Clinical trials: Immune Function
Asthma Attack, Lung Function
Cost Effective Air Filtration Intervention in Low-Income Housing to Reduce Asthma Morbidity
This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC).
- Conditions
- Asthma Attack, Lung Function, Airway Inflammation
- Trial name
- NCT07116460
- Testing
- Austin Air Cleaner
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Columbia University
Infant Growth
Growth and Health Efficacy of Novel Infant Formula : A Randomized Trial
Randomized, controlled study consisting of three parallel arms to investigate the effects of novel infant formula on growth, gut health, immune function, and sleep status in healthy infants and young children aged 12-18 months.
- Trial name
- NCT07534735
- Testing
- Investigational Formula 1, Investigational Formula 2
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Biostime (Changsha) Nutrition Foods Limited
Lupus Erythematosus, Systemic, Gastrointestinal Microbiome
Assessment of Cognitive Function and Gut Microbiota Analysis in Real World Patients With Lupus Cerebrovascular Disease
Based on clinical manifestations, laboratory data and intestinal microflora detection, the cognitive function characteristics of patients with systemic lupus erythematosus and cerebrovascular disease and its relationship with…
- Trial name
- NCT05636670
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Asthma
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).
- Trial name
- MODIFY (NCT07456033)
- Testing
- Depemokimab
- Where
- 17 sites in United States, United Kingdom
- Volunteers
- 456 people
- Sponsor
- GlaxoSmithKline
Intellectual Disability, Mild
Evaluation of CO-OP for Adolescents With Mild Intellectual Disability
Intellectual disability (ID) affects a person throughout life and includes difficulties to manage what is expected in everyday life based on age.
- Trial name
- CO-OPIF (NCT06691698)
- Testing
- The Cognitive Orientation to Daily Occupational Performance Approach
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Acute Lymphoblastic Leukemia, Pediatric
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.
Long non-coding RNAs (lncRNAs) are a class of biomarkers of crescent interest in the hematologic and oncologic field. They do not encode proteins and can alter gene expression by acting on different steps of regulation, including…
- Trial name
- NCT06334835
- Testing
- lncRNA signature analyses
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS SYNLAB SDN
Multiple Sclerosis
Evaluating Alemtuzumab as a Treatment in Stabilizing Neurocognitive Function In Relapsing Remitting Multiple Sclerosis Patients
The main purpose of this research study is to investigate how well a medicine (alemtuzumab) works in treating MS-related cognitive problems (e.g., attention, memory, speed of thinking).
- Trial name
- CAMA-2 (NCT01333358)
- Testing
- Alemtuzumab
- Volunteers
- 30 people
- Sponsor
- Central Texas Neurology Consultants
Atopic Dermatitis, Eczema
The Effects of Emollient Therapy on the Skin Barrier
The goal of this study is to better understand what effect emollients (moisturizers) have on the skin in young children and adults.
- Trial name
- EES (NCT01291940)
- Testing
- Pediatric Moisturizer, Adult Moisturizer
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Asthma Acute, Asthma in Children
User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients
The primary goal of this proposal is to use an in-home, smartphone-enabled, hand-held spirometer to determine the FEV1% predicted ranges that predict the Yellow Zone threshold.
- Conditions
- Asthma Acute, Asthma in Children, Asthma Chronic, Asthma Attack
- Trial name
- NCT03642418
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Childhood Asthma
More Relaxation by Deep Breath on Methacholine
Deep inhalation (DI) dilates normal airway precontracted with methacholine. The fact that this effect is diminished or absent in asthma could be explained by the presence of bronchial inflammation.
- Trial name
- SouProvocBro (NCT03696602)
- Testing
- bronchial provocation test
- Volunteers
- 78 people
- Sponsor
- Central Hospital, Nancy, France
Atopic Dermatitis (AD)
Effect of Partially Hydrolyzed Formula With Synbiotics on Skin Barrier Function
The main purpose of this study is to assess the efficacy of a partially hydrolyzed formula with synbiotics in halting one of the first steps of the allergic march (atopic dermatitis) in infants at risk of allergy.
- Trial name
- SPHINX (NCT06943469)
- Testing
- Test formula, Control formula
- Where
- 25 sites in Belgium, France and 3 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Inflammation
Effect of Probiotic Supplementation on Immune Function in Healthy Infants
The purpose of this study is to understand how a probiotic might change the immune response of healthy infants.
- Trial name
- ProBoost (NCT01542320)
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Emory University
Acute Lymphatic Leukemia, Lymphoma
More Than Just X-Rays - Imaging of Chemotherapy-induced Morphological and Functional Cardiovascular and Lung Changes After Childhood ALL and Other Cancers - a Monocentric Late Effects Study (MaximALL)
In this study, we investigate the cardiopulmonary health of survivors who underwent cancer treatment for acute lymphoblastic leukemia (ALL) or lymphoma during childhood, compared with healthy controls.
- Trial name
- MaximALL (NCT07705178)
- Testing
- QOL assessment, Neuropsychological, Spirometry, DLCO measurement
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Acute Bronchiolitis, Asthma
Acute Bronchiolitis in Infants and Allergic Asthma
Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult. Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated…
- Conditions
- Acute Bronchiolitis, Asthma, Allergy
- Trial name
- NCT03915197
- Testing
- Pneumological evaluation
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Clermont-Ferrand
AIDS, Stress
Socioenvironmental Determinants of Psychological Functioning, Mental Health and AIDS in Mali
This project is a collaboration between the Centre Regional de Medecine Traditionnelle (CRMT) of the Malian National Institute of Public Health Research (INRSP) and the Section on Socioenvironmental Studies (SSES).
- Trial name
- NCT00339391
- Where
- Mali
- Volunteers
- 1,002 people
- Sponsor
- National Institute of Mental Health (NIMH)
Preterm, Surgery
An Exploratory Study of Arginine Supplementation and the Postoperative Immune REsponse
ASPIRE is a nutrition study focusing on the effect of arginine supplementation on immune function in postoperative infants. The investigators will explore the effect of current intravenous feeding (parenteral nutrition (PN))…
- Conditions
- Preterm, Surgery, Nutritional Deficiency, Immune System and Related Disorders
- Trial name
- ASPIRE (NCT05306925)
- Testing
- Arginine
- Where
- 2 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University of Liverpool
Type 1 Diabetes
Supporting Treatment Adherence Needs in Diabetes
There is an unmet treatment need for depressed adolescents with type 1 diabetes. To address this unmet need, we have designed a new, family-based, cognitive-behavioral intervention to reduce depressive symptoms, improve family…
- Trial name
- STAND (NCT01030471)
- Testing
- Family-based cognitive-behavioral treatment
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma
Lung Function of Asthmatic Children by Nebulized MgSO4
Asthma is a common chronic respiratory illness which results in frequent wheezing, cough,reduced quality of life. Standard treatment for asthma attack includes oxygen therapy, β2-agonists (e.g.
- Trial name
- NCT01799109
- Testing
- Magnesium Sulfate & albuterol, albuterol, magnesium
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
Juvenile Idiopathic Arthritis
OHRQoL Evaluation After Functional Therapy in JIA Patients
The aim of the study was to determine the changes in Oral Health-Related Quality of Life (OHRQoL) in patients with juvenile idiopathic arthritis (JIA) and temporomandibular joint (TMJ) disorders who underwent functional therapy…
- Trial name
- NCT03008681
- Testing
- Andresen functional removable orthodontic appliance
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Messina
Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia
Natural Killer Index From Hematopoietic Stem Cell Graft
Numerous studies about the potential role of NK alloreactive during a n hematopoietic stem cells graft are based on genotypical analyses of the KIR receptors and on genotypic incompatibilities between KIR and HLA for couple…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloblastic Leukemia, Chronic Myeloid Leukemia
- Trial name
- NCT00435864
- Testing
- Blood test
- Where
- France
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital