Clinical trials: Impact of Vaccination
Invasive Meningococcal Disease
Can we Reduce the Number of Vaccine Injections for Children?
This open label randomised controlled study will evaluate the induction of immunity following varying schedules of vaccination with glyco-conjugate Neisseria meningitidis serogroup C (MenC) vaccines in infancy.
- Trial name
- MALTA (NCT01129518)
- Testing
- Glyco-conjugate Neisseria meningitidis serogroup C (MenC) vaccine, Routine schedule immunisations except monovalent MenC vaccine
- Where
- United Kingdom
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis, Diphtheria
Evaluation of an Infant Immunization Encouragement Program in Nigeria
Previous studies have shown that a small incentive can have a large impact on health behaviors like vaccinating children. New Incentives, an international non-governmental organization (NGO), aims to boost demand for immunization…
- Conditions
- Tuberculosis, Diphtheria, Tetanus, Pertussis
- Trial name
- NCT03870061
- Testing
- All Babies Are Equal Initiative (conditional cash transfer program)
- Where
- 3 sites in Nigeria
- Volunteers
- 5,187 people, healthy volunteers welcome
- Sponsor
- GiveWell
BCG Infection, Reaction - Vaccine
A Study of the Interaction Between BCG And MenC Immunisation: BAM
The Bacille Calmette-Guérin (BCG) vaccine is the only vaccine licenced to prevent tuberculosis (TB). The stimulus it gives to the immune system allows it to respond more effectively to a subsequent infection with TB.
- Conditions
- BCG Infection, Reaction - Vaccine, Immune Response
- Trial name
- BAM (NCT02002156)
- Testing
- BCG, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®, NeisVac-C®, Pediacel®, Infanrix™, Prevenar-13®, Menitorix®, Priorix®, Rotarix®
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Plasmodium Falciparum Malaria
Mass Vaccine and Drug Administration, Bangladesh
This is an open i.e. not blinded, cluster-randomised, controlled intervention study. The study will use a factorial design to estimate the protective effectiveness of mass drug administrations, mass vaccinations, combined mass…
- Trial name
- MVDA (NCT06068530)
- Testing
- DHA/piperaquine and a SLD-PQ, Study vaccine R21/Matrix-M™
- Where
- 2 sites in Bangladesh
- Volunteers
- 10,000 people
- Sponsor
- University of Oxford
Gastroenteritis
Impact of Rotavirus Vaccination on Hospital Pressures at a Large Paediatric Hospital in the UK: an Ecological Study
The impact of rotavirus vaccination on the burden of disease has been well documented. However, the anticipated reduction in hospital pressures has yet to be described.
- Trial name
- NCT03271593
- Testing
- No intervention
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
SARS CoV 2 Vaccination
Impact of COVID-19 Vaccination on Balance Function Among Adolescents: A Long-Term Perspective
Long term impact of COVID 19 vaccination on dizziness-related disability and balance in adolescence
- Trial name
- NCT06503926
- Testing
- SARS-COV-2 vaccination
- Where
- Egypt
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Sinai University
Incentives
Evaluating the Impact of Demand-Side Incentives (DSI) on Zero Dose Burden and Immunisation Coverage in Nigeria
The goal of this cluster Randomised Controlled Trial (cRCT) is to evaluate the impact and effectiveness of demand-side incentives (DSIs) in improving immunisation coverage and reducing the burden of zero-dose children between the…
- Trial name
- NCT06676787
- Testing
- Transportation Voucher, Comunity engagement and microplannnig support, Direct Facility Funding, Community Engagement, and Microplaning Support, Transportation Voucher, Direct Facility Funding, Community engagement and Microplanning support
- Where
- 2 sites in Nigeria
- Volunteers
- 115,589 people, healthy volunteers welcome
- Sponsor
- Corona Management Systems
Congenital Heart Defects, Thymectomy
Impact of Thymectomy on Immunity in Infants After Cardiac Surgery
Heart surgery in infants typically involves complete removal of the thymus gland to improve access to the heart. However, the thymus plays a key role in developing the immune system in early childhood, especially in the…
- Conditions
- Congenital Heart Defects, Thymectomy, Immunological Deficiency Syndrome
- Trial name
- THYMIC (NCT07019857)
- Testing
- Blood sample collection at surgery time and 12 months later
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
HIV
Measuring the Impact of Integrating Maternal and Newborn HIV Testing With Childhood Immunization Services
This randomized evaluation measured the impact of two levels of support for the integration of infant and postpartum maternal HIV testing with routine immunization services in Southern Zambia on the number of postpartum maternal…
- Trial name
- NCT02479659
- Testing
- HIV testing commodity reinforcement, Policy reinforcement meeting, Opt-out HIV testing for mothers and newborns
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IDinsight
Cancer , Healthy, HPV - Anogenital Human Papilloma Virus Infection
The Effect of the Health Belief Model-Based Education Given to Mothers of Children Aged 9-15 on HPV Knowledge Level and Child Vaccination
This study aims to examine the effects of education provided to mothers of children aged 9-15 within the framework of the Health Belief Model on mothers' knowledge, attitudes, and behaviors about Human Papillomavirus (HPV), and…
- Conditions
- Cancer , Healthy, HPV - Anogenital Human Papilloma Virus Infection, Health Belief Model
- Trial name
- NCT07450703
- Testing
- HEALTH BELİEF MODEL
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Gaziantep
Cholera
Introduction of Cholera Vaccine in Bangladesh
The purpose of this study is to conduct and evaluate the feasibility and effectiveness of a mass cholera vaccination program to reduce diarrhea due to Vibrio cholerae in a high incidence urban area.
- Trial name
- ICVB (NCT01339845)
- Testing
- ShanChol, Vaccine and behaviour
- Where
- Bangladesh
- Volunteers
- 240,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
COVID-19
COVID Booster in Pregnancy and Lactation
This is a prospective longitudinal cohort study to evaluate the impact of COVID-19 vaccination and booster on maternal and infant immunity against COVID-19 variants over time.
- Trial name
- NCT05543993
- Testing
- Bivalent COVID-19 Booster
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
DTP Vaccine Series Completion
Khushi Baby (KB): Novel Mobile Health Solution for Vaccination Record Keeping in India
This is a three arm cluster randomized controlled trial where the unit of randomization is the immunization camp. Immunization camps are the sole provider of vaccinations in our study area and have catchment areas of several…
- Trial name
- NCT02518178
- Testing
- NFC Necklace, Voice Reminder, NFC Sticker
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Khushi Baby Inc.
Newborn Morbidity
Impact of Explanation Given to Parents on Rate of Post-partum Influenza Vaccination
The aim of this study is to determine whether an explanation to parents for the need for post-partum influenza vaccination will influence their compliance.
- Trial name
- NCT03053674
- Testing
- Oral and written explanation, Follow-up questionnaire
- Where
- Israel
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
RSV Infection
Evaluation of the Effectiveness and Impact of Nirsevimab Administered as Routine Immunization
A longitudinal observational study based on routinely collected data on hospital and health care use for RSV infections will be undertaken.
- Trial name
- NIRSE-GAL (NCT06180993)
- Testing
- Nirsevimab
- Where
- Spain
- Volunteers
- 42,000 people
- Sponsor
- Federico Martinón Torres
Food Hypersensitivity
Impact of Vaccination on Th2 Immunity in Infancy
The purpose of this study is to assess the responses in the immune system of infants after they receive the vaccine against diphtheria, tetanus, and pertussis (DTaP).
- Trial name
- NCT02213341
- Testing
- Skin prick allergen test, Blood draw
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Vaccination Reaction
Early Antibiotic Therapy and Vaccination
Neonatal Sepsis is one of the most common causes of death in preterm infants. Therefore, up to 80% of very low birth weight infants receive antibiotic therapy in their first week of life.
- Trial name
- NCT04109833
- Testing
- ABT
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Rotavirus Gastroenteritis
Impact of Systematic Infants Vaccination Against Rotavirus on Gastroenteritis Hospitalization: a Prospective Study in Brest District, France.
Universal rotavirus vaccination program for infants born in Brest after February 2007, applied by the Centers for Maternal and Infant Health Protection, pediatricians and general practitioners.
- Trial name
- IVANHOE (NCT00740935)
- Testing
- Rotateq vaccine
- Where
- France
- Volunteers
- 7,204 people
- Sponsor
- University Hospital, Brest
Vaccination Hesitancy
Impact on Patients' Vaccine Hesitancy of a Motivational Interviewing Training in Initial Medical Training Course
In France, vaccination coverage of adolescents remains suboptimal, partly because of a loss of confidence, favoring the re-emergence of epidemics.
- Trial name
- MOTI-VAC_IMG (NCT05565755)
- Testing
- Motivational interview
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
HPV Infection, Cervical Disease
Impact of HPV Vaccination on HPV Infection and Cervical Related Disease Burden in Real-World Settings (HPV-RWS)
Take AS04 adjuvanted HPV16/18 vaccine as an example to evaluate the impact of HPV vaccination on HPV infection and related disease burden in the real world based on prospective cohort and Yinzhou Regional Health Information…
- Trial name
- HPV-RWS (NCT05341284)
- Testing
- Questionnaire Survey and Cervical Cancer Screening
- Volunteers
- healthy volunteers welcome
- Sponsor
- Peking University