Clinical trials: Implementation
HIV Infections, Pregnancy Related
PrEP Implementation for Mothers in Antenatal Care
In a region with 15-20% HIV prevalence, an estimated 20% of HIV-uninfected women could have HIV exposures in pregnancy. In a theoretical scenario of perfect PrEP coverage, all women at risk receive PrEP while no women not at HIV…
- Trial name
- PrIMA (NCT03070600)
- Testing
- Universal PrEP Counseling, Targeted PrEP Counseling
- Where
- 20 sites in Kenya
- Volunteers
- 4,447 people
- Sponsor
- University of Washington
Suicide
Adaptive Implementation Intervention for VA Suicide Risk Identification Strategy
The overall objective of this national quality improvement project is to develop an adaptive implementation strategy to improve the implementation of suicide risk screening and evaluation in Veterans Health Administration…
- Trial name
- NCT04243330
- Testing
- Audit and Feedback, External Facilitation
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pediatric Abusive Head Trauma
The CDR Implementation Trial
To increase the accuracy of doctors' decisions to launch or forgo child abuse evaluations in their young, acutely head-injured patients, investigators have derived and validated a clinical decision rule (CDR) that detects abusive…
- Trial name
- NCT03162354
- Testing
- Application of a validated Clinical Decision Rule (CDR) as an AHT screening tool
- Where
- 8 sites in United States
- Volunteers
- 420 people
- Sponsor
- Milton S. Hershey Medical Center
Prostate Cancer
DeADT - Living Well With Prostate Cancer
The goal of this randomized de-implementation trial is to compare two strategies to reduce low-value androgen deprivation therapy (ADT) use for prostate cancer care.
- Trial name
- DeADT-LW (NCT06199986)
- Testing
- ADT Order Check Attestation (Or), Provider Script (Sc)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Childhood
Dissemination and Implementation of Improving Pediatric Obesity Practice Using Prompts
The purpose of this study is to evaluate the dissemination and implementation of electronic health record-based clinical decision support tools for the management of pediatric overweight and obesity in primary care.
- Trial name
- iPOP-UP (NCT05627011)
- Testing
- Improving Pediatric Obesity Practice Using Prompts (iPOP-UP)
- Where
- 3 sites in United States
- Volunteers
- 58,364 people
- Sponsor
- Yale University
Substance Abuse
Preventing Substance Use Among Youth
Using a 2-group, mixed method group randomized trial design, this pilot study will compare standard implementation versus Enhanced Replicating Effective Programs (Enhanced REP) to deliver Michigan Model for Health (MMH) in…
- Trial name
- NCT04752189
- Testing
- Enhanced Replicating Effective Programs (Enhanced REP), Standard implementation
- Where
- United States
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Depression, Anxiety
Improving Student Mental Health: Adaptive School-based Implementation of CBT
The overarching goal of this study is to improve the delivery of an established, evidence-based intervention (cognitive-behavioral therapy-CBT) in Michigan schools through different implementation strategies designed to better…
- Trial name
- NCT03541317
- Testing
- Stage 1 Strategy: REP, Stage 1 Strategy: REP + Coaching, Stage 2 Strategy: Augment with Facilitation
- Where
- United States
- Volunteers
- 1,329 people
- Sponsor
- University of Michigan
Fall Related Injury, Social Isolation
KOSO (Keep On Stepping On)/ Stepping Online
The overall purpose of this multi-phase study is to develop (Phase 1) and test potential effectiveness and feasibility of Keep On Stepping On (KOSO)/Stepping Online, an online falls prevention maintenance program for Stepping On…
- Trial name
- NCT02774889
- Testing
- Stepping Online
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Terminal Conditions, End of Life
Evaluation of Methods for Implementation of a Comfort Care Order Set
The overarching goal of this research program is to improve the quality of end-of-life care provided to Veterans dying in VA Medical Centers (VAMCs), by transferring the best practices of home hospice and palliative care for the…
- Trial name
- BEACON II (NCT02383173)
- Testing
- Basic Implementation Approach, Enhanced Implementation Approach
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pre-exposure Prophylaxis, HIV Infections
Le Kip Kip: A Campaign to Change Social Norms and Build Sustainable Demand for PrEP Among Women in South Africa
The purpose of this study is to evaluate the impact of a social media campaign and community engagement activities to promote pre-exposure prophylaxis (PrEP) use among young women and to influence community norms around PrEP in…
- Trial name
- NCT05417620
- Testing
- Social Media Campaign, PrEP Champions, Community Mobilization
- Where
- South Africa
- Volunteers
- 601 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Autism Spectrum Disorder, Implementation Science
Refining and Implementing Technology-Enhanced Family Navigation to Promote Early Access and Engagement With Mental Health Services for Youth With Autism
This project, Refining and Implementing Technology-Enhanced Family Navigation to Promote Early Access and Engagement with Mental Health Services for Youth with Autism (ATTAIN NAV) is focused on adapting and implementing family…
- Conditions
- Autism Spectrum Disorder, Implementation Science, Mental Health, Behavioral Health
- Trial name
- ATTAIN NAV (NCT05344378)
- Testing
- ATTAIN NAV Technology-Enhanced Family Navigation Model
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Hepatitis C
eHealth Partnered Evaluation Initiative - Evaluation of the Initial Deployment of VA's Annie Texting System
Conduct a rigorous formative evaluation of the initial deployment of the Annie texting system across several pilot test sites and from these findings, develop and test an augmented implementation strategy to facilitate more rapid…
- Trial name
- AnnieEval (NCT03898349)
- Testing
- Annie text messaging system, Annie text messaging system with Usual implementation, Annie text messaging system with Augmented implementation
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- VA Office of Research and Development
Surgical Site Infection
De-Implementation of Unnecessary Surgical Antibiotic Prophylaxis in Children
The overall objective of this study is to identify the best strategy to eliminate unnecessary antibiotic use after surgery in pediatric surgical procedures considered low-risk for an SSI.
- Trial name
- OPerAtiC (NCT04366440)
- Testing
- Order set review and modification with facilitation, Order set review and modification
- Where
- 10 sites in United States
- Volunteers
- 18,267 people
- Sponsor
- Washington University School of Medicine
Knee Osteoarthritis
Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0
Implementing Group Physical Therapy (PT) for Veterans with Knee Osteoarthritis (OA): Function QUERI 2.0 (Group PT) aims to implement, evaluate and sustain Group PT in 16 VA sites using a type III effectiveness-implementation…
- Trial name
- Group PT (NCT05282927)
- Testing
- Implementation Strategy: Foundational REP, Implementation Strategy: Enhanced REP (enREP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Asthma
Reducing Asthma Morbidity In High Risk Minority Preschool Children
Low-income, minority children are disproportionately affected by asthma and can experience higher rates of asthma attacks, lower lung function, decreased physical activity, increases in school absenteeism, and higher rates of…
- Trial name
- ABC-HS (NCT01519453)
- Testing
- Home Based Asthma Education
- Where
- United States
- Volunteers
- 404 people
- Sponsor
- Johns Hopkins University
Premature Birth
Group Antenatal Care: Effectiveness and Contextual Factors Linked to Implementation Success in Malawi
In this study, we test the effectiveness of an evidence-based model of group antenatal care by comparing it to individual (usual) antenatal care (Aim 1) across 7 antenatal clinics in Blantyre District, Malawi.
- Trial name
- NCT03673709
- Testing
- Antenatal Care
- Where
- 7 sites in Malawi
- Volunteers
- 1,887 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Prostate Cancer
A Multi-modal, Physician-centered Intervention to Improve Guideline-concordant Prostate Cancer Imaging
The primary aim of this study is to determine whether a multi-modal, physician-focused behavioral intervention can improve facility-level guideline-concordant utilization of prostate cancer staging imaging.
- Trial name
- NCT03445559
- Testing
- Clinical Order Check, Academic Detailing, Audit and Feedback
- Where
- 11 sites in United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Attention Deficit Hyperactivity Disorder Symptoms
Implementation Strategy Resource Package for Behavioral Classroom Interventions: Pilot Test
The purpose of this study is to pilot test for feasibility and initial promise an implementation strategy resource package that aims to support teachers in using behavioral classroom management interventions for children with…
- Trial name
- NCT05489081
- Testing
- Positive Behavior Management Toolkit
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Suicide, Engagement, Patient
The BH-Works Suicide Prevention Program for Sexual and Gender Minority Youth
Youth suicide is a serious public health concern. Compared to their heterosexual and cisgender peers, sexual and gender minority (SGM) adolescents report higher rates of suicidal ideation and suicide attempts.
- Trial name
- NCT05922670
- Testing
- The Behavioral Health-Works Suicide Prevention Program for Sexual and Gender Minority Youth
- Where
- 4 sites in United States
- Volunteers
- 18 people
- Sponsor
- Virginia Polytechnic Institute and State University
Sickle Cell Trait
Increasing Documentation and Disclosure of Sickle Cell Trait Status: An Implementation Science Approach
The hemoglobinopathy newborn screen (NBS) performed on all neonates in the U.S. allows for early life-saving medical care for infants with sickle cell disease (SCD), an autosomal recessive genetic disorder.
- Trial name
- NCT05387564
- Testing
- SCT Documentation and Disclosure Toolkit (SCT-DD)
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Nemours Children's Clinic