Clinical trials: Implementation Strategies, open to volunteers
Chronic Kidney Diseases
Validation, Implementation, and Cost-analysis of a Strategy for Personalized Diagnosis of Rare Kidney Diseases
Chronic kidney disease (CKD) affects about 10% of the world population, with high morbidity and mortality. Genetic kidney diseases are increasingly recognized across all age groups and represent over 20% of all the causes of CKD.
- Trial name
- NCT06324136
- Testing
- Implementation of the diagnostic algorithm
- Where
- 3 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Meyer Children's Hospital IRCCS
Severe Malaria, Severe Anaemia
Post-discharge Malaria Chemoprevention Implementation Trial in Benin
The proposed research aims to conduct implementation trials in Benin, co-designed with national stakeholders, to evaluate different delivery strategies for optimizing health system delivery of post-discharge malaria…
- Trial name
- PDMC-SL (NCT06601712)
- Testing
- Adherence support strategy A, Adherence support strategy B, Control
- Where
- 2 sites in Benin
- Volunteers
- 648 people
- Sponsor
- Institut de Recherche Clinique du Benin
HIV Infections, Syphilis Infection
Implementation of an Opt-Out Testing and Rapid Diagnostic Strategy for Syphilis and HIV in Pregnant Patients Presenting to the Emergency Department
The purpose of this study is to evaluate infection detection and treatment initiation rates for syphilis and HIV before and after integration of the Chembio DPP® HIV-Syphilis rapid POC test into an ongoing Emergency Department…
- Trial name
- NCT07525076
- Testing
- Chembio HIV/Syphilis rapid Point of Care (POC) test, Laboratory-based HIV and syphilis testing
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Early-onset Sepsis
Promoting Optimal Treatment Choices in Neonates With Suspected Early-Onset Sepsis
In this study, three neonatal evidence-based antibiotic stewardship strategies will be implemented in Dutch hospitals. These include the early-onset sepsis (EOS) calculator, procalcitonin (PCT)-guided therapy, and IV-to-oral…
- Trial name
- PrOTeCt-NEO (NCT06845332)
- Where
- 11 sites in Netherlands
- Volunteers
- 55,000 people
- Sponsor
- Franciscus Gasthuis
Sustainability
Sustainability and Precision Prevention Project
This is a five-year hybrid type 3 effectiveness-implementation study evaluating multilevel strategies to sustain a nationwide implementation of an evidence-based HIV prevention curriculum in schools.
- Trial name
- NCT07153042
- Testing
- Biweekly monitoring and feedback (BMF), Site-based assistance and mentorship (SAM), Enhanced site-based assistance and mentorship (Enhanced SAM)
- Where
- The Bahamas
- Volunteers
- 3,705 people
- Sponsor
- University of Massachusetts, Worcester
Depression
Latino Teen Depression Treatment Study
Despite experiencing higher rates of depressive symptoms (Center for Disease Control and Prevention, 2020) and similar rates of Major Depressive Disorder (MDD; Substance Abuse and Mental Health Services Administration (SAMHSA)…
- Trial name
- NCT05499182
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
Human Papillomavirus Infection
Investigating Facilitator-driven, Multi-level Implementation Strategies in Federally Qualified Health Centers to Improve Provider Recommendation and HPV Vaccination Rates Among Latino/a Adolescents
The purpose of this study is to determine the provider- and practice-level characteristics that influence the impact of implementation strategies guided by practice facilitation in each clinical practice, to test whether the…
- Trial name
- NCT06598475
- Testing
- Facilitator-driven provider- and practice-level implementation strategies for influencing provider recommendations and practice-level HPV vaccination rates
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- The University of Texas Health Science Center, Houston
Asthma in Children
SMART Implementation-Effectiveness Trial 2
While single maintenance and reliever therapy (SMART) has been the preferred management strategy for Step 3 and 4 (moderate/severe) asthma management since the 2020 NIH asthma guideline updates, adoption of SMART has not been…
- Trial name
- SMART SIMPLE (NCT07138027)
- Testing
- Clinical decision support + education (CDS+) and population health management (PHM), Control
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Attention Deficit Hyperactivity Disorder Symptoms
Implementation Strategies for Caregiver and Teacher Use of Behavioral Interventions: Aim 2
The purpose of this study is to pilot test for feasibility and initial promise an implementation strategy resource package that aims to support caregivers in using behavioral interventions for children with hyperactive…
- Trial name
- NCT07321327
- Testing
- Positive Behavior Management Toolkit for Caregivers, Positive Behavioral Management Toolkit for Teachers
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Pregnancy Related, Hypertension
Testing Implementation Strategies to Support Clinic Fidelity to an Outpatient Hypertension Bundle
The goal of this clinical trial is to test an approach to improve care for pregnant and post-partum patients with high blood pressure.
- Trial name
- ACHIEVE (NCT06002165)
- Testing
- Usual Care, ACHIEVE Multi-component Implementation Strategy
- Where
- 8 sites in United States
- Volunteers
- 5,677 people
- Sponsor
- University of North Carolina, Chapel Hill
Substance Related Disorders
Testing Implementation Strategies to Scale-up a Multicomponent Continuum of Service Intervention for Families Involved in Systems With Parental Opioid and Methamphetamine Use
This study will explore how to expand the Just Care for Families (JCFF) program beyond its current sites in Oregon, while addressing two main challenges: the developer team cannot provide ongoing support to every new program, and…
- Trial name
- NCT07365293
- Testing
- Just Care for Families (JCFF), Just Care for Families (JCFF) App, Just Care for Families (JCFF) App Feedback
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Chestnut Health Systems
Systemic Lupus Erthematosus (SLE)
Team-based Implementation of Hypertension Management in Childhood Lupus
The goal of this study is to compare the effectiveness of widely used implementation strategies to promote adherence to guideline-concordant evidence-based practices for monitoring and controlling blood pressure in patients with…
- Trial name
- ABOUT TIME (NCT07792733)
- Testing
- Health Navigator Engagement, Team Charter with Performance Monitoring, Pre-visit worksheet
- Volunteers
- 1,200 people
- Sponsor
- Boston Children's Hospital
Goal-Setting
Feasibility of an Implementation Strategy for a Physical Activity Program in Rural Middle Schools
The investigators aim to build on the pilot study data looking at the feasibility of implementation of Goal Setting alongside Hoosier Sport at two schools (Eastern Greene Middle School and White River Valley Middle School).
- Trial name
- NCT07859033
- Testing
- Goal-Setting in Sport-Based Youth Development, No Goal-Setting Program
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dietary Behaviors, Fruit Consumption
A Comparative Intervention Study on Strategies for Fruit Distribution and Awareness Campaigns in Schools
This implementation study evaluates two strategies to increase fruit consumption among Swedish students. (1) installing fruit stands in schools and (2) combining fruit stands with a health-awareness campaign.
- Conditions
- Dietary Behaviors, Fruit Consumption, Dietary Habits, Healthy Eating
- Trial name
- NCT07385820
- Testing
- Fruit Stand Availability, Awareness Campaign
- Where
- 2 sites in Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Implementation Science, Type 1 Diabetes in Adolescence
Pilot Implementation Trial of Implementation Toolkits for Diabetes Coaching
The goal of this study is to learn if toolkits of implementation strategies (e.g., provider and staff education, clear plan for how to refer and bill) help pediatric type 1 diabetes medical and psychology providers deliver a…
- Conditions
- Implementation Science, Type 1 Diabetes in Adolescence, Implementation Strategies
- Trial name
- NCT07766811
- Testing
- Base Implementation Toolkit (BIT), BIT-Enhanced, BIT-Sustainment
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Point of Care STI Testing
Point of Care STI Testing
The proposed research hypothesizes that point-of-care testing (POCT) for sexually transmitted infections (STIs) gonorrhea and chlamydia will be a feasible, acceptable, and appropriate implementation strategy for improving HIV…
- Trial name
- NCT06844045
- Testing
- Gonorrhea/chlamydia Point-of-Care Testing
- Where
- United States
- Volunteers
- 6,460 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Anxiety Disorders, Depressive Symptoms
Collaborative Redesign of Implementation Strategies for the Brief Intervention for School Clinicians
Schools are the most common venue for youth mental health services, but school mental health (SMH) typically does not use evidence-based clinical interventions (CI), common elements of effective mental health, or effective…
- Conditions
- Anxiety Disorders, Depressive Symptoms, Mental Health Issue
- Trial name
- BRISC (NCT06968949)
- Testing
- Unadapted Brief Intervention for School Clinicians (BRISC; BR-O), Brief Intervention for School Clinicians (BRISC) with Implementation Strategies Adapted for School-Employed Practitioners (BR-A)
- Volunteers
- 60 people
- Sponsor
- University of Washington
Adolescent HIV Infection, Transition to Adult Care
Scale-up of an Evidence-based Adolescent Transition Package to Support Transitional Care Among Youth Living With HIV
Ending the HIV epidemic for youth living with HIV will require implementation and optimization of evidence-based interventions that address barriers to treatment.
- Conditions
- Adolescent HIV Infection, Transition to Adult Care, Implementation Science, Implementation Strategies
- Trial name
- ATTACH-Scale (NCT06924073)
- Testing
- ATP-Youth Enhanced Strategy (ATP-YES)
- Where
- 25 sites in Kenya
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- University of Washington
Acceptability, Feasibility Studies
Digital Support Strategies for Caregiver Home Practice
This project is a pilot trial of the Engaging Families home practice smartphone application (or "app") as an add on to a family-based prevention program.
- Trial name
- NCT06907966
- Testing
- Engaging Families home practice app, Scheduling app
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Physical Activity, Sedentary Behavior
B4B Evolution Type II Hybrid Effectiveness-Implementation Trial
Break4Brain Evolution is a school-based programme designed to help teachers incorporate brief, safe and inclusive movement activities into normal classroom routines.
- Conditions
- Physical Activity, Sedentary Behavior, Cognition, Academic Acheivement
- Trial name
- B4B Evolution (NCT07726732)
- Testing
- Break4Brain Evolution
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of the Balearic Islands