Clinical trials: Immune System Function
Prediabetes, Type 1 Diabetes
TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function
To evaluate the effect of Gluten Free Diet (GFD) on beta-cell function and glucose metabolism in subjects with one or several islet autoantibodies without and with dysglycemia at baseline.
- Trial name
- TEFA (NCT02605148)
- Testing
- Gluten free diet, Omega 3 fatty acid, Vitamin D
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University
Juvenile Idiopathic Arthritis (JIA)
Short-Term Effects of Intra-Articular Corticosteroid Injection on Knee Function in Juvenile Idiopathic Arthritis
The purpose of this study is to evaluate the short-term clinical effects of intra-articular corticosteroid injections on knee joint functions in children and adolescents diagnosed with Juvenile Idiopathic Arthritis (JIA).
- Trial name
- NCT07709026
- Testing
- Intra-articular Corticosteroid Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Necmettin Erbakan University
Klinefelter Syndrome, Thyroiditis, Autoimmune
Thyroid Function and Structure in Klinefelter Syndrome
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
- Conditions
- Klinefelter Syndrome, Thyroiditis, Autoimmune, Hypothyroidism
- Trial name
- THINKS (NCT05581147)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Roma La Sapienza
Thyrotoxicosis
Thiamine Supplement in Patients With Severe Hyperthyroidism
Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism.
- Trial name
- NCT02767245
- Testing
- Thiamine
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Ramathibodi Hospital
Type 1 Diabetes
Time Limited Eating in Type 1 Diabetes
This study is a randomized-control pilot study that aims to evaluate Time Limited Eating (TLE) in the pediatric T1D population, implemented within the first six months after diagnosis.
- Trial name
- TLET1D (NCT05031429)
- Testing
- Time Limited Eating
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's Hospital Los Angeles
Hodgkin Disease, Lymphoma, Non-Hodgkin
Functional Assessment of Cancer Therapy - Bone Marrow Transplant
Functional Assessment of Cancer Therapy - Bone Marrow Transplant
- Trial name
- FACT-BMT (NCT01490957)
- Testing
- Database
- Where
- Saudi Arabia
- Volunteers
- 113 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Type 1 Diabetes
Immune Function and the Progression to T1D
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune…
- Trial name
- NCT05899439
- Testing
- blood draw
- Where
- 3 sites in United States
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- University of Florida
Premature Birth, Bronchopulmonary Dysplasia
Assessment of Lung Structure and Function of Infants Born Prematurely
The purpose of this study is to evaluate the growth of the lung and how easily gas can be taken up by the lung in healthy infants born at full term without any breathing problems and infants born prematurely.
- Conditions
- Premature Birth, Bronchopulmonary Dysplasia, Asthma
- Trial name
- NCT00422305
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma, Wheezing
Lung Function and Structure in Healthy Infants and Infants With Recurrent Wheezing
Infants will be enrolled into this study in one of three groups. First, there will be a group of full term infants with no history of wheezing.
- Conditions
- Asthma, Wheezing, Infant
- Trial name
- NCT00507676
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Indiana University
Asthma, Obesity
The Analysis of BMI, Asthma Prevalence, and Lung Functions of Schoolchildren in Southern Taiwan
The prevalence of obesity and asthma has increased in recent decades. We investigated the relationship between body mass index (BMI) and lung function, and also tried to determine if asthma prevalence differs between obese and…
- Trial name
- NCT00629785
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Asthma
The Correlations of FeNO, Blood Eosinophils and Lung Function in Well-controlled Asthma
In Asthma, the levels of exhaled FeNO is correlated to sputum eosinophils particularly in the patient with poor controlled asthma or severe asthma.
- Trial name
- NCT04454385
- Testing
- Patients with well controlled asthma
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Hat Yai Medical Education Center
Allergic Conjunctivitis
The Role of Vitamin D in Corneal Epithelial Barrier Function, Ocular Microbiome, Ocular Inflammation, and Visual Acuity of Children With Allergic Conjunctivitis
A double-blind study to evaluate the role of vitamin D in corneal epithelial barrier function, ocular microbiome, ocular inflammation, and visual acuity of children with allergic conjunctivitis.
- Trial name
- NCT05839938
- Testing
- Vitamin D
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Rhinitis, Allergic, Perennial
A Study of GW685698X for the Treatment Of Perennial Allergic Rhinitis in Adolescents and Adults
The purpose of this study is to assess the effect of an aqueous nasal spray investigational compound compared to placebo on the hypothalamic pituitary adrenocortical (HPA) axis system in adolescents and adults 12 to 65 years of…
- Trial name
- NCT00116818
- Testing
- GW685698X aqueous nasal spray
- Where
- 2 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- GlaxoSmithKline
Asthma
Daily Monitoring of Exhaled Nitric Oxide in Asthmatic Patients
Previous studies have demonstrated that exhaled nitric oxide can be useful to monitor the efficacy of anti-inflammatory treatment as well as to predict a risk of asthma relapse in asthmatic patients.
- Trial name
- NCT01113853
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Universita di Verona
Asthma, Wheezing
Vitamin C Supplementation to Pregnant Smokers: Follow-up of 2 Randomized Trials Plus Changes in DNA Methylation
In a randomized clinical trial (RCT) published in JAMA, the investigators have provided evidence that vitamin C supplementation (500 mg daily during pregnancy) ameliorates the effects of maternal smoking during pregnancy on…
- Conditions
- Asthma, Wheezing, In Utero Nicotine, Pulmonary Function
- Trial name
- VCSIP-ECHO (NCT03206710)
- Testing
- No current intervention
- Where
- 2 sites in United States
- Volunteers
- 395 people
- Sponsor
- Oregon Health and Science University
Atopic Dermatitis, Eczema
The Effects of Emollient Therapy on the Skin Barrier
The goal of this study is to better understand what effect emollients (moisturizers) have on the skin in young children and adults.
- Trial name
- EES (NCT01291940)
- Testing
- Pediatric Moisturizer, Adult Moisturizer
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Asthma
Vitamin and Asthma Study
The study looks at how vitamin D supplement will improve the severity of asthma and lung function as well as biomarkers in asthmatic children.
- Trial name
- NCT01447173
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Augusta University
Arthrogryposis Multiplex Congenita, AMC-Arthrogryposis Multiplex Congenita
Arthrogryposis Multiplex Congenita in Pediatric Age: Correlation Between MUScular MRI and Functional Evaluation
The aim of our study is to evaluate the correlation between quantified fibro-adipous infiltration of muscles on MRI assessed by MERCURI Score and the functional abilities (deficiencies, activity limitations and social…
- Conditions
- Arthrogryposis Multiplex Congenita, AMC-Arthrogryposis Multiplex Congenita, Pediatric ALL
- Trial name
- AMUSE (NCT05393375)
- Testing
- No intervention
- Where
- France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Grenoble
Atopic Eczema
Softened Water for Eczema Prevention Pilot Trial
An outcome assessor-blinded pilot randomised controlled trial of an ion-exchange water softener for the prevention of atopic eczema in neonates, with an embedded mechanistic study
- Trial name
- SOFTER (NCT03270566)
- Testing
- Domestic ion-exchange water softener
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- King's College London
Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID)
Evaluation of Patients With Immune Function Abnormalities
This study will evaluate patients with abnormal immune function that results in recurrent or unusual infections or chronic inflammation.
- Conditions
- Chronic Granulomatous Disease (CGD), X-Linked Severe Combined Immune Deficiency (XSCID), Leukocyte Adhesion Deficiency 1 (LAD), Graft Versus Host Disease (cGvHD)
- Trial name
- NCT00128973
- Where
- United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)