Clinical trials: Hyponatraemia
Hypervolemic and Euvolemic Hyponatremia
Samsca Post Marketing Surveillance Study
This Post-Marketing Surveillance will be conducted in accordance with the local regulation of New Drug Re-examination. The surveillance will be conducted for 6 years of the re-examination period (01Sep2011~31Aug2017).
- Trial name
- Samsca PMS (NCT02722863)
- Where
- 4 sites in South Korea
- Volunteers
- 908 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Hyponatremia
Study of the Safety and Effectiveness of SAMSCA® (Tolvaptan) in Children and Adolescents With Euvolemic or Hypervolemic Hyponatremia
The purpose of this trial was to demonstrate that tolvaptan effectively and safely increases and maintains serum sodium concentrations in children and adolescent participants with euvolemic or hypervolemic hyponatremia.
- Trial name
- NCT02012959
- Testing
- Tolvaptan
- Where
- 7 sites in United States, Italy and 1 more
- Volunteers
- 9 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Hyponatremia, Hypernatremia
Hypotonic Versus Isotonic Parenteral (HIP) Fluid Trial
Children who are undergoing surgery need intravenous fluids to prevent dehydration and maintain their electrolyte balance. The current standard of care in these children is to use a fluid which is low in sodium (hypotonic fluid).
- Trial name
- NCT00734214
- Testing
- 0.9% NaCl, 0.45%NaCl
- Where
- Canada
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Hyponatremia
Maintenance Intravenous Fluids in Children
Hyponatraemia arises in between 20% and 45% of sick hospitalized children. An important reason for this high incidence could be use of hypotonic fluids in sick children for maintenance fluid therapy.
- Trial name
- NCT00621348
- Testing
- Isotonic fluid, Hypotonic fluid
- Where
- India
- Volunteers
- 167 people
- Sponsor
- All India Institute of Medical Sciences
Hyponatremia
Relationship Between Heat Wave and Hyponatremia
The objective of this study is to explore the relationship between moderate to severe hyponatremia and heat.
- Trial name
- NCT02012660
- Testing
- Seasonality
- Where
- Switzerland
- Volunteers
- 28,734 people
- Sponsor
- University Hospital, Geneva
Hyponatremia
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children
The primary objective of this study is to compare the mean serum sodium at 48 hours following the initiation of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in children requiring maintenance IV fluid…
- Trial name
- NCT00632775
- Testing
- Hypotonic (0.45% NaCl/5% dextrose) IV maintenance fluids, Isotonic (0.9% NaCl/5% dextrose) IV maintenance fluids
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- The Hospital for Sick Children
Hyponatremia
A Study to Assess the Efficacy, Safety and Pharmacokinetics of Intravenous Conivaptan (Vaprisol®) in Pediatric Subjects With Euvolemic or Hypervolemic Hyponatremia
The objective of this study is to evaluate the efficacy, safety and pharmacokinetics of intravenous conivaptan in pediatric subjects with abnormally low concentration of sodium in blood.
- Trial name
- NCT01451411
- Testing
- Conivaptan hydrochloride
- Where
- 3 sites in United States, Colombia
- Volunteers
- 4 people
- Sponsor
- Cumberland Pharmaceuticals
Bronchiolitis, Seizures
Seizures in Infants Hospitalized in Pediatric Intensive Care Unit for Bronchiolitis
Bronchiolitis is the leading cause of pediatric intensive care unit admission in infants. Seizures during bronchiolitis may be a neurological complication of respiratory viruses but also of the treatments.
- Conditions
- Bronchiolitis, Seizures, Hyponatremia
- Trial name
- BRONCHIOLITIS (NCT04022486)
- Testing
- Incidence, management and risk factors of seizure
- Where
- France
- Volunteers
- 805 people
- Sponsor
- Hospices Civils de Lyon
Dengue Fever, Children
New Tools for Predicting Capillary Leak Shock During Dengue Fever
Evaluate the prognostic value of different methods (Osmometry / clinical-biological score) compared to the occurrence of capillary leak shock during dengue fever.
- Conditions
- Dengue Fever, Children, Adults
- Trial name
- PrediDengue (NCT04422782)
- Testing
- For each routine sample, an additional tube will be collected to measure the osmotic pressure in the blood and urine
- Where
- France
- Volunteers
- 342 people
- Sponsor
- Centre Hospitalier de Cayenne
Hyponatremia, SIADH
The Clinical and Laboratory Characteristics of Recurrent Drug- Related Hyponatremia
The aim of this study is to identify factors associated with hyponatremia among patients hospitalized in the internal medicine ward. Consequtive patients hospitalized because of hyponatremia will be recruited.
- Trial name
- 0597-10-HMO (NCT01509170)
- Where
- 2 sites in Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Diarrhoea
Introduction of Hypo-osmolar ORS for Routine Use
The World Health Organization has very recently recommended the routine use of a hypo-osmolar ORS in the management of diarrhoeal diseases.
- Trial name
- NCT00244777
- Testing
- Hypo-osmolar ORS
- Where
- Bangladesh
- Volunteers
- 75,000 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Hyponatremia, Hypernatremia
Comparison of Isotonic Versus Hypotonic Fluids in Neonates for Maintenance Fluid Therapy After Surgery
The goal of this clinical trial is to determine if isotonic or hypotonic fluids are more effective in maintaining serum sodium levels in neonates undergoing maintenance fluid therapy post-surgery.
- Conditions
- Hyponatremia, Hypernatremia, Postoperative Care in Neonates, Edema
- Trial name
- NCT06484608
- Testing
- Isotonic Saline with Dextrose
- Where
- Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Rawalpindi Medical College
Hyponatremia, Covid19
HYPONATREMIA IN COVID-19 PATIENTS
SYSTEMIC INFLAMMATION HAS BEEN ASSOCIATED WITH SEVERE COVID-19. HYPONATREMIA CAN RESULT FROM INFLAMMATION DUE TO NON-OSMOTIC STIMULI FOR VASOPRESSIN PRODUCTION.
- Conditions
- Hyponatremia, Covid19, Corona Virus Infection
- Trial name
- NCT04493268
- Where
- Argentina
- Volunteers
- 250 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Hyponatremia
Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia
The purpose of this study is to determine if isotonic solutions reduce the risk of hospital acquired hyponatremia compared with hypotonic solutions.
- Trial name
- NCT01909336
- Testing
- 0.3% Saline in 3.3% dextrose, 0.45% Saline in 5% dextrose, 0.9% Saline in 5% dextrose
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Hyponatremia
0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Critically Ill Children
The primary objective of this study is to compare the mean serum sodium after 48 hours of therapy with either 0.45% NaCl/dextrose 5% or 0.9% NaCl/dextrose 5%, in critically ill children requiring IV maintenance fluid…
- Trial name
- NaCrICh (NCT01301274)
- Testing
- hypotonic, isotonic
- Where
- Argentina
- Volunteers
- 66 people
- Sponsor
- Hospital General de Niños Pedro de Elizalde
The Patients Suffered With Sellar Diseases, The Fluid and Electrolyte Imbalance Happened After Surgery
Disturbance of Water and Sodium Metabolism After Surgery of Sellar Lesions, and Correspond Clinical Strategy
The fluid and electrolyte imbalance (FEI) is pretty common encountered during the clinical process of patients suffered sellar lesions.
- Trial name
- NCT01406041
- Testing
- Chemical and physical detection
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Southern Medical University, China
Hyponatremia, Dengue
Prevalence of Hyponatremia in Dengue Infected Patients: Relationship With Systemic Inflammation.
Prospective cohort study in patients with newly diagnosed dengue infection at Hospital Posadas in Argentina, between January 1, 2016, and November 1, 2023. Diagnosis was confirmed by IgM serology or PCR.
- Conditions
- Hyponatremia, Dengue, Inflammation
- Trial name
- HINDIP (NCT06109532)
- Testing
- hyponatremia
- Where
- 2 sites in Argentina
- Volunteers
- 530 people
- Sponsor
- Hospital Nacional Profesor Alejandro Posadas
Hyponatremia
Comparison of Ringer Lactate and Isotonic Acetate Solution as Perioperative Maintenance Fluid for Children
In children fluids are supplemented during surgery to provide volume, to maintain blood glucose levels, electrolyte balance and to meet the ongoing fluid losses during surgery.
- Trial name
- NCT02936167
- Testing
- Ringer Lactate, Plasmalyte
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
SIADH, Non-SIADH Hyponatremia
Post-Authorisation Safety Study of Samsca (Tolvaptan) Used in Routine Medical Practice
A Drug Utilisation Survey is performed to monitor and document the drug utilisation patterns of Samsca in routine medical practice.
- Conditions
- SIADH, Non-SIADH Hyponatremia, Non-Hyponatremia
- Trial name
- NCT01228682
- Testing
- Tolvaptan
- Where
- 47 sites in Denmark, Germany and 5 more
- Volunteers
- 200 people
- Sponsor
- Otsuka Frankfurt Research Institute GmbH
Hyponatremia, Premature
Early Sodium Intake in Preterm Newborns
Hyponatremia is a common complication among preterm infants, renal losses of sodium contribute to the development of hyponatremia in preterm newborns. Sodium imbalances impact in newborns outcome.
- Trial name
- NCT04035564
- Testing
- Sodium < 1mEq/kg/day, Sodium 5mEq/kg/day
- Where
- Mexico
- Volunteers
- 52 people
- Sponsor
- Hospital del Niño "Dr. Federico Gomez Santos"