Clinical trials: Immunomodulation
Chronic Rhinosinusitis (CRS), Exacerbations
Effect of Pleuran on the Clinical Course of Patients With Chronic Rhinosinusitis
The goal of this clinical research is to learn if Imunoglukan P4H® as an add-on therapy to the standard of care treatment according to the EPOS guidelines (intranasal corticosteroids and saline irrigation) can help to prevent CRS…
- Conditions
- Chronic Rhinosinusitis (CRS), Exacerbations, Respiratory Tract Infections (RTI), Antibiotic Prophylaxis
- Trial name
- EPCCOR (NCT07460934)
- Testing
- Imunoglukan P4H® capsules
- Where
- 5 sites in Czechia, Slovakia
- Volunteers
- 85 people
- Sponsor
- Pleuran, s.r.o.
Atopic Dermatitis
Immunomodulation by OM-85 (Broncho-Vaxom) in Early AD
Clinical data suggest that treatment with OM-85, by inducing an early contact with bacterial extracts, could modulate the immunity of children with Atopic Dermatitis, and thus play an active role in the treatment of Atopic…
- Trial name
- NCT05222516
- Testing
- Broncho-Vaxom
- Where
- 28 sites in France, Germany and 2 more
- Volunteers
- 63 people
- Sponsor
- OM Pharma SA
Vasospastic Angina
Immunomodulatory Therapy & VSA
Vasospastic angina (VSA) is caused by brief spasms of the main coronary artery and its major branches, resulting in varying degrees of luminal occlusion.
- Trial name
- NCT06696807
- Testing
- glucocorticosteroids and/or intravenous immunoglobulin
- Where
- China
- Volunteers
- 71 people
- Sponsor
- Dao Wen Wang
Critical Illness
Effect of Immune-enhancing Enteral Nutrition on Immunomodulation in Critically Ill Patients
To determine whether high-protein (24% of total calorie from protein) enteral nutrition of immune modulating nutrients (eg, ω-3 fatty acids and antioxidants) enriched with β-glucan stimulates immune functions compared with…
- Trial name
- NCT02569203
- Testing
- standard enteral nutrition, high-protein enteral nutrition of immune modulating nutrients enriched with β-glucan, high-protein enteral nutrition of immune modulating nutrients without β-glucan
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Pompe Disease
Immune Modulation Therapy for Pompe Disease
The purpose of this study is to assess anti-recombinant human acid α-glucosidase (anti-rhGAA) antibody titers after treatment with immune modulation therapy in patients of Pompe disease.
- Trial name
- NCT02525172
- Testing
- Rituximab, intravenous immune globulin, Bortezomib
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Autism Spectrum Disorder, Autism
Adia Med of Winter Park LLC Autism Spectrum Disorder Research Study
This 12-month study tests whether AdiaVita (umbilical cord blood-derived stem cells and exosomes) plus glutathione improves autism symptoms more than glutathione alone in children ages 3-12.
- Conditions
- Autism Spectrum Disorder, Autism, ASD, Autism Spectrum Disorder (ASD)
- Trial name
- NCT07304440
- Testing
- Umbilical Cord Blood-Derived Stem Cells and Exosomes, Glutathione
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Adia Med of Winter Park LLC
Multiple Sclerosis
Rolipram to Treat Multiple Sclerosis
This study will evaluate the safety, tolerability, and effect of the drug Rolipram on multiple sclerosis (MS). It will examine whether Rolipram can dampen the part of the immune response believed to lead to MS and reduce disease…
- Trial name
- NCT00011375
- Testing
- Rolipram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Type 1 Diabetes
Clinical Application of Stem Cell Educator Therapy in Type 1 Diabetes
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes a deficit of pancreatic islet beta cells. Millions of individuals worldwide have T1D, and incidence increases annually.
- Trial name
- NCT04011020
- Testing
- Stem Cell Educator therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yong Zhao, MD, PhD
Type 1 Diabetes
Reversal of Type 1 Diabetes in Children by Stem Cell Educator Therapy
Type 1 diabetes (T1D) is an autoimmune disease that usually occurs in children and reduces their pancreatic islet beta cells and thereby limits insulin production.
- Trial name
- NCT01996228
- Testing
- Stem Cell Educator
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Throne Biotechnologies Inc.
DHA as Antioxidant Anti-inflammatory Immunomodulation , Overcome Cytokine Storm
Observational Study of Infants Fed on DHA (Breast Source or Milk Formula Source ) and Its Effects on Covid-19 Infected Infants and Severity
Observational Study of Infants Fed on DHA (Breast Source or Milk Formula Source ) and Its Effect on COVID-19 Severity Amr kamel khalil Ahmed ( drmedahmed@gmail.com ) Director of tuberculosis program Ghubera, public health…
- Trial name
- NCT05071690
- Where
- 2 sites in Egypt, Saudi Arabia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Saudi Arabia
Liver Cirrhosis, Severe Malnutrition
Granulocyte-Colony Stimulating Factor (G-CSF) as Optimizing Therapy for Pediatric Liver Transplantation
This study compares the effect of human recombinant Granulocyte-Colony Stimulating Factor (G-CSF) in pediatric patients with liver cirrhosis with a control group.
- Conditions
- Liver Cirrhosis, Severe Malnutrition, PELD, Undernutrition
- Trial name
- NCT04113317
- Testing
- G-CSF (Filgrastim)
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Melanoma (Skin)
Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop tumor cells from growing. Combining biological therapies with indomethacin and cyclophosphamide may kill more tumor cells.
- Trial name
- NCT00002535
- Testing
- aldesleukin, lymphokine-activated killer cells, therapeutic tumor infiltrating lymphocytes
- Where
- United States
- Sponsor
- St. Luke's Medical Center
Upper Respiratory Infections
Effects of Echinacea in Children
The goal of the this study is to determine if Echinacea purpurea stimulates the immune system in children. For the study, 40 healthy children, 6-11 years old will be randomized to receive Echinacea purpurea or placebo for 10 days…
- Trial name
- NCT00773435
- Testing
- Echinacea purpurea 100 mg/ml in liquid formulation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Washington
Pediatric Asthma, Critical Illness
Azithromycin for Critical Asthma - Pediatrics
The CR-AZI Study will assess the immunomodulatory effects of Azithromycin for pediatric Critical Asthma.
- Trial name
- CR-AZI Kids (NCT06223828)
- Testing
- Azithromycin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins All Children's Hospital
Type 1 Diabetes
Autologous Immunoregulatory Dendritic Cells for Type 1 Diabetes Therapy
The purpose of this study is to determine whether dendritic cells collected via leukapheresis and incubated with antisense DNA oligonucleotides and then injected back into the same subject will serve as modulators of the immune…
- Trial name
- NCT02354911
- Testing
- Immunoregulatory Dendritic Cells
- Sponsor
- DiaVacs, Inc.
HIV Infection
Subcutaneously Administered Interleukin-2 Therapy in HIV-Infected Patients
This is a Phase I dose-escalating safety study aimed at identifying the maximum tolerated dose (MTD) for an outpatient regimen while exposing the minimum number of patients to a dose less than MTD.
- Trial name
- NCT00001357
- Testing
- Interleukin-2
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dilated Cardiomyopathy, Heart Failure
Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy
The pathogenesis of dilated cardiomyopathy (DCM) leading to heart failure is closely associated with autoimmunity dysfunction. A few studies represented that Qiliqiangxin capsule, a Chinese medicine, could enhance heart function…
- Trial name
- QLQX-DCM (NCT01293903)
- Testing
- Qiliqiangxin capsule
- Where
- China
- Volunteers
- 374 people
- Sponsor
- Huazhong University of Science and Technology
Diarrhea, Constipation
Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation
The balance between immunogenic and tolerogenic activities in human immune system strongly depends on microflora-induced pro-and anti-inflammatory activities. Probiotics are important components of microflora.
- Trial name
- NCT00763399
- Testing
- probiotics (antibiophilus(Lactobacillus casei), bio-three)
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Parkinson's Disease
Effects of Probiotics on Peripheral Immunity in Parkinson's Disease
Parkinson's Disease (PD) is a common neurodegenerative disease, with no disease-modifying treatment available, therapy is therefore only symptomatic.
- Trial name
- NCT05173701
- Testing
- Probiotics
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- Franca Marino
Pompe Disease
Observational Study for Subjects With Pompe Disease Undergoing Immune Modulation Therapies
Hypothesis: the effectiveness of treatment of Pompe Disease with rhGAA enzyme replacement therapy (ERT) is limited at least in part because patients develop antibodies against the provided rhGAA enzyme.
- Trial name
- NCT01451879
- Testing
- Rituximab, Miglustat
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Florida