Clinical trials: Hypertriglyceridaemia
Cardiovascular Diseases, Heart Diseases
Re-evaluating Triglycerides in Coronary Heart Disease
To conduct a comprehensive epidemiologic investigation into the relationship between serum triglyceride (TG) levels and coronary heart disease (CHD).
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertriglyceridemia
- Trial name
- NCT00005442
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peritoneal Dialysis, Pioglitazone
Pioglitazone Attenuates Dysmetabolism in Peritoneal Dialysis (PD) Patients
1. Background:Cardiovascular disease (CVD) is the major cause of mortality in peritoneal dialysis (PD) patients, in whom it is partly attributable to a higher prevalence of dysmetabolism.
- Conditions
- Peritoneal Dialysis, Pioglitazone, Hypertriglyceridemia, Insulin Resistance
- Trial name
- NCT01258322
- Testing
- Pioglitazone
- Volunteers
- 70 people
- Sponsor
- Huashan Hospital
Hypertriglyceridemia
Implitapide in Patients With Hypertriglyceridemia (HTG) on Maximal, Concurrent Triglyceride-Lowering Therapy
The purpose of this study is to determine if implitapide is effective in lowering triglyceride (TG) levels in patients with Fredrickson Type I or V hypertriglyceridemia where the maximum tolerable medication and diet were not…
- Trial name
- NCT00080132
- Testing
- implitapide
- Where
- 9 sites in United States, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Medical Research Laboratories International
Hypertriglyceridemia, Pediatric Obesity
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity.
The primary objective was to evaluate the safety and efficacy the 3 grams per day of omega-3 in adolescents with obesity and hypertriglyceridemia ( ≥ 150 mg/dl and ≤ 1000 mg/dl) for 12 weeks, compared with placebo.
- Trial name
- NCT03216057
- Testing
- Omega-3 fatty acid 3 grams per day
- Volunteers
- 168 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Hypertriglyceridemia
Characterization of Fatty Acid Composition of Triglycerides in Patients With Hypertriglyceridemia-induced Acute Pancreatitis
) Finding a unique pattern in the triglyceride composition of patients with hypertriglyceridemia that increases the chances of getting pancreatitis and which can serve as a laboratory predictive tool for patients and define them…
- Trial name
- NCT04097990
- Testing
- blood sample
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Hypertriglyceridemia, Obesity
Setmelanotide in a Single Patient With Partial Lipodystrophy
The objective of this single patient study is to assess the safety and efficacy of setmelanotide as a treatment of severe metabolic abnormalities resulting from LD, especially refractory hypertriglyceridemia leading to recurrent…
- Trial name
- NCT03262610
- Testing
- Setmelanotide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Hypertriglyceridemia
Effect of Omega-3 Fatty Acid Supplementation on Hypertriglyceridemia in HIV-infected Children
The overall objective of this study is to evaluate the safety and efficacy of fish oil omega-3-fatty acid supplementation in treating pediatric HAART-associated hypertriglyceridemia.
- Trial name
- NCT00691288
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- The Hospital for Sick Children
Non Alcoholic Fatty Liver Disease, Steatohepatitis
Genetic Effect on Omega 3 Fatty Acids for the Treatment of Fatty Liver Disease
To explore whether there is a different response to omega-3 fatty acid rich diet with respect to the hepatic fat fraction % (HFF), triglyceride, and ALT levels between the rs738409 minor allele (GG) and the common allele…
- Conditions
- Non Alcoholic Fatty Liver Disease, Steatohepatitis, Hypertriglyceridemia, Alanine Aminotransferase, Plasma Level of, Quantitative Trait Locus 1
- Trial name
- NCT01556113
- Testing
- Omega diet
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Hyperlipoproteinemia
Plasma Triglyceride Lipolysis in Multifactorial Chylomicronemia
Purpose: The mechanism of most of the multifactorial chylomicronemia (MCM) remains elusive. In order to decipher the mechanisms involved in the occurrence of this disease, plasma TG lipolysis characteristics will be monitored for…
- Trial name
- NCT02933138
- Volunteers
- 62 people
- Sponsor
- Hospices Civils de Lyon
Hypertriglyceridemia
Trial of Lovaza in Adolescents With Mild to Moderately Elevated Triglycerides
The investigators will conduct a randomized clinical trial to evaluate the efficacy of Lovaza (formerly known as Omacor) in reducing triglyceride levels in youth ages 10-19 years old whose baseline triglycerides range from 150…
- Trial name
- NCT00672633
- Testing
- Lovaza
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Boston Children's Hospital
Hypertriglyceridemia
Fat Tolerance From Lipid Emulsion Infusion Packaged in Glass or Plastic
This will be a prospective, randomized trial to determine if differences exist in the tolerance of lipid injectable emulsions in the neonatal intensive care unit (NICU).
- Trial name
- NCT00278928
- Testing
- Liposyn III 20% (lipid infusion), Intralipid 20% (lipid infusion)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Beth Israel Deaconess Medical Center
Hypertriglyceridemia
Russian Extreme Hypertriglyceridemia Registry
The REGGI registry is a prospective, multicenter observational registry in Russia designed to collect data on patients with extreme hypertriglyceridemia (triglyceride levels ≥10 mmol/L).
- Trial name
- REGGI (NCT07508930)
- Where
- 6 sites in Russia
- Volunteers
- 500 people
- Sponsor
- Russian Cardiology Research and Production Center
Familial Hypertriglyceridemia
Stockholm hyperTRIglyceridemia REGister (STRIREG) Study
The STRIREG study is a retrospective longitudinal general population-based register study including all individuals who had had at least one plasma Tg measurement between 1st January 2000 and 31st December 2021 at Karolinska…
- Trial name
- STRIREG (NCT06104943)
- Testing
- Heredity for cardiovascular disease, Heredity for pancreatitis, Heredity for type 2 diabetes
- Volunteers
- 3,607,819 people
- Sponsor
- Region Stockholm
Basal Cell Carcinoma, Keratosis Palmaris et Plantaris
The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases
This is a continuing study which evaluates the long-term safety and efficacy of oral acitretin in an open manner in the treatment of psoriasis, cutaneous disorders of keratinization, multiple basal cell carcinomas and other…
- Conditions
- Basal Cell Carcinoma, Keratosis Palmaris et Plantaris, Psoriasis
- Trial name
- NCT00005660
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Hyperlipoproteinemia Type I, Hypertriglyceridemia
Orlistat for the Treatment of Type I Hyperlipoproteinemia
Patients with Type I Hyperlipoproteinemia (T1HLP) have a rare form of hypertriglyceridemia marked by significant chylomicronemia and recurrent episodes of acute pancreatitis.
- Trial name
- T1HLP (NCT02767531)
- Testing
- Orlistat
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Texas Southwestern Medical Center
Familial Partial Lipodystrophy Type 2
Study of Cortisol Metabolism in Familial Partial Lipodystrophy Type 2
Familial partial lipodystrophic syndromes are characterized by an increase in visceral adipose tissue and an atrophy of subcutaneous adipose tissue.
- Trial name
- LIPOCORT (NCT04845165)
- Testing
- Biopsy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Lille
Pediatric Homozygous Familial Hypercholesterolemia (HoFH), Severe Hypertriglyceridemia (HTG)
Compassionate Use of Evinacumab
Provide compassionate use of evinacumab
- Conditions
- Pediatric Homozygous Familial Hypercholesterolemia (HoFH), Severe Hypertriglyceridemia (HTG), Dysbetalipoproteinemia (DBL)
- Trial name
- NCT06500598
- Testing
- Evinacumab
- Sponsor
- Regeneron Pharmaceuticals
Cardiovascular Diseases, Atherosclerosis
Genetic Determinants:Low HDL, High Triglycerides, Obesity
To conduct genetic studies of the metabolic syndrome characterized by very low levels of high density lipoprotein cholesterol (HDL-C), hypertriglyceridemia, and obesity.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Hypertriglyceridemia, Obesity
- Trial name
- NCT00049881
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Chronic Kidney Disease, Hypertriglyceridemia
Omega-3 Fatty Acid Supplementation in Children
Children with Chronic Kidney Disease (CKD) are at very high risk for cardiovascular morbidity and mortality. Hyper-lipidemia, a traditional risk factor for Cardiovascular Disease (CVD), occurs early in the progression of kidney…
- Trial name
- NCT01088776
- Testing
- n-3 Fatty Acid supplement
- Where
- Canada
- Volunteers
- 4 people
- Sponsor
- The Hospital for Sick Children