial examined if fish oil supplementation during pregnancy could reduce the risk of pregnancy induced hypertension, intrauterine growth retardation, and preterm birth in pregnancies that were at increased risk of…
- Conditions
- Preterm Birth, Intrauterine Growth Retardation, Pregnancy Induced Hypertension
- Trial name
- FOTIP (NCT02229526)
- Testing
- Low dose fish oil, Low dose olive oil, High dose fish oil
- Volunteers
- 1,619 people
- Sponsor
- Sjurdur Frodi Olsen
Periodontal Diseases, Premature Birth
Prevention of Pre-Term Birth by Treatment of Periodontal Disease
The aim of the study is to investigate, in an Australian population of pregnant women, whether the treatment of periodontal disease during pregnancy prevents pre-term birth and other complications of pregnancy.
- Conditions
- Periodontal Diseases, Premature Birth, Pre-Eclampsia
- Trial name
- NCT00133926
- Testing
- Treatment of periodontal disease
- Where
- Australia
- Volunteers
- 1,094 people
- Sponsor
- King Edward Memorial Hospital
Preeclampsia, Aspirin
Low Dose Aspirin Alerts in High-Risk Pregnancies
The goal of this study is to assess the effect of an electronic health record (EHR) clinical decision support tool, also known as a best practice alert (BPA), on healthcare provider recommendations for low dose aspirin use in a…
- Conditions
- Preeclampsia, Aspirin, Clinical Decision Support Systems, Economics, Behavioral
- Trial name
- NCT05802940
- Testing
- Electronic health record best practice alert
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- Geisinger Clinic
Severe Preeclampsia, Antiphospholipid Syndrome
Antiphospholipid Antibodies and Early Severe Preeclampsia.
The Antiphospholipid Syndrome is an immune disease where the presence of antibodies directed against cell membrane phospholipids (antiphospholipid antibodies) can cause an hypercoagulable state that causes thrombosis and…
- Trial name
- NCT01538121
- Where
- Panama
- Volunteers
- 310 people
- Sponsor
- Saint Thomas Hospital, Panama