Clinical trials: Immune System Function
Cerebral Palsy, Sensitivity
Daily Living Activities in Young Adults With Cerebral Palsy
This study explored the relationship between sensory function and occupational performance in young adults with Cerebral Palsy. Using standardized assessments, researchers compared tactile sensitivity and discrimination between…
- Conditions
- Cerebral Palsy, Sensitivity, Motor Skills Disorders, Activity, Motor
- Trial name
- Palsy202503 (NCT06909994)
- Testing
- individual assessments
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Burgos
HIV/AIDS, Cardiomyopathies
Ped HIV - Echo Study: Kenya
Background: In children and adults living with HIV, cardiomyopathy is a major source of comorbidity. Traditional echocardiographic measures are insensitive and consequently cardiomyopathy often goes undiagnosed until late stages…
- Trial name
- NCT03228966
- Testing
- Echocardiogram
- Where
- Kenya
- Volunteers
- 643 people
- Sponsor
- Duke University
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
Pediatric Atorvastatin in Diabetes Intervention Trial (PADIT)
The purpose of this study is to determine if Atorvastatin can improve blood vessel stiffness and blood vessel function in children 10-18 years old with Type 1 and Type 2 diabetes.
- Trial name
- NCT00130481
- Testing
- Atorvastatin 20 mg daily for 3 months
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Florida
Contact Dermatitis, Type 1 Diabetes Mellitus
Exploring Skin Barrier Function, Recurrence of Diabetes Device-Related Contact Dermatitis, and Evaluation of Hydrocolloid and Silicone-Based Patches for Its Prevention in Children and Adolescents With Type 1 Diabetes
The goal of this clinical trial is to ensure that contact dermatitis does not prevent any person with diabetes from accessing optimal diabetes treatment.
- Trial name
- StenoAD1 (NCT07767461)
- Testing
- hydrocolloid patch as patch used in the Sandwich method, Silicone-based patch as patch used in the Sandwitch method
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Steno Diabetes Center Copenhagen
Atopic Dermatitis
Evaluation of a Non-Invasive Device for Early Detection of Atopic Dermatitis Flares
This study will collect skin measurements from people with atopic dermatitis (AD) using the investigational Nevisense Go device.
- Trial name
- Detect-AD (NCT07645820)
- Testing
- Nevisense electrical impedance spectroscopy
- Where
- 13 sites in United States
- Volunteers
- 450 people
- Sponsor
- Castle Biosciences Incorporated
Copd, COVID-19
Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19
The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure…
- Conditions
- Copd, COVID-19, Asthma, Small Airways Disease
- Trial name
- PASSPORT (NCT04716023)
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Imperial College London
Asthma in Children, Telerehabilitation
COVID-19 Pandemic Asthma Child Telerehabilitation Yoga
In our study, yoga asana and pranayama practices, which will be applied by video call from computer or phone, will be advantageous in terms of time, transportation and access to asthmatic children whose anxiety and anxiety levels…
- Conditions
- Asthma in Children, Telerehabilitation, Yoga
- Trial name
- NCT05684926
- Testing
- Telerehabilitation yoga
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Bartın Unıversity
Type 1 Diabetes
A Phase I/II Trial to Preserve Residual Insulin Secretion in Children With Recent Onset Type 1 Diabetes by Giving Verapamil
The objective of this trial is first to evaluate safety and then the effect on preservation of residual beta cell function also clinical efficacy by treatment with Verapamil in children with recent onset Type 1 diabetes.
- Trial name
- VERADIAB-1 (NCT07199946)
- Testing
- Verapamil (Part A)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Johnny Ludvigsson
Diabetes Mellitus, Type 1
Carbohydrate Beta Cell Function and Glucose Control in Children With Diabetes
The goal of this clinical trial is to test the effects of a ketogenic diet on the progression and control of type 1 diabetes in children with newly diagnosed diabetes.
- Trial name
- NCT05899166
- Testing
- Ketogenic diet, food delivery and education, Standard diet, food delivery and education
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Boston Children's Hospital
Asthma, Pulmonary Function
Vitamin C to Decrease Effects of Smoking in Pregnancy on Infant Lung Function (VCSIP) Longer Term Follow Up
The overall aims of this protocol are to determine whether prenatal supplementation with vitamin C to pregnant smokers can improve pulmonary function at 10 years of age in their offspring.
- Conditions
- Asthma, Pulmonary Function, Wheezing, In Utero Nicotine
- Trial name
- VCSIP (NCT06106646)
- Testing
- No active intervention in this protocol (previously randomized to Vitamin C)
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- Oregon Health and Science University
Juvenile Idiopathic Arthritis
Accommodating Variable-Resistance Training in Patients With Juvenile Idiopathic Arthritis
This study was designed to investigate the effect of six weeks of accommodating variable-resistance training on muscle architecture, muscle strength, and functional performance in patients with juvenile idiopathic arthritis.
- Trial name
- NCT05805969
- Testing
- Accommodating variable-resistance training, Standard physical therapy
- Where
- Saudi Arabia
- Volunteers
- 58 people
- Sponsor
- Cairo University
Asthma
Effects of Papworth Breathing With or Without Bridge Pose Yoga in Asthma Patients
Asthma is a chronic condition causing airway inflammationandconstriction, leading to symptoms like shortness of breath, wheezing, andchest tightness.
- Trial name
- NCT07440953
- Testing
- Papeworth Breathing, Pap-worth Breathing + Bridge Pose Yoga
- Where
- Pakistan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Asthma Attack, Lung Function
Cost Effective Air Filtration Intervention in Low-Income Housing to Reduce Asthma Morbidity
This project will investigate the effectiveness of HEPA air cleaners in reducing indoor air pollution and improving asthma morbidity in children living in East Harlem, New York City (NYC).
- Conditions
- Asthma Attack, Lung Function, Airway Inflammation
- Trial name
- NCT07116460
- Testing
- Austin Air Cleaner
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Columbia University
Atopic Dermatitis, Food Allergy in Children
Preventing Atopic Dermatitis and ALLergies in Children
The primary objective is of the PreventADALL study is to test if primary prevention of allergic diseases is possible by simple and low cost strategies, and secondary to asses the impact of xenobiotic exposure and microbiota in…
- Conditions
- Atopic Dermatitis, Food Allergy in Children, Asthma, Rhinitis, Allergic
- Trial name
- PreventADALL (NCT02449850)
- Testing
- Food intervention, Skin care
- Where
- Norway
- Volunteers
- 2,701 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Acute Lymphoblastic Leukemia
Endothelial Function, Arterial Stiffness and Components
Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls.
- Trial name
- NCT01439217
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Asthma
Interleukin (IL)-13 as a Marker in Pediatrics Asthma
Asthma is a very common childhood chronic illness and is generally more severe in African Americans. The investigators attempted to determine whether a specific immune marker is associated with lung function and asthma severity.
- Trial name
- NCT00968305
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Rush University Medical Center
Diabetes Mellitus, Type 1
A Research Trial of Aralast in New Onset Diabetes (RETAIN)
The drug Alpha-1 Antitrypsin (AAT, Aralast NP) is being tested in this study as an anti-inflammatory drug (a medication that decreases inflammation, which is part of the body's normal ability to fight infection and respond to…
- Trial name
- RETAIN (NCT01183468)
- Testing
- Aralast NP 45 mg dose, Aralast NP 90 mg dose, Aralast NP 180 mg dose
- Where
- 15 sites in United States
- Volunteers
- 17 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dermatitis Atopic
Dupilumab-PEdiatric Skin Barrier Function and LIpidomics STudy in Patients With Atopic Dermatitis
Primary Objective: Evaluate changes in skin barrier function with transepidermal water loss (TEWL) assessed after skin tape stripping (STS) in predefined lesional skin in pediatric participants with moderate to severe atopic…
- Trial name
- PELISTAD (NCT04718870)
- Testing
- Dupilumab SAR231893
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sanofi
Asthma in Children
Effect of a Daily Text Reminder on Asthma Medication Use, Symptom Control, and Lung Function in Children
The goal of this clinical trial is to learn if a daily text reminder ("AdhasText") can help children with asthma use their inhalers regularly, control their symptoms, and improve their lung function.
- Trial name
- NCT07053839
- Testing
- Daily Text Reminder
- Where
- Peru
- Volunteers
- 64 people
- Sponsor
- ROXANA AZNARAN TORRES
Immune Thrombocytopenia
The Alteration of Macrophage Function in the Spleen Tissues From Patients With Primary Immune Thrombocytopenia
This project was undertaken by Qilu Hospital of Shandong University and other well-known hospitals in China. In order to report the alteration on the macrophage function in the spleen tissue of primary immune thrombocytopenia…
- Trial name
- ITP (NCT01869049)
- Where
- China
- Sponsor
- Shandong University