Clinical trials: Impaired Renal Function
Acute Kidney Injury
Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in infants is common and associated with poor outcomes. Peritoneal dialysis (PD) and furosemide have been used to attain negative fluid balance due to AKI induced…
- Trial name
- NCT01709227
- Testing
- Furosemide, Peritoneal Dialysis
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Stem Cell Transplant Complications, Acute Graft Versus Host Disease
Study on the Serum Metabolic Markers and Early Complications After Allo-HSCT： Cohort Study
This study aims to establish a cohort of 500 patients with hematological disease who undergoing allogeneic hematopoietic stem cell transplantation in the northwest region.
- Conditions
- Stem Cell Transplant Complications, Acute Graft Versus Host Disease, Acute Kidney Injury, Major Adverse Cardiac Events
- Trial name
- NCT06386445
- Testing
- Serum metabolomics sequencing
- Volunteers
- 500 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Kidney Injury, Drug Use
A Big Data Approach to Predict NEOnatal Acute Kidney Injury in Newborns expoSed to nephroTOxic Drugs (NeoAKI STOP)
This observational retrospective study aims to learn about the incidence of acute kidney (AKI) injury in newborns in infants exposed to nephrotoxic drugs with a big data approach.
- Conditions
- Acute Kidney Injury, Drug Use, Drug Interaction, Drug Toxicity
- Trial name
- NeoAKISTOP (NCT05851222)
- Where
- Italy
- Volunteers
- 4,200 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Renal Insufficiency, Chronic
Explore New Magnetic Resonance Technology in Assessment of Renal Dysfunction
Currently, renal biopsy is the gold standard for evaluating renal pathology and renal fibrosis, but it is invasive and carries the risk of serious complications; and the sampled tissue is only a small part of the kidney, which is…
- Trial name
- NCT06366529
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Zhen Li
Covid19, Kidney Transplant Infection
Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience From the Middle East
Methods: Out of 2000 kidney transplant recipients in our center in Kuwait, collecting data was started for all COVID-19-positive kidney transplant recipients till August 2020.
- Conditions
- Covid19, Kidney Transplant Infection, Risk Factor, Cardiovascular, Immunosuppression
- Trial name
- OMC-KTR (NCT04542954)
- Testing
- Optimized Management of Covid-19 Positive Kidney Transplant Recipients: Single Center Experience from the Middle East
- Where
- Kuwait
- Volunteers
- 104 people
- Sponsor
- Hamid Al-Essa Organ Transplant Center
Cardio Vascular Disease, Diabetes (DM)
Holistic CRM Care vs Standard of Care in a Primary Care Setting
Cardiovascular disease, high blood pressure, chronic kidney disease, and type 2 diabetes, collectively referred to as Cardio-Renal-Metabolic (CRM) conditions, are among the most common chronic diseases in society.
- Conditions
- Cardio Vascular Disease, Diabetes (DM), Chronic Kidney Disease
- Trial name
- HOPE-CRM (NCT07819383)
- Testing
- CRM care
- Volunteers
- 6,000 people
- Sponsor
- Danderyd Hospital
Chronic Kidney Disease Requiring Hemodialysis
The Effect of Peer Support on Disease Adaptation and Self-Care Ability in Individuals Diagnosed With Chronic Kidney Failure
This study was designed as an interventional, pretest-posttest controlled trial to examine the effects of peer interaction on disease adaptation and self-care ability in patients newly diagnosed with chronic kidney failure and…
- Trial name
- Peer support (NCT07125976)
- Testing
- peer support
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- pınar dogan
End-stage Kidney Disease, End-stage Renal Disease
The Prevalence of Sarcopenia in a Cohort of Haemodialysis Patients and Its Correlation With Mortality
The study aims to explore the correlation between the prevalence of sarcopenia and one year mortality amongst patients on maintenance hemodialysis
- Conditions
- End-stage Kidney Disease, End-stage Renal Disease, Dialysis Dependent Chronic Kidney Disease, Sarcopenia
- Trial name
- NCT06477978
- Testing
- Hand grip function testing
- Where
- Egypt
- Volunteers
- 274 people
- Sponsor
- Kasr El Aini Hospital
Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism (SHPT)
A Study to Evaluate Safety, Efficacy and Pharmacokinetics of Paricalcitol For Treatment of Secondary Hyperparathyroidism (SHPT) in Pediatric Participants With Stage 5 Chronic Kidney Disease (CKD)
The main objective of this study is to evaluate the safety, efficacy and pharmacokinetics of paricalcitol oral solution in pediatric participants of ages 0 to 9 years with SHPT associated with stage 5 CKD receiving Peritoneal…
- Trial name
- NCT04064827
- Testing
- Paricalcitol
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 2 people
- Sponsor
- AbbVie
Secondary Hyperparathyroidism
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis
Assess the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of etelcalcetide in the treatment of secondary hyperparathyroidism (SHPT) in pediatric participants between ≥ 2 to < 18 years of age, with chronic…
- Trial name
- NCT03969329
- Testing
- Etelcalcetide
- Where
- 23 sites in Belgium, Czechia and 10 more
- Volunteers
- 24 people
- Sponsor
- Amgen
Cardiovascular Disease, Renal Insufficiency, Acute
Acetylcysteine Against Acute Renal Insult During Cardiopulmonary Bypass.
The purpose of this study is to determine whether N-acetylcysteine is effective in the prophylaxis of post-cardiopulmonary bypass acute renal impairment.
- Conditions
- Cardiovascular Disease, Renal Insufficiency, Acute, Cardiopulmonary Bypass
- Trial name
- NCT00190034
- Testing
- N-Acetylcysteine 600mg/tab
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Congenital Heart Disease, Surgery--Complications
A Predictive Score System for AKI Following Pediatric Cardiac Surgery
Acute kidney injury (AKI) has been recognized as a typical post- operative complication among the children undergoing surgical repair of a congenital cardiac defect.
- Conditions
- Congenital Heart Disease, Surgery--Complications, Acute Kidney Injury
- Trial name
- NCT05489263
- Testing
- No intervention
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Scoliosis, Acute Kidney Injury
Effects of Goal-directed Fluid Therapy on Post-operative Outcomes in Children Undergoing Scoliosis Repair
Surgery for scoliosis correction, the abnormal curvature of the spine, is a major procedure often undertaken in adolescents. In adult anesthesia, there is a large volume of literature debating how to optimize fluids administered…
- Trial name
- CardioQ-RP (NCT02463175)
- Testing
- Plasmalyte, Goal-directed fluid therapy (GDT)
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- University of British Columbia
Brain Injuries, Malaria
An MRI Ancillary Study of a Malaria Fever Investigation
This study will seek consent from parents of children enrolled in the Malaria FEVER study to obtain neuroimaging and 12-month neuropsychiatric outcomes data and kidney function on their child.
- Conditions
- Brain Injuries, Malaria, MRI Imaging, Neurocognitive Deficits
- Trial name
- MRIA (NCT05746819)
- Testing
- Aggressive antipyretics therapy of fever vs usual care in the Malaria RCT study
- Where
- 2 sites in Malawi, Zambia
- Volunteers
- 181 people
- Sponsor
- University of Rochester
Chronic Kidney Disease
Improving Care for Patients With Chronic Kidney Disease Using EMRALD
This pragmatic cluster randomized controlled trial will test the impact of feedback and a toolkit aimed at improving the management of chronic kidney disease (CKD) in the primary care setting.
- Trial name
- NCT02274298
- Testing
- CKD feedback and tools
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Chronic Kidney Diseases
Validation, Implementation, and Cost-analysis of a Strategy for Personalized Diagnosis of Rare Kidney Diseases
Chronic kidney disease (CKD) affects about 10% of the world population, with high morbidity and mortality. Genetic kidney diseases are increasingly recognized across all age groups and represent over 20% of all the causes of CKD.
- Trial name
- NCT06324136
- Testing
- Implementation of the diagnostic algorithm
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Meyer Children's Hospital IRCCS
Kidney Transplantation in Highly Sensitized Patients
Imlifidase Prior to Kidney Transplant in Highly Sensitised Children
The goal of this clinical trial is to learn about the efficacy and safety of imlifidase in highly sensitized paediatric patients, 1-17 years old, with end stage renal disease (ESRD).
- Trial name
- DINKY (NCT05753930)
- Testing
- Imlifidase
- Where
- 6 sites in Finland, France and 3 more
- Volunteers
- 10 people
- Sponsor
- Hansa Biopharma AB
Chronic Kidney Diseases
Effects of Resistant Starch Diet on the Gut Microbiome in Chronic Kidney Disease
The investigators want to learn more about how to help people who have chronic kidney disease (CKD). This study will increase the investigators understanding of how diet affects factors that can slow the progression of kidney…
- Trial name
- NCT03356990
- Testing
- Resistant Starch
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Arkansas
Acute Kidney Injury
Acute Kidney Injury in Pediatric Polytrauma Patients at Assiut University Trauma Unit: A Cross-Sectional Study on Incidence and Predictive Risk Factors
This study aims to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized pediatric patients and identify the risk, and severity of AKI.
- Trial name
- NCT06177886
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Chronic Kidney Disease
Long Term Impact of Pediatric Acute Renal Injury in Severe Sepsis
Sepsis is the most common cause of childhood death worldwide. Millions of children survive, but are left with impaired health. Sepsis-related Acute Kidney Injury (sAKI) is increasingly recognized as a significant factor…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease, Hypertension
- Trial name
- IMPRESS (NCT02372721)
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida