Clinical trials: ICG (Indocyanine Green)
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Pulmonary Sequestration, Congenital Pulmonary Airway Malformation
Atomized Inhalation ICG for Treatment of Congenital Lung Malformations
To investigate the safety and effectiveness of preoperative aerosol inhalation ICG solution for thoracoscopic accurate resection of congenital lung malformations in children.
- Conditions
- Pulmonary Sequestration, Congenital Pulmonary Airway Malformation, Indocyanine Green, Thoracoscopic Surgery
- Trial name
- NCT06302985
- Testing
- atomized inhalation ICG before thoracoscope pneumonectomy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Jiexiong Feng
Bone Tumor
Utility of ICG in Benign Bone Tumors
Patients with a biopsy-proven benign bone tumor for which standard of care is intralesional operative management will receive a weight-appropriate IV dose of indocyanine green (ICG, FDA-approved) the day prior to surgery during…
- Trial name
- NCT05075889
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Calculous Cholecystitis, Laparoscopic Cholecystectomy
Using Indocyanine Green (ICG) to Outline Biliary Tree During Laparoscopic Cholecystectomy
The current study shows that Indocyanine green (ICG)-fluorescence cholangiography can be useful in identifying the extrahepatic biliary anatomy during Calot's triangle dissection.
- Trial name
- ICG (NCT06629415)
- Testing
- Indocyanine Green, Indocyanine Green Drug
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Theodor Bilharz Research Institute
Pediatric Renal Tumor, Metastatic Osteosarcoma
Indo-cyanine Green (ICG) in Paediatric Oncology MIS
Indo-cyanine green (ICG) is a dye that has been used for a variety of adult and paediatric uses since 1956. Over the past few years, near infrared (NIRF) technology has been developed which allow is use as a fluorescence agent…
- Conditions
- Pediatric Renal Tumor, Metastatic Osteosarcoma, Metastatic Ewing Sarcoma, Pulmonary Metastasis
- Trial name
- NCT04854018
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Childhood Thyroid Gland Carcinoma, Thyroid Diseases
Fluorescence Imaging of the Parathyroid Glands of Children
The aim of this study is to develop a standardized and user-independent imaging workflow model for autofluorescence and quantified fluorescence angiography with Indocyanine Green (ICG) of the parathyroid glands of children.
- Trial name
- FLUOPATCH (NCT05917067)
- Testing
- Fluorescence imaging of the parathyroid glands of children
- Where
- 3 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Torsion Testis, Scrotum Disease
Is ICG Imaging Safe and Accurate to Predict Testicular Torsion?
Testicular torsion is a time critical condition for children and young people (CYP). It is difficult to diagnose without an operation. Missing it means the child will lose a testicle.
- Trial name
- NCT07545278
- Testing
- Indocyanine green fluorescence injection and near infra red spectroscopy image capture
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Post-hemorrhagic Hydrocephalus (PHH)
Assessing CSF Flow Dynamics in Pediatric Hemorrhagic Hydrocephalus
The purpose of this study is to evaluate the safety and efficacy of ventricular microdosing of indocyanine green (ICG) in order to assess cerebrospinal fluid (CSF) ventricular dynamics and extracranial CSF outflow using…
- Trial name
- NCT06994949
- Testing
- fCTOT cap, NIRF planar imaging, ICG
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Eva Sevick
Pterygium
ICG Angiography in Amniotic Membrane Graft and Conjunctival Autograft After Pterygium Excision
To evaluate graft vascularization and compare the vascularization patterns of conjunctival autografts with amniotic membrane grafts to better understand the factors involved in pterygium recurrence.
- Trial name
- NCT00383825
- Testing
- Anterior segment indocyanine green angiography
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Baskent University
Thyroid Cancer, Thyroid Carcinoma, Papillary
Near-infrared Fluorescence With Indocyanine Green for Identification of Sentinels and Parathyroids During Thyroidectomy
Indocyanine green (ICG) is a water-soluble organic dye that is cleared totally through the hepatobiliary system. It has a half-life of 3-4 mins, which allows repeated applications.
- Conditions
- Thyroid Cancer, Thyroid Carcinoma, Papillary, Thyroid Metastases, Thyroid Neoplasms
- Trial name
- NCT04424485
- Testing
- Total thyroidectomy (TT), Central lymph node dissection (CLND), Sentinel lymph node (SLN) bopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Umraniye Education and Research Hospital
Tracheo-Esophageal Fistula with Atresia of Esophagus
Use of Indocyanine Green During Primary Repair of Oesophageal Atresia and Distal Tracheo-oesophageal Fistula
This study aims to look at babies having a primary or delayed primary oesophageal repair for OA with dTOF to evaluate if using Indocyanine green (ICG) and near infrared fluorescence (NIRF) can decrease the rates of anastomotic…
- Trial name
- iTOF (NCT05735964)
- Testing
- Indocyanine green
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
NEC, Atresia
Safety and Feasibility of Indocyanine Green Fluorescence for Intraoperative Assessment of Intestinal Perfusion in Young Infants and Neonates
The goal of this clinical trial is to test the use of the SPY-PHI device for the purpose of ICG-mediated intestinal perfusion visualization during gastrointestinal surgery in neonates and young infants (<3 months old) undergoing…
- Conditions
- NEC, Atresia, Malrotation, Intestinal Perforation
- Trial name
- IMAGINE (NCT05734118)
- Testing
- Perfusion assessment by means of the SPY-PHI camera
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Anastomotic Leak
The Impact of Indocyanine Green-enhanced Fluorescence Imaging on Bowel Transection in Left-sided Colorectal Resection
The aim of this study was to evaluate the impact of fluorescence imaging on the location of colorectal transection lines based on evaluation of perfusion with indocyanine green, how it's going to affect surgical planning and its…
- Trial name
- NCT02669485
- Testing
- indocyanine green, Fluorescence imaging
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Acute Cholecystitis
A Prospective Cohort of Emergent Laparoscopic Cholecystectomy in PUMCH
A prospective cohort study comparing the surgical outcome of patients who underwent emergent laparoscopic cholecystectomy guided by indocyanine green cholangiography (ELC-ICGC) versus conventional laparoscopic operation.
- Trial name
- ELC-PUMCH (NCT06552949)
- Testing
- Emergent laparoscopic cholecystectomy guided by ICG cholangiography (ELC-ICGC)
- Where
- China
- Volunteers
- 750 people
- Sponsor
- Peking Union Medical College Hospital
Intestinal Atresia, Necrotizing Enterocolitis
The Role of Indocyanine Green Angiography Fluorescence on Intestinal Resections in Pediatric Surgery.
Background: Intestinal resections are commonly performed in the pediatric population. Perfusion of the bowel is one of the most important factors determining the viability of an intestinal anastomosis.
- Conditions
- Intestinal Atresia, Necrotizing Enterocolitis, Hirschsprung Disease, Gastroschisis
- Trial name
- NCT04020939
- Testing
- SPY imaging, Indocyanine Green
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Thyroid Surgery
Quantitative Intra-operative Assessment of Parathyroid Perfusion Using Indocyanine Green (ICG) Fluorescence Imaging
This single-center, prospective, three-phase observational cohort quantifies the relationship between indocyanine green (ICG) fluorescence and early parathyroid function.
- Trial name
- NCT07010341
- Testing
- ntra-operative Indocyanine Green (ICG) Fluorescence Quantification
- Where
- 2 sites in China
- Volunteers
- 210 people
- Sponsor
- Fujian Medical University
Bone Neoplasms, Soft Tissue Neoplasms
Investigation Into the Safety and Efficacy of ICG-Labeled Fluorescence Imaging Technology in Guiding the Resection of Bone and Soft Tissue Tumors
Investigate the application protocol, feasibility, and efficacy of indocyanine green (ICG)-assisted near-infrared (NIR) fluorescence-guided resection in bone and soft tissue tumors.
- Trial name
- ICG-BST (NCT06979115)
- Testing
- Indocyanine green (ICG)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Guangdong Provincial People's Hospital
Endometrial Cancer, Vulvar Cancers
The Effect of Dose and Storage Conditions of Indocyanine Green on Efficacy and Cost in Sentinel Lymph Node Mapping in Gynecological Cancer
This research will determine the impact of optimizing dosage and storage conditions for indocyanine green on health outcomes and will contribute to improving treatment processes in gynecological cancers.
- Conditions
- Endometrial Cancer, Vulvar Cancers, Cervical Cancer, Indocyanine Green (ICG)
- Trial name
- DOSTCONICG (NCT07380698)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Solid Tumor
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
The purpose of the study is to find out the usefulness and safety of a dye called Indocyanine Green (ICG for short). This dye will be used to help the surgeon find lymph nodes draining solid tumors inside the abdomen that need to…
- Trial name
- NCT05645523
- Testing
- Indocyanine Green
- Where
- 3 sites in United States
- Volunteers
- 35 people
- Sponsor
- St. Jude Children's Research Hospital
Breast Cancer
Assessment of Breast Cancer-Related Arm Lymphedema
Lymphedema is a serious complication of breast cancer treatment. Reported prevalence of lymphedema following treatment for breast cancer varies, ranging from 7-45%.
- Trial name
- NCT03978754
- Testing
- ICG lymphography、CM、VD、Bioelectrical impedance technology、self-report, Bioelectrical impedance technology、CM
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Peking University People's Hospital