Clinical trials: Hypertensive
Hypertension, Insulin Resistance
Treatment of Insulin Resistance in Hypertensive, Obese Adolescents
In this study, we propose using telmisartan, an angiotensin II receptor antagonist with PPAR-gamma modulating activity, for a 12-week period to decrease blood pressure and insulin levels in obese, hypertensive children.
- Conditions
- Hypertension, Insulin Resistance, Dyslipidemia
- Trial name
- NCT00185705
- Testing
- Telmisartan
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Portal Hypertension, Hepatic Encephalopathy
Phase II Study of Lactulose and Circadian Rhythms in Patients With Cirrhosis
OBJECTIVES: I. Assess the effect of lactulose on the circadian rhythm of plasma melatonin in patients with subclinical hepatic encephalopathy. II.
- Conditions
- Portal Hypertension, Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT00004796
- Testing
- lactulose
- Volunteers
- 16 people
- Sponsor
- National Center for Research Resources (NCRR)
Pulmonary Arterial Hypertension
Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a disease where the blood pressure in the pulmonary arteries (PAP) is high. PAH increases the risk of adverse events, including death, during and or after procedures.
- Trial name
- NCT05439460
- Testing
- Phenylephrine, Epinephrine, Arginine Vasopressin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Hypertension
A Study of Azilsartan in Children From 6 to Less Than 16 Years Old With High Blood Pressure
The main aim of this study is to check for side effects from treatment with azilsartan and how well azilsartan controls blood pressure in children from 6 to less than 16 years old with high blood pressure.
- Trial name
- NCT05107960
- Testing
- Azilsartan (TAK-536)
- Where
- Japan
- Volunteers
- 5 people
- Sponsor
- Takeda
Hypertension
An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age
The purpose of this study is to evaluate in a randomized, double-blind fashion, the long-term safety, tolerability and efficacy profile of aliskiren compared to the active comparator enalapril in children, 6 - 17 years old with…
- Trial name
- NCT01151410
- Testing
- Aliskiren, Enalapril
- Where
- 36 sites in United States, Guatemala and 5 more
- Volunteers
- 208 people
- Sponsor
- Novartis Pharmaceuticals
Cardiovascular Diseases, Hypertension
Blood Pressure Control in African Americans
The purpose of this study is to test the effectiveness of a multi-component evidence-based intervention that targets both patients and physicians, in improving BP control rates in patients followed in 30 Community/Migrant Health…
- Trial name
- NCT00233220
- Testing
- Multicomponent, multi-level intervention targeted at physicians and patients, Usual Care
- Where
- United States
- Volunteers
- 1,039 people
- Sponsor
- NYU Langone Health
Glomerulonephritis, IGA, Hypertension
A Prospective Study of the Kidney Protective Effect of Aliskiren in Hypertensive Patients With IgA Nephropathy
The purpose of this study is to evaluate the effect of aliskiren, a novel direct rennin inhibitor, on renal function and progress of renal disease in hypertensive patients with IgA nephropathy.
- Trial name
- NCT01184599
- Testing
- aliskiren
- Where
- 4 sites in Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Kidney Diseases
China Kidney Patient Trials Network
This is a prospective multi-centre, observational cohort study of incident and prevalent patients diagnosed with a kidney disease in China.
- Trial name
- CKPTN (NCT05036850)
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- George (Beijing) Clinical Research Co. Ltd.
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Cardiovascular Diseases, Heart Diseases
Preventing Weight Gain and Controlling Blood Pressure During Smoking Cessation in Hypertensive Smokers
The purpose of this study is to develop effective interventions that assist individuals with high blood pressure to quit smoking and prevent weight gain.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00113074
- Testing
- Nicotine Replacement Therapy, Diet
- Where
- 2 sites in United States
- Volunteers
- 139 people
- Sponsor
- Mark Vander Weg
Hypertension
Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of Age
This double-blind 8 week study will evaluate dose response, efficacy (blood pressure lowering effect) and safety of aliskiren in children 6 - 17 years old with hypertension at low, mid and high weight-based doses.
- Trial name
- NCT01150357
- Testing
- Aliskiren (6.25/12.5/25 mg), Aliskiren (37.5/75/150 mg), Aliskiren (150/300/600 mg)
- Where
- 48 sites in United States, Belgium and 7 more
- Volunteers
- 267 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
Effect of Valsartan Compared to Enalapril on Sitting Systolic Blood Pressure in Children With High Blood Pressure
The purpose of this 12-week active controlled trial is to evaluate the safety and efficacy of valsartan 80/160/320 mg (weight stratified) compared with enalapril 10/20/40 mg (weight stratified) on sitting systolic blood pressure…
- Trial name
- NCT00433836
- Testing
- Valsartan, Enalapril
- Where
- 11 sites in United States, Belgium and 9 more
- Volunteers
- 300 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
307B - Safety, Tolerability and Pharmacokinetics Study of TOPROL-XL® in Hypertensive Pediatric Subjects
This was a 52-week, multicenter, open-label study to determine the safety, tolerability and pharmacokinetics of TOPROL-XL (metoprolol succinate) extended-release tablets (metoprolol CR/XL) in hypertensive pediatric subjects.
- Trial name
- NCT00255502
- Testing
- metoprolol succinate
- Where
- 31 sites in United States, Dominican Republic
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Hypertensive Patients
Pharmacometric Modeling of a Hospital Preparation
Pediatric prescribers are very often faced with a lack of suitable therapies, particularly oral ones. This represents a major public health problem and necessitates adjustments to dosage or pharmaceutical form using medications…
- Trial name
- PEDIATENS (NCT07372560)
- Testing
- Evaluation of the pharmacokinetic parameters of an oral formulation of nicardipine hydrochloride
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Rouen
Hypertension in Pregnancy
Understanding Blood Pressure Changes After Birth
Research Question How does maternal blood pressure respond in the postpartum period for women who had a hypertensive disorder in pregnancy? Aim To evaluate the recovery of maternal blood pressure after a pregnancy affected by new…
- Trial name
- NCT05137808
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- St George's, University of London
Hypertension
Assessment of Anesthetic Efficacy and Hemodynamic Stability of Two LA Drugs for Hypertensive Patients
Pain control in dentistry is an important factor for reducing the fear and anxiety associated with dental procedures. For tooth extraction, it is mandatory to use resources to manage pain and discomfort such as adequate…
- Trial name
- NCT06927726
- Testing
- 4% Articaine HCL With 1:100,000 Epinephrine, 3% plain mepivacaine HCL
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Coronary Artery Spasm, Hypertension
The Prevalence of Coronary Spasm in Hypertensive Patients Treated With Antihypertensive Medication
Autonomic nerve function is involved in both blood pressure (BP) regulation and the pathogenesis of coronary artery spasm(CAS), but few studies have been published about the relationship between CAS and effect of BP lowering…
- Trial name
- NCT01882790
- Where
- 3 sites in South Korea
- Volunteers
- 1,933 people
- Sponsor
- Korea University
Placental Insufficiency Hypertensive Disorders of Pregnancy Diabetes Mellitus in Pregnancy Thrombophilia in Pregnancy Adverse Perinatal Outcomes
Fetus Programming and Long Active Outcomes, Interaction Between Mother, Placenta and Fetus in Perinatal and Methabolic Disbalansces-focusing Diabetic Pregnancies
The placenta is a temporary but essential organ that develops during pregnancy and supports the growth and survival of the fetus.
- Trial name
- NCT07337759
- Testing
- No intervention (observational study)
- Where
- Serbia
- Volunteers
- 440 people
- Sponsor
- University of Belgrade
Hypertension, Pregnancy
Effects of Dietary Nitrate in Hypertensive Pregnant Women
High blood pressure in pregnancy affects around 10% of pregnancies, and is associated with serious adverse outcomes for both mother and baby.
- Trial name
- NCT02520687
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- University of Manchester
Hypertension, Pregnancy Induced
Hydralazine Versus Labetalol for the Management of Hypertensive Disorders of Pregnancy
Hypertensive crisis (defined as a systolic pressure > 160mmHg or a diastolic pressure > 110mmHg) in patients with a hypertensive disorder of pregnancy is a serious complication with severe and even deadly consequences.
- Trial name
- NCT01538875
- Testing
- Hydralazine, Labetalol
- Where
- Panama
- Volunteers
- 261 people
- Sponsor
- Saint Thomas Hospital, Panama