Clinical trials: Immune Development
Effect of Breastfeeding on Maternal and Child Health Outcomes
Promotion of Breastfeeding Intervention Trial
The overall goal of the PROBIT study is to investigate the influence of a randomized breastfeeding promotion intervention designed to increase the duration and exclusivity of breastfeeding ("the breastfeeding promotion…
- Trial name
- PROBIT (NCT01561612)
- Testing
- Breastfeeding promotion and support
- Where
- Belarus
- Volunteers
- 17,046 people
- Sponsor
- Harvard Pilgrim Health Care
Cancer, Lymphoma
A Study Of Remote Patient Monitoring (RPM) Program For Cancer Patients Initiating Cancer-directed Therapy
This clinical trial develops and studies whether using a new remote patient monitoring (RPM) program [Smart Health Integration for Early Life-saving Detection (SHIELD)] in cancer practices helps manage infectious complications…
- Trial name
- NCT07810400
- Testing
- Smart Phone Application-based Intervention - SHIELD, AION TempShield, Questionnaires
- Where
- United States
- Volunteers
- 470 people
- Sponsor
- Mayo Clinic
HIV/AIDS
Development of a Couple-Based Mobile Health Intervention for Enhancing HIV Care Engagement Outcomes (N'Gage)
HIV/AIDS among Black men is a US public health crisis, emphasizing the urgency for increased research focus and intervention development.
- Trial name
- N'Gage (NCT03100643)
- Testing
- mHealth N'Gage mobile application
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Type 1 Diabetes, Puberty: >Tanner 2 Breast Development or Testis >4ml
Rosiglitazone and Insulin in T1DM Adolescents
Type 1 Diabetes is the most common life-long disorder with onset in childhood. Patients need insulin injections, blood sugar monitoring several times each day, and adhere to a strict diet.
- Trial name
- NCT00372086
- Testing
- Rosiglitazone
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The University of New South Wales
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Dermatitis, Atopic
Atopic Dermatitis in Atopy Predisposed Infants
The primary objective of this study is to investigate the effectiveness of a standardized skin care regimen using a milk lotion once daily and a bathing addendum as needed during the first 52 weeks of life on the development of…
- Trial name
- ADAPI (NCT02906475)
- Testing
- standardized skin care regimen
- Where
- Germany
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Asthma, Eczema
Bacille Calmette-Guérin (BCG) Vaccine and Atopy
The prevalence of asthma and allergic diseases is increasing worldwide. Infections and vaccinations in childhood may have an impact on the subsequent development of asthma and allergy.
- Conditions
- Asthma, Eczema, Food Hypersensitivity
- Trial name
- NCT01420705
- Where
- Guinea-Bissau
- Volunteers
- 487 people
- Sponsor
- Bandim Health Project
HIV Infections, Nutrition Poor
Supplementation Trial of KOKO Plus Among HIV Exposed Children in Accra
The overall aim of the research is to conduct a randomised controlled trial of KOKOPlus in young HIV exposed children attending HIV clinics in Accra, Ghana to test the effectiveness of KOKOPlus over a period of 6 months to…
- Conditions
- HIV Infections, Nutrition Poor, Child Development
- Trial name
- NCT04995874
- Testing
- KOKOPlus protein and micronutrient powder
- Where
- 6 sites in Ghana
- Volunteers
- 649 people, healthy volunteers welcome
- Sponsor
- Noguchi Memorial Institute for Medical Research
HIV, AIDS
The DC Cohort Longitudinal HIV Status Neutral Study
The goal of the DC Cohort is to establish a clinic-based city-wide longitudinal cohort that will describe clinical outcomes, and improve the quality of care for patients diagnosed with Human Immunodeficiency Virus/Acquired Immune…
- Trial name
- DC Cohort (NCT01206920)
- Where
- 14 sites in United States
- Volunteers
- 19,000 people, healthy volunteers welcome
- Sponsor
- George Washington University
Preterm Birth, Developmental Delay
The Alkmaar MLPTI Cohort Study: Outcomes at 9 Years
Objective of the study: To examine cognition, motor function, executive functions, speech and language development, behaviour, psychosocial functioning,academic achievement, physical morbidities and growth of MLPTI at the age of…
- Conditions
- Preterm Birth, Developmental Delay, Growth Delay
- Trial name
- NCT05990582
- Testing
- CBCL, SDQ, CCC-2-NL
- Where
- Netherlands
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Noordwest Ziekenhuisgroep
Diabetes, Endocrine System Diseases
Evaluating Innovations in Transition From Pediatric to Adult Care - The Transition Navigator Trial
The Transition Navigator Trial (TNT) is a pragmatic randomized controlled trial evaluating the effectiveness of usual care plus a patient navigator service versus usual care plus newsletters and other educational materials, to…
- Conditions
- Diabetes, Endocrine System Diseases, Gastro-Intestinal Disorder, Neuro-Degenerative Disease
- Trial name
- TNT (NCT03342495)
- Testing
- Patient Navigator, Usual Care
- Where
- 3 sites in Canada
- Volunteers
- 337 people
- Sponsor
- University of Calgary
Autism Spectrum Disorder, Autism
GAIP ASD Research Study
This clinical research study evaluates the safety and preliminary effects of AdiaVita (umbilical cord blood-derived stem cells and exosomes) combined with glutathione versus glutathione alone in people aged 3 and older with…
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autism Spectrum Disorder (ASD)
- Trial name
- NCT07622316
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Greater Atlanta Integrative Pediatrics
HIV, HIV - Human Immunodeficiency Virus
Intervention to Reduce HIV Related Stigma Among Pregnant and Postpartum Women
Purpose of this Study: The main purpose of this study is to adapt an existing evidence-based intervention, Project Accept Post-Test Support Services (PTSS) Module 3, specifically for pregnant and postpartum women living with HIV…
- Conditions
- HIV, HIV - Human Immunodeficiency Virus, Postpartum, Pregnancy
- Trial name
- WAT (NCT07064928)
- Testing
- Adapted Project Accept's Post-Test Support Services (PTSS) Module 3
- Where
- Ghana
- Volunteers
- 175 people
- Sponsor
- University of California, San Francisco
Child Development, Growth
Health and Early Life Microbiota
The aim of this cohort is to identify environmental, lifestyle and genetic factors that modify the human intestinal microbiota development during the first years of life, and to identify early microbiota features that associate…
- Conditions
- Child Development, Growth, Allergy, Overweight
- Trial name
- HELMi (NCT03996304)
- Where
- Finland
- Volunteers
- 1,055 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Healthy Children
To Investigate the Effects of Bifidobacterium Animalis Subsp. Lactis XLTG11 on Growth and Development, Incidence of Allergy and Immune Function in Infants
This study is a 180-day randomized, double-blind, placebo-controlled trial involving healthy infants and young children under 3 years of age with elevated allergy risk.
- Trial name
- NCT07490587
- Testing
- Probiotic
- Where
- 2 sites in China, Malaysia
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Min-Tze LIONG
Traumatic Brain Injury, Cerebral Palsy
Real World Outcomes of Intranasal MuSE Exosomes and Stem Cells in Neurological Regenerative Therapy
This prospective observational study collects real world data on participants receiving regenerative therapies administered internationally and delivered intranasally via the Kurve Therapeutics ViaNase device.
- Conditions
- Traumatic Brain Injury, Cerebral Palsy, Hypoxic Ischemic Encephalopathy, Neurologic Disorders
- Trial name
- MuSE-INSIGHT (NCT07521384)
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Healing Hope International
Type 1 Diabetes
Development of Novel Biomarkers for the Early Diagnosis of Type 1 Diabetes
The purpose of this study is to measure the levels of certain substances (biomarkers) in the body that may indicate the triggers of Type 1 Diabetes, to find a better way to diagnose the disease, as well as to follow its…
- Trial name
- HONEY (NCT04164966)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Diabetes Mellitus, Type 1
Type 1 Diabetes and the Brain in Children
The investigators have previously studied a group of young children with T1D using brain MRI, age-appropriate neurocognitive testing and continuous glucose monitoring, followed for 18 months.
- Trial name
- NCT02351466
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Asthma
Study and Development of Application Models of "Therapeutic Education to the Patient" (TEP) in Asthmatic Children
It is an interventional prospective study. The study will assess the intervention of the "Therapeutic Education to the Patient (TEP)" on the quality of life in asthmatic children.
- Trial name
- TEP (NCT02636920)
- Testing
- Therapeutic Education to the Patient (TEP)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Stefania La Grutta, MD
Severe Autoimmune Encephalitis
Risk Prediction Model for Severe Autoimmune Encephalitis
A prospective study aims to establish a multicenter clinical diagnosis and treatment database for patients with autoimmune encephalitis (AE).
- Trial name
- NCT06697678
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 1,000 people
- Sponsor
- Xuanwu Hospital, Beijing